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In vivo diffusion MRI of the human heart using a 300 mT/m gradient system

Afzali, Maryam ; Mueller, Lars ; Coveney, Sam ; Fasano, Fabrizio ; Evans, Christopher John ; Engel, Maria ; Szczepankiewicz, Filip LU orcid ; Teh, Irvin ; Dall'Armellina, Erica and Jones, Derek K. , et al. (2024) In Magnetic Resonance in Medicine
Abstract

Purpose: This work reports for the first time on the implementation and application of cardiac diffusion-weighted MRI on a Connectom MR scanner with a maximum gradient strength of 300 mT/m. It evaluates the benefits of the increased gradient performance for the investigation of the myocardial microstructure. Methods: Cardiac diffusion-weighted imaging (DWI) experiments were performed on 10 healthy volunteers using a spin-echo sequence with up to second- and third-order motion compensation ((Formula presented.) and (Formula presented.)) and (Formula presented.), and 1000 (Formula presented.) (twice the (Formula presented.) commonly used on clinical scanners). Mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and... (More)

Purpose: This work reports for the first time on the implementation and application of cardiac diffusion-weighted MRI on a Connectom MR scanner with a maximum gradient strength of 300 mT/m. It evaluates the benefits of the increased gradient performance for the investigation of the myocardial microstructure. Methods: Cardiac diffusion-weighted imaging (DWI) experiments were performed on 10 healthy volunteers using a spin-echo sequence with up to second- and third-order motion compensation ((Formula presented.) and (Formula presented.)) and (Formula presented.), and 1000 (Formula presented.) (twice the (Formula presented.) commonly used on clinical scanners). Mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and secondary eigenvector angle (E2A) were calculated for b = [100, 450] (Formula presented.) and b = [100, 1000] (Formula presented.) for both (Formula presented.) and (Formula presented.). Results: The MD values with (Formula presented.) are slightly higher than with (Formula presented.) with (Formula presented.) for (Formula presented.) and (Formula presented.) for (Formula presented.). A reduction in MD is observed by increasing the (Formula presented.) from 450 to 1000 (Formula presented.) ((Formula presented.) for (Formula presented.) and (Formula presented.) for (Formula presented.)). The difference between FA, E2A, and HA was not significant in different schemes ((Formula presented.)). Conclusion: This work demonstrates cardiac DWI in vivo with higher b-value and higher order of motion compensated diffusion gradient waveforms than is commonly used. Increasing the motion compensation order from (Formula presented.) to (Formula presented.) and the maximum b-value from 450 to 1000 (Formula presented.) affected the MD values but FA and the angular metrics (HA and E2A) remained unchanged. Our work paves the way for cardiac DWI on the next-generation MR scanners with high-performance gradient systems.

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organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
cardiac diffusion MRI, higher-order motion compensation, strong gradients
in
Magnetic Resonance in Medicine
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:38650395
  • scopus:85191179267
ISSN
0740-3194
DOI
10.1002/mrm.30118
language
English
LU publication?
yes
id
79cf37fb-0e4f-4641-97e2-94a96d9842a8
date added to LUP
2024-05-06 08:31:01
date last changed
2024-05-07 03:00:42
@article{79cf37fb-0e4f-4641-97e2-94a96d9842a8,
  abstract     = {{<p>Purpose: This work reports for the first time on the implementation and application of cardiac diffusion-weighted MRI on a Connectom MR scanner with a maximum gradient strength of 300 mT/m. It evaluates the benefits of the increased gradient performance for the investigation of the myocardial microstructure. Methods: Cardiac diffusion-weighted imaging (DWI) experiments were performed on 10 healthy volunteers using a spin-echo sequence with up to second- and third-order motion compensation ((Formula presented.) and (Formula presented.)) and (Formula presented.), and 1000 (Formula presented.) (twice the (Formula presented.) commonly used on clinical scanners). Mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and secondary eigenvector angle (E2A) were calculated for b = [100, 450] (Formula presented.) and b = [100, 1000] (Formula presented.) for both (Formula presented.) and (Formula presented.). Results: The MD values with (Formula presented.) are slightly higher than with (Formula presented.) with (Formula presented.) for (Formula presented.) and (Formula presented.) for (Formula presented.). A reduction in MD is observed by increasing the (Formula presented.) from 450 to 1000 (Formula presented.) ((Formula presented.) for (Formula presented.) and (Formula presented.) for (Formula presented.)). The difference between FA, E2A, and HA was not significant in different schemes ((Formula presented.)). Conclusion: This work demonstrates cardiac DWI in vivo with higher b-value and higher order of motion compensated diffusion gradient waveforms than is commonly used. Increasing the motion compensation order from (Formula presented.) to (Formula presented.) and the maximum b-value from 450 to 1000 (Formula presented.) affected the MD values but FA and the angular metrics (HA and E2A) remained unchanged. Our work paves the way for cardiac DWI on the next-generation MR scanners with high-performance gradient systems.</p>}},
  author       = {{Afzali, Maryam and Mueller, Lars and Coveney, Sam and Fasano, Fabrizio and Evans, Christopher John and Engel, Maria and Szczepankiewicz, Filip and Teh, Irvin and Dall'Armellina, Erica and Jones, Derek K. and Schneider, Jürgen E.}},
  issn         = {{0740-3194}},
  keywords     = {{cardiac diffusion MRI; higher-order motion compensation; strong gradients}},
  language     = {{eng}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Magnetic Resonance in Medicine}},
  title        = {{In vivo diffusion MRI of the human heart using a 300 mT/m gradient system}},
  url          = {{http://dx.doi.org/10.1002/mrm.30118}},
  doi          = {{10.1002/mrm.30118}},
  year         = {{2024}},
}