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Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight

Hurst, Carolyn D. ; Cheng, Guo ; Platt, Fiona M. ; Castro, Mauro A.A. ; Marzouka, Nour al dain S. LU ; Eriksson, Pontus LU ; Black, Emma V.I. ; Alder, Olivia ; Lawson, Andrew R.J. and Lindskrog, Sia V. , et al. (2021) In Cell Reports Medicine 2(12).
Abstract

Understanding the molecular determinants that underpin the clinical heterogeneity of non-muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy development. Stage T1 disease in particular presents a high risk of progression and requires improved understanding. We present a detailed multi-omics study containing gene expression, copy number, and mutational profiles that show relationships to immune infiltration, disease recurrence, and progression to muscle invasion. We compare expression and genomic subtypes derived from all NMIBCs with those derived from the individual disease stages Ta and T1. We show that sufficient molecular heterogeneity exists within the separate stages to allow subclassification and... (More)

Understanding the molecular determinants that underpin the clinical heterogeneity of non-muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy development. Stage T1 disease in particular presents a high risk of progression and requires improved understanding. We present a detailed multi-omics study containing gene expression, copy number, and mutational profiles that show relationships to immune infiltration, disease recurrence, and progression to muscle invasion. We compare expression and genomic subtypes derived from all NMIBCs with those derived from the individual disease stages Ta and T1. We show that sufficient molecular heterogeneity exists within the separate stages to allow subclassification and that this is more clinically meaningful for stage T1 disease than that derived from all NMIBCs. This provides improved biological understanding and identifies subtypes of T1 tumors that may benefit from chemo- or immunotherapy.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
classification, clinical outcome, copy number, genomics, NMIBC, non-muscle-invasive bladder cancer, PPAR gamma, stage T1, stage Ta, transcriptomics
in
Cell Reports Medicine
volume
2
issue
12
article number
100472
publisher
Elsevier
external identifiers
  • scopus:85121481080
  • pmid:35028613
ISSN
2666-3791
DOI
10.1016/j.xcrm.2021.100472
language
English
LU publication?
yes
id
794238a7-c32a-4730-b25c-b60d2a045d22
date added to LUP
2022-02-04 09:48:30
date last changed
2024-06-19 16:55:43
@article{794238a7-c32a-4730-b25c-b60d2a045d22,
  abstract     = {{<p>Understanding the molecular determinants that underpin the clinical heterogeneity of non-muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy development. Stage T1 disease in particular presents a high risk of progression and requires improved understanding. We present a detailed multi-omics study containing gene expression, copy number, and mutational profiles that show relationships to immune infiltration, disease recurrence, and progression to muscle invasion. We compare expression and genomic subtypes derived from all NMIBCs with those derived from the individual disease stages Ta and T1. We show that sufficient molecular heterogeneity exists within the separate stages to allow subclassification and that this is more clinically meaningful for stage T1 disease than that derived from all NMIBCs. This provides improved biological understanding and identifies subtypes of T1 tumors that may benefit from chemo- or immunotherapy.</p>}},
  author       = {{Hurst, Carolyn D. and Cheng, Guo and Platt, Fiona M. and Castro, Mauro A.A. and Marzouka, Nour al dain S. and Eriksson, Pontus and Black, Emma V.I. and Alder, Olivia and Lawson, Andrew R.J. and Lindskrog, Sia V. and Burns, Julie E. and Jain, Sunjay and Roulson, Jo An and Brown, Joanne C. and Koster, Jan and Robertson, A. Gordon and Martincorena, Inigo and Dyrskjøt, Lars and Höglund, Mattias and Knowles, Margaret A.}},
  issn         = {{2666-3791}},
  keywords     = {{classification; clinical outcome; copy number; genomics; NMIBC; non-muscle-invasive bladder cancer; PPAR gamma; stage T1; stage Ta; transcriptomics}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{12}},
  publisher    = {{Elsevier}},
  series       = {{Cell Reports Medicine}},
  title        = {{Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight}},
  url          = {{http://dx.doi.org/10.1016/j.xcrm.2021.100472}},
  doi          = {{10.1016/j.xcrm.2021.100472}},
  volume       = {{2}},
  year         = {{2021}},
}