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Distinct haplotype structure at the innate immune receptor Toll-like receptor 2 across bank vole populations and lineages in Europe

Morger, Jennifer; Råberg, Lars LU ; Hille, Sabine M.; Helsen, Sanne; Stefka, Jan; Al-Sabi, Mohammad M.; Kapel, Christian M. O.; Mappes, Tapio; Essbauer, Sandra and Ulrich, Rainer G., et al. (2015) In Biological Journal of the Linnean Society 116(1). p.124-133
Abstract
Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplotypes from all populations grouped in four clearly... (More)
Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplotypes from all populations grouped in four clearly differentiated clusters, with the three main clusters co-occurring in at least three previously described mitochondrial lineages. This pattern indicates that the distinct TLR2 haplotype structure may precede the split of the mitochondrial lineages 0.19-0.56Mya and suggests that haplotype clusters at this innate immune receptor are maintained over prolonged time in wild bank vole populations. (Less)
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published
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keywords
balancing selection, diversity, gene evolution, immunogenetics, maintenance of genetic variation, Myodes glareolus, parasite resistance, phylogeography, rodents, TLR2
in
Biological Journal of the Linnean Society
volume
116
issue
1
pages
124 - 133
publisher
Linnean Society of London
external identifiers
  • wos:000359294700010
  • scopus:84938749646
ISSN
0024-4066
DOI
10.1111/bij.12593
language
English
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yes
id
557515cc-4103-4d0e-9a5a-d8c61a6dfeb7 (old id 7975726)
date added to LUP
2015-09-25 10:41:17
date last changed
2017-01-08 03:40:45
@article{557515cc-4103-4d0e-9a5a-d8c61a6dfeb7,
  abstract     = {Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplotypes from all populations grouped in four clearly differentiated clusters, with the three main clusters co-occurring in at least three previously described mitochondrial lineages. This pattern indicates that the distinct TLR2 haplotype structure may precede the split of the mitochondrial lineages 0.19-0.56Mya and suggests that haplotype clusters at this innate immune receptor are maintained over prolonged time in wild bank vole populations.},
  author       = {Morger, Jennifer and Råberg, Lars and Hille, Sabine M. and Helsen, Sanne and Stefka, Jan and Al-Sabi, Mohammad M. and Kapel, Christian M. O. and Mappes, Tapio and Essbauer, Sandra and Ulrich, Rainer G. and Bartolommei, Paola and Mortelliti, Alessio and Balciauskas, Linas and van den Brink, Nico W. and Remy, Alice and Bajer, Anna and Cheprakov, Mihail and Korva, Misa and Garcia-Perez, Ana L. and Biek, Roman and Withenshaw, Susan and Tschirren, Barbara},
  issn         = {0024-4066},
  keyword      = {balancing selection,diversity,gene evolution,immunogenetics,maintenance of genetic variation,Myodes glareolus,parasite resistance,phylogeography,rodents,TLR2},
  language     = {eng},
  number       = {1},
  pages        = {124--133},
  publisher    = {Linnean Society of London},
  series       = {Biological Journal of the Linnean Society},
  title        = {Distinct haplotype structure at the innate immune receptor Toll-like receptor 2 across bank vole populations and lineages in Europe},
  url          = {http://dx.doi.org/10.1111/bij.12593},
  volume       = {116},
  year         = {2015},
}