Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The Resection Rate of Synchronously Detected Liver and Lung Metastasis from Colorectal Cancer Is Low-A National Registry-Based Study

Engstrand, Jennie ; Taflin, Helena ; Rystedt, Jenny Lundmark LU ; Hemmingsson, Oskar ; Urdzik, Jozef ; Sandström, Per ; Björnsson, Bergthor and Hasselgren, Kristina (2023) In Cancers 15(5).
Abstract

Population-based data on the incidence and surgical treatment of patients with colorectal cancer (CRC) and synchronous liver and lung metastases are lacking as are real-life data on the frequency of metastasectomy for both sites and outcomes in this setting. This is a nationwide population-based study of all patients having liver and lung metastases diagnosed within 6 months of CRC between 2008 and 2016 in Sweden identified through the merging of data from the National Quality Registries on CRC, liver and thoracic surgery and the National Patient Registry. Among 60,734 patients diagnosed with CRC, 1923 (3.2%) had synchronous liver and lung metastases, of which 44 patients had complete metastasectomy. Surgery of liver and lung metastases... (More)

Population-based data on the incidence and surgical treatment of patients with colorectal cancer (CRC) and synchronous liver and lung metastases are lacking as are real-life data on the frequency of metastasectomy for both sites and outcomes in this setting. This is a nationwide population-based study of all patients having liver and lung metastases diagnosed within 6 months of CRC between 2008 and 2016 in Sweden identified through the merging of data from the National Quality Registries on CRC, liver and thoracic surgery and the National Patient Registry. Among 60,734 patients diagnosed with CRC, 1923 (3.2%) had synchronous liver and lung metastases, of which 44 patients had complete metastasectomy. Surgery of liver and lung metastases yielded a 5-year OS of 74% (95% CI 57-85%) compared to 29% (95% CI 19-40%) if liver metastases were resected but not the lung metastases and 2.6% (95% CI 1.5-4%) if non-resected, p < 0.001. Complete resection rates ranged from 0.7% to 3.8% between the six healthcare regions of Sweden, p = 0.007. Synchronous liver and lung CRC metastases are rare, and a minority undergo the resection of both metastatic sites but with excellent survival. The reasons for differences in regional treatment approaches and the potential of increased resection rates should be studied further.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancers
volume
15
issue
5
article number
1434
publisher
MDPI AG
external identifiers
  • scopus:85149850000
  • pmid:36900225
ISSN
2072-6694
DOI
10.3390/cancers15051434
language
English
LU publication?
yes
id
7b630b9e-411f-4135-a274-250d796e90d5
date added to LUP
2023-03-13 13:36:27
date last changed
2024-04-19 20:24:54
@article{7b630b9e-411f-4135-a274-250d796e90d5,
  abstract     = {{<p>Population-based data on the incidence and surgical treatment of patients with colorectal cancer (CRC) and synchronous liver and lung metastases are lacking as are real-life data on the frequency of metastasectomy for both sites and outcomes in this setting. This is a nationwide population-based study of all patients having liver and lung metastases diagnosed within 6 months of CRC between 2008 and 2016 in Sweden identified through the merging of data from the National Quality Registries on CRC, liver and thoracic surgery and the National Patient Registry. Among 60,734 patients diagnosed with CRC, 1923 (3.2%) had synchronous liver and lung metastases, of which 44 patients had complete metastasectomy. Surgery of liver and lung metastases yielded a 5-year OS of 74% (95% CI 57-85%) compared to 29% (95% CI 19-40%) if liver metastases were resected but not the lung metastases and 2.6% (95% CI 1.5-4%) if non-resected, p &lt; 0.001. Complete resection rates ranged from 0.7% to 3.8% between the six healthcare regions of Sweden, p = 0.007. Synchronous liver and lung CRC metastases are rare, and a minority undergo the resection of both metastatic sites but with excellent survival. The reasons for differences in regional treatment approaches and the potential of increased resection rates should be studied further.</p>}},
  author       = {{Engstrand, Jennie and Taflin, Helena and Rystedt, Jenny Lundmark and Hemmingsson, Oskar and Urdzik, Jozef and Sandström, Per and Björnsson, Bergthor and Hasselgren, Kristina}},
  issn         = {{2072-6694}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{5}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{The Resection Rate of Synchronously Detected Liver and Lung Metastasis from Colorectal Cancer Is Low-A National Registry-Based Study}},
  url          = {{http://dx.doi.org/10.3390/cancers15051434}},
  doi          = {{10.3390/cancers15051434}},
  volume       = {{15}},
  year         = {{2023}},
}