Cryogels from poly(2-hydroxyethyl methacrylate): macroporous, interconnected materials with potential as cell scaffolds
(2007) In Soft Matter 3(9). p.1176-1184- Abstract
- Macroporous hydrogels (MHs) have been prepared by cross-linking polymerization of hydroxyethyl methacrylate (HEMA) or cross-linking co-polymerization of HEMA with dimethylacrylamide (DMAA) in semi-frozen state. The MHs are elastic and have a unique structure of large interconnected pores with pore sizes up to 100 µm and total porosity of 94–97%, as demonstrated by micro-computed tomography. The stiffness of such MHs increased with total monomer concentration and with the ratio of DMAA in the composition. Pore-surface modification of the HEMA MHs was achieved by grafting a stimuli-responsive polymer, poly(N-isopropylacrylamide) (PNIPAM), with high density using atom transfer radical polymerization (ATRP). The effect of catalytic system,... (More)
- Macroporous hydrogels (MHs) have been prepared by cross-linking polymerization of hydroxyethyl methacrylate (HEMA) or cross-linking co-polymerization of HEMA with dimethylacrylamide (DMAA) in semi-frozen state. The MHs are elastic and have a unique structure of large interconnected pores with pore sizes up to 100 µm and total porosity of 94–97%, as demonstrated by micro-computed tomography. The stiffness of such MHs increased with total monomer concentration and with the ratio of DMAA in the composition. Pore-surface modification of the HEMA MHs was achieved by grafting a stimuli-responsive polymer, poly(N-isopropylacrylamide) (PNIPAM), with high density using atom transfer radical polymerization (ATRP). The effect of catalytic system, initiator content and the addition of sacrificial initiator on the ATRP process have been studied. The elasticity, possibility of drying and fast re-swelling, tunable mechanical properties and the macroporous, interconnected structure of HEMA MHs are of interest for biomedical applications such as cell culturing. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/792820
- author
- Savina, Irina LU ; Cnudde, V. ; D’Hollander, S. ; Van Hoorebeke, L. ; Mattiasson, Bo LU ; Galaev, Igor LU and Du Prez, F.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Soft Matter
- volume
- 3
- issue
- 9
- pages
- 1176 - 1184
- publisher
- Royal Society of Chemistry
- external identifiers
-
- wos:000248731700010
- scopus:34547860038
- ISSN
- 1744-6848
- DOI
- 10.1039/b706654f
- language
- English
- LU publication?
- yes
- id
- e345b434-e398-4398-bbaf-b5e47304bc5b (old id 792820)
- date added to LUP
- 2016-04-01 17:04:35
- date last changed
- 2022-01-29 00:11:56
@article{e345b434-e398-4398-bbaf-b5e47304bc5b, abstract = {{Macroporous hydrogels (MHs) have been prepared by cross-linking polymerization of hydroxyethyl methacrylate (HEMA) or cross-linking co-polymerization of HEMA with dimethylacrylamide (DMAA) in semi-frozen state. The MHs are elastic and have a unique structure of large interconnected pores with pore sizes up to 100 µm and total porosity of 94–97%, as demonstrated by micro-computed tomography. The stiffness of such MHs increased with total monomer concentration and with the ratio of DMAA in the composition. Pore-surface modification of the HEMA MHs was achieved by grafting a stimuli-responsive polymer, poly(N-isopropylacrylamide) (PNIPAM), with high density using atom transfer radical polymerization (ATRP). The effect of catalytic system, initiator content and the addition of sacrificial initiator on the ATRP process have been studied. The elasticity, possibility of drying and fast re-swelling, tunable mechanical properties and the macroporous, interconnected structure of HEMA MHs are of interest for biomedical applications such as cell culturing.}}, author = {{Savina, Irina and Cnudde, V. and D’Hollander, S. and Van Hoorebeke, L. and Mattiasson, Bo and Galaev, Igor and Du Prez, F.}}, issn = {{1744-6848}}, language = {{eng}}, number = {{9}}, pages = {{1176--1184}}, publisher = {{Royal Society of Chemistry}}, series = {{Soft Matter}}, title = {{Cryogels from poly(2-hydroxyethyl methacrylate): macroporous, interconnected materials with potential as cell scaffolds}}, url = {{http://dx.doi.org/10.1039/b706654f}}, doi = {{10.1039/b706654f}}, volume = {{3}}, year = {{2007}}, }