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Modeling psychiatric disorders : from genomic findings to cellular phenotypes

Falk, A LU ; Heine, V M ; Harwood, A J ; Sullivan, P F ; Peitz, M ; Brüstle, O ; Shen, S LU ; Sun, Y-M LU ; Glover, J C and Posthuma, D , et al. (2016) In Molecular Psychiatry 21(9). p.79-1167
Abstract

Major programs in psychiatric genetics have identified >150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features of psychiatric disorders have not yet been determined. Recent advances in genetics and stem cell biology offer new prospects for cell-based modeling of psychiatric disorders. The advent of cell reprogramming and induced pluripotent stem cells (iPSC) provides an opportunity to translate genetic findings into patient-specific in vitro models. iPSC technology is... (More)

Major programs in psychiatric genetics have identified >150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features of psychiatric disorders have not yet been determined. Recent advances in genetics and stem cell biology offer new prospects for cell-based modeling of psychiatric disorders. The advent of cell reprogramming and induced pluripotent stem cells (iPSC) provides an opportunity to translate genetic findings into patient-specific in vitro models. iPSC technology is less than a decade old but holds great promise for bridging the gaps between patients, genetics and biology. Despite many obvious advantages, iPSC studies still present multiple challenges. In this expert review, we critically review the challenges for modeling of psychiatric disorders, potential solutions and how iPSC technology can be used to develop an analytical framework for the evaluation and therapeutic manipulation of fundamental disease processes.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autistic Disorder/metabolism, Cellular Reprogramming, Genomics, Humans, Induced Pluripotent Stem Cells/metabolism, Mental Disorders/genetics, Models, Biological, Schizophrenia/metabolism
in
Molecular Psychiatry
volume
21
issue
9
pages
13 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:27240529
  • scopus:84973129416
ISSN
1359-4184
DOI
10.1038/mp.2016.89
language
English
LU publication?
no
id
79bb51c5-4fb6-4457-b2fc-e84e79a68fa0
date added to LUP
2021-08-10 14:18:18
date last changed
2024-06-15 15:04:26
@article{79bb51c5-4fb6-4457-b2fc-e84e79a68fa0,
  abstract     = {{<p>Major programs in psychiatric genetics have identified &gt;150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features of psychiatric disorders have not yet been determined. Recent advances in genetics and stem cell biology offer new prospects for cell-based modeling of psychiatric disorders. The advent of cell reprogramming and induced pluripotent stem cells (iPSC) provides an opportunity to translate genetic findings into patient-specific in vitro models. iPSC technology is less than a decade old but holds great promise for bridging the gaps between patients, genetics and biology. Despite many obvious advantages, iPSC studies still present multiple challenges. In this expert review, we critically review the challenges for modeling of psychiatric disorders, potential solutions and how iPSC technology can be used to develop an analytical framework for the evaluation and therapeutic manipulation of fundamental disease processes.</p>}},
  author       = {{Falk, A and Heine, V M and Harwood, A J and Sullivan, P F and Peitz, M and Brüstle, O and Shen, S and Sun, Y-M and Glover, J C and Posthuma, D and Djurovic, S}},
  issn         = {{1359-4184}},
  keywords     = {{Autistic Disorder/metabolism; Cellular Reprogramming; Genomics; Humans; Induced Pluripotent Stem Cells/metabolism; Mental Disorders/genetics; Models, Biological; Schizophrenia/metabolism}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{79--1167}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Molecular Psychiatry}},
  title        = {{Modeling psychiatric disorders : from genomic findings to cellular phenotypes}},
  url          = {{https://lup.lub.lu.se/search/files/101078633/Modeling_psychiatric_disorders.pdf}},
  doi          = {{10.1038/mp.2016.89}},
  volume       = {{21}},
  year         = {{2016}},
}