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F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study

Mylam, Karen Juul; Kostakoglu, Lale; Hutchings, Martin; Coleman, Morton; Lamonica, Dominick; Czuczman, Myron S.; Diehl, Louis F.; Nielsen, Anne L.; Jensen, Paw and Loft, Annika, et al. (2015) In Leukemia & Lymphoma 56(7). p.2005-2012
Abstract
We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS>3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between... (More)
We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS>3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS>3. The 2-year PFS using D 5PS = 5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p = 0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET-positive and PET-negative patients in different prognostic groups. (Less)
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keywords
Deauville 5-point scale, diffuse large B-cell lymphoma, predictive value, Interim PET/CT
in
Leukemia & Lymphoma
volume
56
issue
7
pages
2005 - 2012
publisher
Taylor & Francis
external identifiers
  • wos:000359888700015
  • scopus:84938098851
ISSN
1042-8194
DOI
10.3109/10428194.2014.975800
language
English
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yes
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365ae29b-805d-4e2f-882a-934a93944df1 (old id 7972337)
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2015-10-01 07:36:41
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@article{365ae29b-805d-4e2f-882a-934a93944df1,
  abstract     = {We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS>3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS>3. The 2-year PFS using D 5PS = 5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p = 0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET-positive and PET-negative patients in different prognostic groups.},
  author       = {Mylam, Karen Juul and Kostakoglu, Lale and Hutchings, Martin and Coleman, Morton and Lamonica, Dominick and Czuczman, Myron S. and Diehl, Louis F. and Nielsen, Anne L. and Jensen, Paw and Loft, Annika and Hendel, Helle W. and Iyer, Victor and Leppa, Sirpa and Jyrkkio, Sirkku and Holte, Harald and Eriksson, Mikael and Gillstrom, Dorte and Hansen, Per B. and Seppanen, Marko and Hjorthaug, Karin and Brown, Peter de Nully and Pedersen, Lars M.},
  issn         = {1042-8194},
  keyword      = {Deauville 5-point scale,diffuse large B-cell lymphoma,predictive value,Interim PET/CT},
  language     = {eng},
  number       = {7},
  pages        = {2005--2012},
  publisher    = {Taylor & Francis},
  series       = {Leukemia & Lymphoma},
  title        = {F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study},
  url          = {http://dx.doi.org/10.3109/10428194.2014.975800},
  volume       = {56},
  year         = {2015},
}