Dendritic cell subsets in the intestinal lamina propria: Ontogeny and function.
(2013) In European Journal of Immunology 43(12). p.3098-3107- Abstract
- The intestinal mucosa is exposed to large amounts of foreign antigen (Ag) derived from commensal bacteria, dietary Ags, and intestinal pathogens. Dendritic cells (DCs) are believed to be involved in the induction of tolerance to harmless Ags and in mounting protective immune responses to pathogens and, as such, to play key roles in regulating intestinal immune homeostasis. The characterization of classical DCs (cDCs) in the intestinal lamina propria has been under intense investigation in recent years but the use of markers (including CD11c, CD11b, MHC class II), which are also expressed by intestinal MΦs, has led to some controversy regarding their definition. Here we review recent studies that help to distinguish cDCs subsets from... (More)
- The intestinal mucosa is exposed to large amounts of foreign antigen (Ag) derived from commensal bacteria, dietary Ags, and intestinal pathogens. Dendritic cells (DCs) are believed to be involved in the induction of tolerance to harmless Ags and in mounting protective immune responses to pathogens and, as such, to play key roles in regulating intestinal immune homeostasis. The characterization of classical DCs (cDCs) in the intestinal lamina propria has been under intense investigation in recent years but the use of markers (including CD11c, CD11b, MHC class II), which are also expressed by intestinal MΦs, has led to some controversy regarding their definition. Here we review recent studies that help to distinguish cDCs subsets from monocyte-derived cells in the intestinal mucosa. We address the phenotype and ontogeny of these cDC subsets and highlight recent findings indicating that these subsets play distinct roles in the regulation of mucosal immune responses in vivo. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4005419
- author
- Persson, Emma LU ; Scott, Charlotte L ; Mowat, Allan McI and Agace, William LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Immunology
- volume
- 43
- issue
- 12
- pages
- 3098 - 3107
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000328061600006
- pmid:23966272
- scopus:84893646173
- pmid:23966272
- ISSN
- 1521-4141
- DOI
- 10.1002/eji.201343740
- language
- English
- LU publication?
- yes
- id
- 7933da5f-4a89-4d81-9dca-81856a1261ef (old id 4005419)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23966272?dopt=Abstract
- date added to LUP
- 2016-04-01 10:00:32
- date last changed
- 2022-03-12 01:15:11
@article{7933da5f-4a89-4d81-9dca-81856a1261ef,
abstract = {{The intestinal mucosa is exposed to large amounts of foreign antigen (Ag) derived from commensal bacteria, dietary Ags, and intestinal pathogens. Dendritic cells (DCs) are believed to be involved in the induction of tolerance to harmless Ags and in mounting protective immune responses to pathogens and, as such, to play key roles in regulating intestinal immune homeostasis. The characterization of classical DCs (cDCs) in the intestinal lamina propria has been under intense investigation in recent years but the use of markers (including CD11c, CD11b, MHC class II), which are also expressed by intestinal MΦs, has led to some controversy regarding their definition. Here we review recent studies that help to distinguish cDCs subsets from monocyte-derived cells in the intestinal mucosa. We address the phenotype and ontogeny of these cDC subsets and highlight recent findings indicating that these subsets play distinct roles in the regulation of mucosal immune responses in vivo.}},
author = {{Persson, Emma and Scott, Charlotte L and Mowat, Allan McI and Agace, William}},
issn = {{1521-4141}},
language = {{eng}},
number = {{12}},
pages = {{3098--3107}},
publisher = {{John Wiley & Sons Inc.}},
series = {{European Journal of Immunology}},
title = {{Dendritic cell subsets in the intestinal lamina propria: Ontogeny and function.}},
url = {{http://dx.doi.org/10.1002/eji.201343740}},
doi = {{10.1002/eji.201343740}},
volume = {{43}},
year = {{2013}},
}