Relationship between respiratory symptoms and medical treatment in exacerbations of COPD
(2005) In European Respiratory Journal 26(3). p.406-413- Abstract
- Exacerbations of chronic obstructive pulmonary disease (COPD) can be defined symptomatically or by healthcare contacts, yet the relationship between these events is unknown. Data were collected during a 1-yr study of the budesonide/formoterol combination in COPD patients, where exacerbations, defined by increases in treatment, were compared with daily records of respiratory symptoms, rescue medication use and peak expiratory flow (PEF). The relationship between changes in these variables and the medical event was examined using different modelling approaches. Data from the first exacerbation treated with oral corticosteroids and/or antibiotics and/or hospitalisation (event based) were available in 468 patients. Patients exacerbating were... (More)
- Exacerbations of chronic obstructive pulmonary disease (COPD) can be defined symptomatically or by healthcare contacts, yet the relationship between these events is unknown. Data were collected during a 1-yr study of the budesonide/formoterol combination in COPD patients, where exacerbations, defined by increases in treatment, were compared with daily records of respiratory symptoms, rescue medication use and peak expiratory flow (PEF). The relationship between changes in these variables and the medical event was examined using different modelling approaches. Data from the first exacerbation treated with oral corticosteroids and/or antibiotics and/or hospitalisation (event based) were available in 468 patients. Patients exacerbating were significantly more breathless and more likely to report cough than healthy patients, but did not differ in baseline spirometry. Exacerbations defined by changes in individual symptoms were only weakly related to event-based exacerbations; however, defined with 63% of such events being predicted from symptom changes. Changes in rescue medication use or PEF were poor predictors of event-based exacerbations. The mean peak change in symptoms was closely related to the onset of therapy. In conclusion, event-based exacerbations are a valid way of identifying acute symptom change in a chronic obstructive pulmonary disease population. However, daily symptom monitoring is too variable using the current diary cards to make individual management decisions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1133430
- author
- Calverley, P ; Pauwels Dagger, R ; Löfdahl, Claes-Göran LU ; Svensson, K ; Higenbottam, T ; Carlsson, L-G and Ståhl, Erik LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chronic obstructive pulmonary disease, concurrence, events, exacerbations, symptoms
- in
- European Respiratory Journal
- volume
- 26
- issue
- 3
- pages
- 406 - 413
- publisher
- European Respiratory Society
- external identifiers
-
- pmid:16135720
- wos:000231844000008
- scopus:24644458820
- pmid:16135720
- ISSN
- 1399-3003
- DOI
- 10.1183/09031936.05.00143404
- language
- English
- LU publication?
- yes
- id
- 794f562f-c9ad-46fe-a17d-036d617d0d8f (old id 1133430)
- date added to LUP
- 2016-04-01 11:59:07
- date last changed
- 2022-03-28 18:33:58
@article{794f562f-c9ad-46fe-a17d-036d617d0d8f,
abstract = {{Exacerbations of chronic obstructive pulmonary disease (COPD) can be defined symptomatically or by healthcare contacts, yet the relationship between these events is unknown. Data were collected during a 1-yr study of the budesonide/formoterol combination in COPD patients, where exacerbations, defined by increases in treatment, were compared with daily records of respiratory symptoms, rescue medication use and peak expiratory flow (PEF). The relationship between changes in these variables and the medical event was examined using different modelling approaches. Data from the first exacerbation treated with oral corticosteroids and/or antibiotics and/or hospitalisation (event based) were available in 468 patients. Patients exacerbating were significantly more breathless and more likely to report cough than healthy patients, but did not differ in baseline spirometry. Exacerbations defined by changes in individual symptoms were only weakly related to event-based exacerbations; however, defined with 63% of such events being predicted from symptom changes. Changes in rescue medication use or PEF were poor predictors of event-based exacerbations. The mean peak change in symptoms was closely related to the onset of therapy. In conclusion, event-based exacerbations are a valid way of identifying acute symptom change in a chronic obstructive pulmonary disease population. However, daily symptom monitoring is too variable using the current diary cards to make individual management decisions.}},
author = {{Calverley, P and Pauwels Dagger, R and Löfdahl, Claes-Göran and Svensson, K and Higenbottam, T and Carlsson, L-G and Ståhl, Erik}},
issn = {{1399-3003}},
keywords = {{Chronic obstructive pulmonary disease; concurrence; events; exacerbations; symptoms}},
language = {{eng}},
number = {{3}},
pages = {{406--413}},
publisher = {{European Respiratory Society}},
series = {{European Respiratory Journal}},
title = {{Relationship between respiratory symptoms and medical treatment in exacerbations of COPD}},
url = {{http://dx.doi.org/10.1183/09031936.05.00143404}},
doi = {{10.1183/09031936.05.00143404}},
volume = {{26}},
year = {{2005}},
}