Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Did introduction of pneumococcal vaccines in the Netherlands decrease the need for respiratory antibiotics in children? Analysis of 2002 to 2013 data

Gefenaite, G. LU orcid ; Bijlsma, M. J. ; Bos, H. J. and Hak, E. (2014) In Eurosurveillance 19(44). p.1-6
Abstract

To estimate the effect of the introduction of the 7- and 10-valentpneumococcal vaccines in 2006 and 2011, respectively in the Netherlands, we assessed respiratory antibiotic use in one to nine year-old children between 2002 and 2013. Seasonal autoregressive integrated moving-average models were applied to estimate the percentage reduction in respiratory antibiotic use. When compared with the pre-vaccination period, the proportion of respiratory antibiotic prescriptions fell by 4.94% (95% CI: 4.63 to 5.26) and 9.02% (95% CI: 2.83 to 14.82) after the introduction of the 7-valent vaccine in children aged three and four years, respectively. After the introduction of the 10-valent vaccine, we observed a reduction of 13.04% (95% CI: 2.76 to... (More)

To estimate the effect of the introduction of the 7- and 10-valentpneumococcal vaccines in 2006 and 2011, respectively in the Netherlands, we assessed respiratory antibiotic use in one to nine year-old children between 2002 and 2013. Seasonal autoregressive integrated moving-average models were applied to estimate the percentage reduction in respiratory antibiotic use. When compared with the pre-vaccination period, the proportion of respiratory antibiotic prescriptions fell by 4.94% (95% CI: 4.63 to 5.26) and 9.02% (95% CI: 2.83 to 14.82) after the introduction of the 7-valent vaccine in children aged three and four years, respectively. After the introduction of the 10-valent vaccine, we observed a reduction of 13.04% (95% CI: 2.76 to 22.23), 20.31% (95% CI: 13.50 to 26.58), 16.92% (95% CI: 3.07 to 28.80), 22.34% (95% CI: 3.73 to 37.35), 23.75% (95% CI: 2.37 to 40.44) in two, three, four, six and seven year-old children, respectively. Thus, our results indicate a reduction in respiratory antibiotic prescriptions in young children after introduction of the pneumococcal vaccines. As only children in our study population aged one and two years born after March 2011 had received the 10-valent vaccine, the effects of the 10-valent vaccine in children aged three to nine years likely reflect the effects of the 7-valent vaccine and herd immunity.

(Less)
Please use this url to cite or link to this publication:
author
; ; and
publishing date
type
Contribution to journal
publication status
published
in
Eurosurveillance
volume
19
issue
44
pages
1 - 6
publisher
European Centre for Disease Prevention and Control (ECDC)
external identifiers
  • scopus:84922031861
  • pmid:25394256
  • scopus:84922031861
ISSN
1560-7917
DOI
10.2807/1560-7917.ES2014.19.44.20948
project
Infectious diseases surveillance, vaccine effectiveness and determinants of acceptance
language
English
LU publication?
no
id
798ab472-6a34-4f10-9fab-bebca31a7c6a
date added to LUP
2023-02-02 10:30:49
date last changed
2024-01-03 21:57:52
@article{798ab472-6a34-4f10-9fab-bebca31a7c6a,
  abstract     = {{<p>To estimate the effect of the introduction of the 7- and 10-valentpneumococcal vaccines in 2006 and 2011, respectively in the Netherlands, we assessed respiratory antibiotic use in one to nine year-old children between 2002 and 2013. Seasonal autoregressive integrated moving-average models were applied to estimate the percentage reduction in respiratory antibiotic use. When compared with the pre-vaccination period, the proportion of respiratory antibiotic prescriptions fell by 4.94% (95% CI: 4.63 to 5.26) and 9.02% (95% CI: 2.83 to 14.82) after the introduction of the 7-valent vaccine in children aged three and four years, respectively. After the introduction of the 10-valent vaccine, we observed a reduction of 13.04% (95% CI: 2.76 to 22.23), 20.31% (95% CI: 13.50 to 26.58), 16.92% (95% CI: 3.07 to 28.80), 22.34% (95% CI: 3.73 to 37.35), 23.75% (95% CI: 2.37 to 40.44) in two, three, four, six and seven year-old children, respectively. Thus, our results indicate a reduction in respiratory antibiotic prescriptions in young children after introduction of the pneumococcal vaccines. As only children in our study population aged one and two years born after March 2011 had received the 10-valent vaccine, the effects of the 10-valent vaccine in children aged three to nine years likely reflect the effects of the 7-valent vaccine and herd immunity.</p>}},
  author       = {{Gefenaite, G. and Bijlsma, M. J. and Bos, H. J. and Hak, E.}},
  issn         = {{1560-7917}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{44}},
  pages        = {{1--6}},
  publisher    = {{European Centre for Disease Prevention and Control (ECDC)}},
  series       = {{Eurosurveillance}},
  title        = {{Did introduction of pneumococcal vaccines in the Netherlands decrease the need for respiratory antibiotics in children? Analysis of 2002 to 2013 data}},
  url          = {{http://dx.doi.org/10.2807/1560-7917.ES2014.19.44.20948}},
  doi          = {{10.2807/1560-7917.ES2014.19.44.20948}},
  volume       = {{19}},
  year         = {{2014}},
}