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Behavioral and Psychological Symptoms of Dementia in Different Dementia Disorders : A Large-Scale Study of 10,000 Individuals

Schwertner, Emilia ; Pereira, Joana B. LU ; Xu, Hong ; Secnik, Juraj ; Winblad, Bengt ; Eriksdotter, Maria ; Nägga, Katarina LU and Religa, Dorota (2022) In Journal of Alzheimer's Disease 87(3). p.1307-1318
Abstract

Background: The majority of individuals with dementia will suffer from behavioral and psychological symptoms of dementia (BPSD). These symptoms contribute to functional impairment and caregiver burden. Objective: To characterize BPSD in Alzheimer's disease (AD), vascular dementia (VaD), mixed (Mixed) dementia, Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and unspecified dementia in individuals residing in long-term care facilities. Methods: We included 10,405 individuals with dementia living in long-term care facilities from the Swedish registry for cognitive/dementia disorders (SveDem) and the Swedish BPSD registry. BPSD was assessed with the Neuropsychiatric Inventory - Nursing... (More)

Background: The majority of individuals with dementia will suffer from behavioral and psychological symptoms of dementia (BPSD). These symptoms contribute to functional impairment and caregiver burden. Objective: To characterize BPSD in Alzheimer's disease (AD), vascular dementia (VaD), mixed (Mixed) dementia, Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and unspecified dementia in individuals residing in long-term care facilities. Methods: We included 10,405 individuals with dementia living in long-term care facilities from the Swedish registry for cognitive/dementia disorders (SveDem) and the Swedish BPSD registry. BPSD was assessed with the Neuropsychiatric Inventory - Nursing Home Version (NPI-NH). Multivariate logistic regression models were used to evaluate the associations between dementia diagnoses and different BPSDs. Results: The most common symptoms were aberrant motor behavior, agitation, and irritability. Compared to AD, we found a lower risk of delusions (in FTD, unspecified dementia), hallucinations (FTD), agitation (VaD, PDD, unspecified dementia), elation/euphoria (DLB), anxiety (Mixed, VaD, unspecified dementia), disinhibition (in PDD), irritability (in DLB, FTD, unspecified dementia), aberrant motor behavior (Mixed, VaD, unspecified dementia), and sleep and night-time behavior changes (unspecified dementia). Higher risk of delusions (DLB), hallucinations (DLB, PDD), apathy (VaD, FTD), disinhibition (FTD), and appetite and eating abnormalities (FTD) were also found in comparison to AD. Conclusion: Although individuals in our sample were diagnosed with different dementia disorders, they all exhibited aberrant motor behavior, agitation, and irritability. This suggests common underlying psychosocial or biological mechanisms. We recommend prioritizing these symptoms while planning interventions in long-term care facilities.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aberrant motor behavior, aging, agitation, Alzheimer's disease, behavioral and psychological symptoms of dementia, behavioral problem, dementia, irritability, Neuropsychiatric Inventory, nursing homes
in
Journal of Alzheimer's Disease
volume
87
issue
3
pages
12 pages
publisher
IOS Press
external identifiers
  • pmid:35491774
  • scopus:85131290963
ISSN
1387-2877
DOI
10.3233/JAD-215198
language
English
LU publication?
yes
id
7a923279-02ad-4747-818a-b7ba44ced2ec
date added to LUP
2022-08-19 17:20:33
date last changed
2024-04-18 06:05:49
@article{7a923279-02ad-4747-818a-b7ba44ced2ec,
  abstract     = {{<p>Background: The majority of individuals with dementia will suffer from behavioral and psychological symptoms of dementia (BPSD). These symptoms contribute to functional impairment and caregiver burden. Objective: To characterize BPSD in Alzheimer's disease (AD), vascular dementia (VaD), mixed (Mixed) dementia, Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and unspecified dementia in individuals residing in long-term care facilities. Methods: We included 10,405 individuals with dementia living in long-term care facilities from the Swedish registry for cognitive/dementia disorders (SveDem) and the Swedish BPSD registry. BPSD was assessed with the Neuropsychiatric Inventory - Nursing Home Version (NPI-NH). Multivariate logistic regression models were used to evaluate the associations between dementia diagnoses and different BPSDs. Results: The most common symptoms were aberrant motor behavior, agitation, and irritability. Compared to AD, we found a lower risk of delusions (in FTD, unspecified dementia), hallucinations (FTD), agitation (VaD, PDD, unspecified dementia), elation/euphoria (DLB), anxiety (Mixed, VaD, unspecified dementia), disinhibition (in PDD), irritability (in DLB, FTD, unspecified dementia), aberrant motor behavior (Mixed, VaD, unspecified dementia), and sleep and night-time behavior changes (unspecified dementia). Higher risk of delusions (DLB), hallucinations (DLB, PDD), apathy (VaD, FTD), disinhibition (FTD), and appetite and eating abnormalities (FTD) were also found in comparison to AD. Conclusion: Although individuals in our sample were diagnosed with different dementia disorders, they all exhibited aberrant motor behavior, agitation, and irritability. This suggests common underlying psychosocial or biological mechanisms. We recommend prioritizing these symptoms while planning interventions in long-term care facilities. </p>}},
  author       = {{Schwertner, Emilia and Pereira, Joana B. and Xu, Hong and Secnik, Juraj and Winblad, Bengt and Eriksdotter, Maria and Nägga, Katarina and Religa, Dorota}},
  issn         = {{1387-2877}},
  keywords     = {{Aberrant motor behavior; aging; agitation; Alzheimer's disease; behavioral and psychological symptoms of dementia; behavioral problem; dementia; irritability; Neuropsychiatric Inventory; nursing homes}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1307--1318}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Alzheimer's Disease}},
  title        = {{Behavioral and Psychological Symptoms of Dementia in Different Dementia Disorders : A Large-Scale Study of 10,000 Individuals}},
  url          = {{http://dx.doi.org/10.3233/JAD-215198}},
  doi          = {{10.3233/JAD-215198}},
  volume       = {{87}},
  year         = {{2022}},
}