Complementarity-determining region (CDR) implantation : A theme of recombination
(1999) In Immunotechnology 4(3-4). p.279-285- Abstract
A novel technology in the area of antibody engineering has been developed which allows for the creation of new types of antibody molecules. It is called complementarity-determining region (CDR) implantation and permits the random combination of CDR sequences formed in vivo into a single master framework. Thus, totally new gene combinations can be produced and used in selection processes. The result is a genetic variability which is extremely large, even exceeding the natural variability found in the immune system. In this commentary, CDR implantation is presented and the technology is discussed.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/79b433e1-c0f9-4e10-b092-3e9503d4b425
- author
- Söderlind, Eskil LU ; Ohlin, Mats LU and Carlsson, Roland LU
- organization
- publishing date
- 1999-03
- type
- Contribution to journal
- publication status
- published
- keywords
- Antibody engineering, CDR implantation, Complementarity-determining region, Genetic variation
- in
- Immunotechnology
- volume
- 4
- issue
- 3-4
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0033103199
- pmid:10231097
- ISSN
- 1380-2933
- DOI
- 10.1016/S1380-2933(98)00027-X
- language
- English
- LU publication?
- yes
- id
- 79b433e1-c0f9-4e10-b092-3e9503d4b425
- date added to LUP
- 2016-04-19 14:04:18
- date last changed
- 2024-01-03 23:58:07
@article{79b433e1-c0f9-4e10-b092-3e9503d4b425, abstract = {{<p>A novel technology in the area of antibody engineering has been developed which allows for the creation of new types of antibody molecules. It is called complementarity-determining region (CDR) implantation and permits the random combination of CDR sequences formed in vivo into a single master framework. Thus, totally new gene combinations can be produced and used in selection processes. The result is a genetic variability which is extremely large, even exceeding the natural variability found in the immune system. In this commentary, CDR implantation is presented and the technology is discussed.</p>}}, author = {{Söderlind, Eskil and Ohlin, Mats and Carlsson, Roland}}, issn = {{1380-2933}}, keywords = {{Antibody engineering; CDR implantation; Complementarity-determining region; Genetic variation}}, language = {{eng}}, number = {{3-4}}, pages = {{279--285}}, publisher = {{Elsevier}}, series = {{Immunotechnology}}, title = {{Complementarity-determining region (CDR) implantation : A theme of recombination}}, url = {{http://dx.doi.org/10.1016/S1380-2933(98)00027-X}}, doi = {{10.1016/S1380-2933(98)00027-X}}, volume = {{4}}, year = {{1999}}, }