Swelling kinetics of mixtures of soybean phosphatidylcholine and glycerol dioleate
(2024) In Colloids and Surfaces B: Biointerfaces 239.- Abstract
Lipid-based drug delivery systems offer the potential to enhance bioavailability, reduce dosing frequency, and improve patient adherence. In aqueous environment, initially dry lipid depots take up water and form liquid crystalline phases. Variation of lipid composition, depot size and hydration-induced phase transitions will plausibly affect the diffusion in and out of the depot. Lipid depots of soybean phosphatidylcholine (SPC) and glycerol dioleate (GDO) mixtures were hydrated for varying time durations in a phosphate-buffered saline (PBS) buffer and then analyzed with Karl Fischer titration, magnetic resonance imaging (MRI) and gravimetrically. Mathematical modeling of the swelling process using diffusion equations, was used to... (More)
Lipid-based drug delivery systems offer the potential to enhance bioavailability, reduce dosing frequency, and improve patient adherence. In aqueous environment, initially dry lipid depots take up water and form liquid crystalline phases. Variation of lipid composition, depot size and hydration-induced phase transitions will plausibly affect the diffusion in and out of the depot. Lipid depots of soybean phosphatidylcholine (SPC) and glycerol dioleate (GDO) mixtures were hydrated for varying time durations in a phosphate-buffered saline (PBS) buffer and then analyzed with Karl Fischer titration, magnetic resonance imaging (MRI) and gravimetrically. Mathematical modeling of the swelling process using diffusion equations, was used to estimate the parameters of diffusion. Both composition of lipid mixture and depot size affect swelling kinetics… The diffusion parameters obtained in Karl Fischer titration and MRI (with temporal and spatial resolution respectively) are in good agreement. Remarkably, the MRI results show a gradient of water content within the depot even after the end of diffusion process. Apparently contradicting the first Fick's law in its classical form, these results find an explanation using the generalized Fick's law that considers the gradient of chemical potential rather than concentration as the driving force of diffusion.
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- author
- Engstedt, Jenni
; in 't Zandt, René
LU
; Barauskas, Justas LU and Kocherbitov, Vitaly LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Generalized Fick's law, Hydration, Lipid liquid crystalline depot, Magnetic resonance imaging, Phase equilibria, Swelling kinetics
- in
- Colloids and Surfaces B: Biointerfaces
- volume
- 239
- article number
- 113955
- publisher
- Elsevier
- external identifiers
-
- pmid:38754200
- scopus:85192715443
- ISSN
- 0927-7765
- DOI
- 10.1016/j.colsurfb.2024.113955
- language
- English
- LU publication?
- yes
- id
- 7a8d65ca-a8df-465d-a118-6231c2797db2
- date added to LUP
- 2024-05-28 15:55:55
- date last changed
- 2024-06-11 16:50:25
@article{7a8d65ca-a8df-465d-a118-6231c2797db2, abstract = {{<p>Lipid-based drug delivery systems offer the potential to enhance bioavailability, reduce dosing frequency, and improve patient adherence. In aqueous environment, initially dry lipid depots take up water and form liquid crystalline phases. Variation of lipid composition, depot size and hydration-induced phase transitions will plausibly affect the diffusion in and out of the depot. Lipid depots of soybean phosphatidylcholine (SPC) and glycerol dioleate (GDO) mixtures were hydrated for varying time durations in a phosphate-buffered saline (PBS) buffer and then analyzed with Karl Fischer titration, magnetic resonance imaging (MRI) and gravimetrically. Mathematical modeling of the swelling process using diffusion equations, was used to estimate the parameters of diffusion. Both composition of lipid mixture and depot size affect swelling kinetics… The diffusion parameters obtained in Karl Fischer titration and MRI (with temporal and spatial resolution respectively) are in good agreement. Remarkably, the MRI results show a gradient of water content within the depot even after the end of diffusion process. Apparently contradicting the first Fick's law in its classical form, these results find an explanation using the generalized Fick's law that considers the gradient of chemical potential rather than concentration as the driving force of diffusion.</p>}}, author = {{Engstedt, Jenni and in 't Zandt, René and Barauskas, Justas and Kocherbitov, Vitaly}}, issn = {{0927-7765}}, keywords = {{Generalized Fick's law; Hydration; Lipid liquid crystalline depot; Magnetic resonance imaging; Phase equilibria; Swelling kinetics}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Colloids and Surfaces B: Biointerfaces}}, title = {{Swelling kinetics of mixtures of soybean phosphatidylcholine and glycerol dioleate}}, url = {{http://dx.doi.org/10.1016/j.colsurfb.2024.113955}}, doi = {{10.1016/j.colsurfb.2024.113955}}, volume = {{239}}, year = {{2024}}, }