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Boronic Acid Modified Polymer Nanoparticles for Enhanced Bacterial Deactivation

Gong, Haiyue LU ; Liu, Weifeng ; Carlquist, Magnus LU and Ye, Lei LU orcid (2019) In ChemBioChem 20(24). p.2991-2995
Abstract
A new method has been developed to enhance the antibacterial efficiency of traditional antibiotics. Chloramphenicol‐imprinted polymer particles were decorated with boronic acid to improve their binding to both Gram‐negative and ‐positive bacteria. The polymer particles have a high antibiotic loading and provide a slow release of the antibiotic payload to deactivate the target bacteria. The boronic acid modified polymer particles not only contribute to enhanced antibacterial efficiency, but also have the potential to act as scavengers to remove unused antibiotic from the environment.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antibiotics, drug delivery, molecular imprinting, polymers, template synthesis
in
ChemBioChem
volume
20
issue
24
pages
5 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:31243881
  • scopus:85074373084
ISSN
1439-4227
DOI
10.1002/cbic.201900406
language
English
LU publication?
yes
id
7b89dd42-2361-4499-a269-68fdbb215ae2
date added to LUP
2020-08-09 11:52:30
date last changed
2022-04-03 04:11:12
@article{7b89dd42-2361-4499-a269-68fdbb215ae2,
  abstract     = {{A new method has been developed to enhance the antibacterial efficiency of traditional antibiotics. Chloramphenicol‐imprinted polymer particles were decorated with boronic acid to improve their binding to both Gram‐negative and ‐positive bacteria. The polymer particles have a high antibiotic loading and provide a slow release of the antibiotic payload to deactivate the target bacteria. The boronic acid modified polymer particles not only contribute to enhanced antibacterial efficiency, but also have the potential to act as scavengers to remove unused antibiotic from the environment.}},
  author       = {{Gong, Haiyue and Liu, Weifeng and Carlquist, Magnus and Ye, Lei}},
  issn         = {{1439-4227}},
  keywords     = {{antibiotics; drug delivery; molecular imprinting; polymers; template synthesis}},
  language     = {{eng}},
  number       = {{24}},
  pages        = {{2991--2995}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{ChemBioChem}},
  title        = {{Boronic Acid Modified Polymer Nanoparticles for Enhanced Bacterial Deactivation}},
  url          = {{http://dx.doi.org/10.1002/cbic.201900406}},
  doi          = {{10.1002/cbic.201900406}},
  volume       = {{20}},
  year         = {{2019}},
}