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High Turnover Catalase Activity of a Mixed-Valence (MnMnIII)-Mn-II Complex with Terminal Carboxylate Donors

Singh, Reena LU ; Haukka, Matti; McKenzie, Christine J. and Nordlander, Ebbe LU (2015) In European Journal of Inorganic Chemistry p.3485-3492
Abstract
The neutral dimanganese(II,III) complex [Mn-2(BCPMP)-(OAc)(2)] [1; BCPMP3- = 2,6-bis({(carboxymethyl)[(1-pyridyl)-methyl] amino} methyl)-4-methylphenolato] has been synthesized and characterized. The complex contains two terminal carboxylate donors. Complex 1 was found to be an effective catalyst for the disproportionation of H2O2 with high catalytic rate and a turnover number of 7500, the highest turnover reported to date for a catalase mimic. The rates and TON were significantly higher than recorded for a dicationic dimanganese( II,III) counterpart ([Mn-2(BPBP)(OAc)(2)]center dot(ClO4)(2), 2; BPBP- = 2,6-bis{[bis(2-pyridylmethyl)amino]methyl}-4-butylphen-olato), which lacks the terminal carboxylate donors, suggesting that introduction of... (More)
The neutral dimanganese(II,III) complex [Mn-2(BCPMP)-(OAc)(2)] [1; BCPMP3- = 2,6-bis({(carboxymethyl)[(1-pyridyl)-methyl] amino} methyl)-4-methylphenolato] has been synthesized and characterized. The complex contains two terminal carboxylate donors. Complex 1 was found to be an effective catalyst for the disproportionation of H2O2 with high catalytic rate and a turnover number of 7500, the highest turnover reported to date for a catalase mimic. The rates and TON were significantly higher than recorded for a dicationic dimanganese( II,III) counterpart ([Mn-2(BPBP)(OAc)(2)]center dot(ClO4)(2), 2; BPBP- = 2,6-bis{[bis(2-pyridylmethyl)amino]methyl}-4-butylphen-olato), which lacks the terminal carboxylate donors, suggesting that introduction of a terminal carboxylate donor improves activity. A well-resolved 16-line pattern obtained upon addition of H2O2 to complex 1 suggests involvement of an (MnMnIV)-Mn-III species in the catalytic cycle. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Catalase, Enzyme models, Manganese, Hydrogen peroxide, Dinucleating, ligands, Reaction mechanisms
in
European Journal of Inorganic Chemistry
issue
21
pages
3485 - 3492
publisher
John Wiley & Sons
external identifiers
  • wos:000359297800012
  • scopus:84938203500
ISSN
1099-0682
DOI
10.1002/ejic.201500468
language
English
LU publication?
yes
id
b121990c-b0e3-4f4a-8405-4281a053233a (old id 7975539)
date added to LUP
2015-09-24 15:03:23
date last changed
2017-01-01 03:33:32
@article{b121990c-b0e3-4f4a-8405-4281a053233a,
  abstract     = {The neutral dimanganese(II,III) complex [Mn-2(BCPMP)-(OAc)(2)] [1; BCPMP3- = 2,6-bis({(carboxymethyl)[(1-pyridyl)-methyl] amino} methyl)-4-methylphenolato] has been synthesized and characterized. The complex contains two terminal carboxylate donors. Complex 1 was found to be an effective catalyst for the disproportionation of H2O2 with high catalytic rate and a turnover number of 7500, the highest turnover reported to date for a catalase mimic. The rates and TON were significantly higher than recorded for a dicationic dimanganese( II,III) counterpart ([Mn-2(BPBP)(OAc)(2)]center dot(ClO4)(2), 2; BPBP- = 2,6-bis{[bis(2-pyridylmethyl)amino]methyl}-4-butylphen-olato), which lacks the terminal carboxylate donors, suggesting that introduction of a terminal carboxylate donor improves activity. A well-resolved 16-line pattern obtained upon addition of H2O2 to complex 1 suggests involvement of an (MnMnIV)-Mn-III species in the catalytic cycle.},
  author       = {Singh, Reena and Haukka, Matti and McKenzie, Christine J. and Nordlander, Ebbe},
  issn         = {1099-0682},
  keyword      = {Catalase,Enzyme models,Manganese,Hydrogen peroxide,Dinucleating,ligands,Reaction mechanisms},
  language     = {eng},
  number       = {21},
  pages        = {3485--3492},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Inorganic Chemistry},
  title        = {High Turnover Catalase Activity of a Mixed-Valence (MnMnIII)-Mn-II Complex with Terminal Carboxylate Donors},
  url          = {http://dx.doi.org/10.1002/ejic.201500468},
  year         = {2015},
}