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Graphene coatings for chemotherapy: avoiding silver-mediated degradation

Mazzola, Federico; Trinh, Thuat; Cooil, Simon; Ostli, Elise Ramleth; Hoydalsvik, Kristin; Skjonsfjell, Eirik Torbjorn Bakken; Kjelstrup, Signe; Preobrajenski, Alexei LU ; Cafolla, Attilio A. and Evans, D. Andrew, et al. (2015) In 2D Materials 2(2).
Abstract
Chemotherapy treatment usually involves the delivery of fluorouracil (5-Fu) together with other drugs through central venous catheters. Catheters and their connectors are increasingly treated with silver or argentic alloys/compounds. Complications arising from broken catheters are common, leading to additional suffering for patients and increased medical costs. Here, we uncover a likely cause of such failure through a study of the surface chemistry relevant to chemotherapy drug delivery, i.e. between 5-Fu and silver. We show that silver catalytically decomposes 5-Fu, compromising the efficacy of the chemotherapy treatment. Furthermore, HF is released as a product, which will be damaging to both patient and catheter. We demonstrate that... (More)
Chemotherapy treatment usually involves the delivery of fluorouracil (5-Fu) together with other drugs through central venous catheters. Catheters and their connectors are increasingly treated with silver or argentic alloys/compounds. Complications arising from broken catheters are common, leading to additional suffering for patients and increased medical costs. Here, we uncover a likely cause of such failure through a study of the surface chemistry relevant to chemotherapy drug delivery, i.e. between 5-Fu and silver. We show that silver catalytically decomposes 5-Fu, compromising the efficacy of the chemotherapy treatment. Furthermore, HF is released as a product, which will be damaging to both patient and catheter. We demonstrate that graphene surfaces inhibit this undesirable reaction and would offer superior performance as nanoscale coatings in cancer treatment applications. (Less)
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type
Contribution to journal
publication status
published
subject
keywords
photoemission, surface chemistry, fluorouracil, chemotherapy, graphene
in
2D Materials
volume
2
issue
2
publisher
IOP Publishing
external identifiers
  • wos:000359968200020
  • scopus:84948392717
ISSN
2053-1583
DOI
10.1088/2053-1583/2/2/025004
language
English
LU publication?
yes
id
80f59dfe-f1b7-4be1-ab31-7f7e328ddd86 (old id 7972361)
date added to LUP
2015-09-23 12:59:51
date last changed
2017-10-08 04:06:55
@article{80f59dfe-f1b7-4be1-ab31-7f7e328ddd86,
  abstract     = {Chemotherapy treatment usually involves the delivery of fluorouracil (5-Fu) together with other drugs through central venous catheters. Catheters and their connectors are increasingly treated with silver or argentic alloys/compounds. Complications arising from broken catheters are common, leading to additional suffering for patients and increased medical costs. Here, we uncover a likely cause of such failure through a study of the surface chemistry relevant to chemotherapy drug delivery, i.e. between 5-Fu and silver. We show that silver catalytically decomposes 5-Fu, compromising the efficacy of the chemotherapy treatment. Furthermore, HF is released as a product, which will be damaging to both patient and catheter. We demonstrate that graphene surfaces inhibit this undesirable reaction and would offer superior performance as nanoscale coatings in cancer treatment applications.},
  articleno    = {025004},
  author       = {Mazzola, Federico and Trinh, Thuat and Cooil, Simon and Ostli, Elise Ramleth and Hoydalsvik, Kristin and Skjonsfjell, Eirik Torbjorn Bakken and Kjelstrup, Signe and Preobrajenski, Alexei and Cafolla, Attilio A. and Evans, D. Andrew and Breiby, Dag W. and Wells, Justin W.},
  issn         = {2053-1583},
  keyword      = {photoemission,surface chemistry,fluorouracil,chemotherapy,graphene},
  language     = {eng},
  number       = {2},
  publisher    = {IOP Publishing},
  series       = {2D Materials},
  title        = {Graphene coatings for chemotherapy: avoiding silver-mediated degradation},
  url          = {http://dx.doi.org/10.1088/2053-1583/2/2/025004},
  volume       = {2},
  year         = {2015},
}