Solvent-free and biocompatible multiphased organic-inorganic hybrid nanocomposites
(2018) In Soft Matter 14(9). p.1709-1718- Abstract
Biocompatible chemically cross-linked organic-inorganic (O-I) hybrid nanocomposites were developed using a new atoxic, simple and fast, solvent-free pathway. Poly(ϵ-caprolactone) (PCL) and poly(ethylene glycol) (PEG), which are both biocompatible, were used as the organic moieties (at different PCL/PEG ratios), while in situ synthesized polysilsesquioxanes made up the inorganic moiety. The O-I hybrid nanocomposites' molecular structures were characterized using solid-state 29Si NMR, TGA and ATR-IR. Results showed an unusually high condensation yield of approximately 90% and two distinct silsesquioxane structures. No traces of the remaining isocyanate groups were found. Advanced morphological characterization of the ternary... (More)
Biocompatible chemically cross-linked organic-inorganic (O-I) hybrid nanocomposites were developed using a new atoxic, simple and fast, solvent-free pathway. Poly(ϵ-caprolactone) (PCL) and poly(ethylene glycol) (PEG), which are both biocompatible, were used as the organic moieties (at different PCL/PEG ratios), while in situ synthesized polysilsesquioxanes made up the inorganic moiety. The O-I hybrid nanocomposites' molecular structures were characterized using solid-state 29Si NMR, TGA and ATR-IR. Results showed an unusually high condensation yield of approximately 90% and two distinct silsesquioxane structures. No traces of the remaining isocyanate groups were found. Advanced morphological characterization of the ternary O-I hybrids was performed using a combination of electron microscopy and X-ray scattering techniques such as SEM, TEM, ESI-TEM, WAXS and temperature-dependent SAXS. Results showed the occurrence of spherical nanoparticles, associated with polysilsesquioxane, and ordered network grains, associated with PCL and/or PEG chains cross-linked by silsesquioxane cages. As a consequence, a four-phased nanostructured morphology was proposed. In this model, PCL and PEG are undistinguishable, while polysilsesquioxane nanoparticles are uniformly distributed throughout a homogeneous cross-linked matrix, which shows gel-like behavior. Moreover, a mobile phase made up of unbound polymer chains occurs at the grain interface.
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- author
- Da Silva, Laura C.E. ; Germiniani, Luiz G.L. ; Plivelic, Tomás S. LU and Gonçalves, Maria C.
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Soft Matter
- volume
- 14
- issue
- 9
- pages
- 10 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- scopus:85042687005
- pmid:29431831
- ISSN
- 1744-683X
- DOI
- 10.1039/c7sm02547e
- project
- Structural Characterization of Multicomponent Biodegradable Polymeric Systems by Synchrotron X-ray Scattering and Transmission Electron Microscopy
- language
- English
- LU publication?
- yes
- id
- 79375111-3d43-4315-9e24-1e50c450173f
- date added to LUP
- 2018-03-16 12:55:23
- date last changed
- 2024-06-10 09:31:16
@article{79375111-3d43-4315-9e24-1e50c450173f,
abstract = {{<p>Biocompatible chemically cross-linked organic-inorganic (O-I) hybrid nanocomposites were developed using a new atoxic, simple and fast, solvent-free pathway. Poly(ϵ-caprolactone) (PCL) and poly(ethylene glycol) (PEG), which are both biocompatible, were used as the organic moieties (at different PCL/PEG ratios), while in situ synthesized polysilsesquioxanes made up the inorganic moiety. The O-I hybrid nanocomposites' molecular structures were characterized using solid-state <sup>29</sup>Si NMR, TGA and ATR-IR. Results showed an unusually high condensation yield of approximately 90% and two distinct silsesquioxane structures. No traces of the remaining isocyanate groups were found. Advanced morphological characterization of the ternary O-I hybrids was performed using a combination of electron microscopy and X-ray scattering techniques such as SEM, TEM, ESI-TEM, WAXS and temperature-dependent SAXS. Results showed the occurrence of spherical nanoparticles, associated with polysilsesquioxane, and ordered network grains, associated with PCL and/or PEG chains cross-linked by silsesquioxane cages. As a consequence, a four-phased nanostructured morphology was proposed. In this model, PCL and PEG are undistinguishable, while polysilsesquioxane nanoparticles are uniformly distributed throughout a homogeneous cross-linked matrix, which shows gel-like behavior. Moreover, a mobile phase made up of unbound polymer chains occurs at the grain interface.</p>}},
author = {{Da Silva, Laura C.E. and Germiniani, Luiz G.L. and Plivelic, Tomás S. and Gonçalves, Maria C.}},
issn = {{1744-683X}},
language = {{eng}},
number = {{9}},
pages = {{1709--1718}},
publisher = {{Royal Society of Chemistry}},
series = {{Soft Matter}},
title = {{Solvent-free and biocompatible multiphased organic-inorganic hybrid nanocomposites}},
url = {{http://dx.doi.org/10.1039/c7sm02547e}},
doi = {{10.1039/c7sm02547e}},
volume = {{14}},
year = {{2018}},
}