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Solvent-free and biocompatible multiphased organic-inorganic hybrid nanocomposites

Da Silva, Laura C.E.; Germiniani, Luiz G.L.; Plivelic, Tomás S. LU and Gonçalves, Maria C. (2018) In Soft Matter 14(9). p.1709-1718
Abstract

Biocompatible chemically cross-linked organic-inorganic (O-I) hybrid nanocomposites were developed using a new atoxic, simple and fast, solvent-free pathway. Poly(ϵ-caprolactone) (PCL) and poly(ethylene glycol) (PEG), which are both biocompatible, were used as the organic moieties (at different PCL/PEG ratios), while in situ synthesized polysilsesquioxanes made up the inorganic moiety. The O-I hybrid nanocomposites' molecular structures were characterized using solid-state 29Si NMR, TGA and ATR-IR. Results showed an unusually high condensation yield of approximately 90% and two distinct silsesquioxane structures. No traces of the remaining isocyanate groups were found. Advanced morphological characterization of the ternary... (More)

Biocompatible chemically cross-linked organic-inorganic (O-I) hybrid nanocomposites were developed using a new atoxic, simple and fast, solvent-free pathway. Poly(ϵ-caprolactone) (PCL) and poly(ethylene glycol) (PEG), which are both biocompatible, were used as the organic moieties (at different PCL/PEG ratios), while in situ synthesized polysilsesquioxanes made up the inorganic moiety. The O-I hybrid nanocomposites' molecular structures were characterized using solid-state 29Si NMR, TGA and ATR-IR. Results showed an unusually high condensation yield of approximately 90% and two distinct silsesquioxane structures. No traces of the remaining isocyanate groups were found. Advanced morphological characterization of the ternary O-I hybrids was performed using a combination of electron microscopy and X-ray scattering techniques such as SEM, TEM, ESI-TEM, WAXS and temperature-dependent SAXS. Results showed the occurrence of spherical nanoparticles, associated with polysilsesquioxane, and ordered network grains, associated with PCL and/or PEG chains cross-linked by silsesquioxane cages. As a consequence, a four-phased nanostructured morphology was proposed. In this model, PCL and PEG are undistinguishable, while polysilsesquioxane nanoparticles are uniformly distributed throughout a homogeneous cross-linked matrix, which shows gel-like behavior. Moreover, a mobile phase made up of unbound polymer chains occurs at the grain interface.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Soft Matter
volume
14
issue
9
pages
10 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:85042687005
ISSN
1744-683X
DOI
10.1039/c7sm02547e
language
English
LU publication?
yes
id
79375111-3d43-4315-9e24-1e50c450173f
date added to LUP
2018-03-16 12:55:23
date last changed
2019-10-15 06:33:26
@article{79375111-3d43-4315-9e24-1e50c450173f,
  abstract     = {<p>Biocompatible chemically cross-linked organic-inorganic (O-I) hybrid nanocomposites were developed using a new atoxic, simple and fast, solvent-free pathway. Poly(ϵ-caprolactone) (PCL) and poly(ethylene glycol) (PEG), which are both biocompatible, were used as the organic moieties (at different PCL/PEG ratios), while in situ synthesized polysilsesquioxanes made up the inorganic moiety. The O-I hybrid nanocomposites' molecular structures were characterized using solid-state <sup>29</sup>Si NMR, TGA and ATR-IR. Results showed an unusually high condensation yield of approximately 90% and two distinct silsesquioxane structures. No traces of the remaining isocyanate groups were found. Advanced morphological characterization of the ternary O-I hybrids was performed using a combination of electron microscopy and X-ray scattering techniques such as SEM, TEM, ESI-TEM, WAXS and temperature-dependent SAXS. Results showed the occurrence of spherical nanoparticles, associated with polysilsesquioxane, and ordered network grains, associated with PCL and/or PEG chains cross-linked by silsesquioxane cages. As a consequence, a four-phased nanostructured morphology was proposed. In this model, PCL and PEG are undistinguishable, while polysilsesquioxane nanoparticles are uniformly distributed throughout a homogeneous cross-linked matrix, which shows gel-like behavior. Moreover, a mobile phase made up of unbound polymer chains occurs at the grain interface.</p>},
  author       = {Da Silva, Laura C.E. and Germiniani, Luiz G.L. and Plivelic, Tomás S. and Gonçalves, Maria C.},
  issn         = {1744-683X},
  language     = {eng},
  number       = {9},
  pages        = {1709--1718},
  publisher    = {Royal Society of Chemistry},
  series       = {Soft Matter},
  title        = {Solvent-free and biocompatible multiphased organic-inorganic hybrid nanocomposites},
  url          = {http://dx.doi.org/10.1039/c7sm02547e},
  volume       = {14},
  year         = {2018},
}