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Cryogels from poly(2-hydroxyethyl methacrylate): macroporous, interconnected materials with potential as cell scaffolds

Savina, Irina LU ; Cnudde, V.; D’Hollander, S.; Van Hoorebeke, L.; Mattiasson, Bo LU ; Galaev, Igor LU and Du Prez, F. (2007) In Soft Matter 3(9). p.1176-1184
Abstract
Macroporous hydrogels (MHs) have been prepared by cross-linking polymerization of hydroxyethyl methacrylate (HEMA) or cross-linking co-polymerization of HEMA with dimethylacrylamide (DMAA) in semi-frozen state. The MHs are elastic and have a unique structure of large interconnected pores with pore sizes up to 100 µm and total porosity of 94–97%, as demonstrated by micro-computed tomography. The stiffness of such MHs increased with total monomer concentration and with the ratio of DMAA in the composition. Pore-surface modification of the HEMA MHs was achieved by grafting a stimuli-responsive polymer, poly(N-isopropylacrylamide) (PNIPAM), with high density using atom transfer radical polymerization (ATRP). The effect of catalytic system,... (More)
Macroporous hydrogels (MHs) have been prepared by cross-linking polymerization of hydroxyethyl methacrylate (HEMA) or cross-linking co-polymerization of HEMA with dimethylacrylamide (DMAA) in semi-frozen state. The MHs are elastic and have a unique structure of large interconnected pores with pore sizes up to 100 µm and total porosity of 94–97%, as demonstrated by micro-computed tomography. The stiffness of such MHs increased with total monomer concentration and with the ratio of DMAA in the composition. Pore-surface modification of the HEMA MHs was achieved by grafting a stimuli-responsive polymer, poly(N-isopropylacrylamide) (PNIPAM), with high density using atom transfer radical polymerization (ATRP). The effect of catalytic system, initiator content and the addition of sacrificial initiator on the ATRP process have been studied. The elasticity, possibility of drying and fast re-swelling, tunable mechanical properties and the macroporous, interconnected structure of HEMA MHs are of interest for biomedical applications such as cell culturing. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Soft Matter
volume
3
issue
9
pages
1176 - 1184
publisher
Royal Society of Chemistry
external identifiers
  • wos:000248731700010
  • scopus:34547860038
ISSN
1744-6848
DOI
10.1039/b706654f
language
English
LU publication?
yes
id
e345b434-e398-4398-bbaf-b5e47304bc5b (old id 792820)
date added to LUP
2008-01-08 16:26:43
date last changed
2017-10-01 04:52:29
@article{e345b434-e398-4398-bbaf-b5e47304bc5b,
  abstract     = {Macroporous hydrogels (MHs) have been prepared by cross-linking polymerization of hydroxyethyl methacrylate (HEMA) or cross-linking co-polymerization of HEMA with dimethylacrylamide (DMAA) in semi-frozen state. The MHs are elastic and have a unique structure of large interconnected pores with pore sizes up to 100 µm and total porosity of 94–97%, as demonstrated by micro-computed tomography. The stiffness of such MHs increased with total monomer concentration and with the ratio of DMAA in the composition. Pore-surface modification of the HEMA MHs was achieved by grafting a stimuli-responsive polymer, poly(N-isopropylacrylamide) (PNIPAM), with high density using atom transfer radical polymerization (ATRP). The effect of catalytic system, initiator content and the addition of sacrificial initiator on the ATRP process have been studied. The elasticity, possibility of drying and fast re-swelling, tunable mechanical properties and the macroporous, interconnected structure of HEMA MHs are of interest for biomedical applications such as cell culturing.},
  author       = {Savina, Irina and Cnudde, V. and D’Hollander, S. and Van Hoorebeke, L. and Mattiasson, Bo and Galaev, Igor and Du Prez, F.},
  issn         = {1744-6848},
  language     = {eng},
  number       = {9},
  pages        = {1176--1184},
  publisher    = {Royal Society of Chemistry},
  series       = {Soft Matter},
  title        = {Cryogels from poly(2-hydroxyethyl methacrylate): macroporous, interconnected materials with potential as cell scaffolds},
  url          = {http://dx.doi.org/10.1039/b706654f},
  volume       = {3},
  year         = {2007},
}