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Nociceptive action of calcitonin gene-related peptide in the trigeminovascular system

Edvinsson, Lars LU and Edvinsson, Jacob C.A. LU (2026) In Nature Reviews Neurology
Abstract

Migraine treatments that target calcitonin gene-related peptide (CGRP) are widely used, but questions remain regarding their mechanisms and sites of action. Re-examination of the effects of CGRP in the trigeminovascular system has now refined our understanding of nociceptive CGRP signalling and underscores the importance of early therapeutic intervention.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Nature Reviews Neurology
publisher
Nature Publishing Group
external identifiers
  • scopus:105037335892
  • pmid:42045392
ISSN
1759-4758
DOI
10.1038/s41582-026-01214-x
language
English
LU publication?
yes
id
796cdae9-f6f9-4c79-a97e-49fde59ace82
date added to LUP
2026-06-29 11:40:46
date last changed
2026-09-08 23:19:32
@misc{796cdae9-f6f9-4c79-a97e-49fde59ace82,
  abstract     = {{<p>Migraine treatments that target calcitonin gene-related peptide (CGRP) are widely used, but questions remain regarding their mechanisms and sites of action. Re-examination of the effects of CGRP in the trigeminovascular system has now refined our understanding of nociceptive CGRP signalling and underscores the importance of early therapeutic intervention.</p>}},
  author       = {{Edvinsson, Lars and Edvinsson, Jacob C.A.}},
  issn         = {{1759-4758}},
  language     = {{eng}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Reviews Neurology}},
  title        = {{Nociceptive action of calcitonin gene-related peptide in the trigeminovascular system}},
  url          = {{http://dx.doi.org/10.1038/s41582-026-01214-x}},
  doi          = {{10.1038/s41582-026-01214-x}},
  year         = {{2026}},
}