Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Novel insights into the emerging roles of tRNA-derived fragments in mammalian development

Guzzi, Nicola LU and Bellodi, Cristian LU (2020) In RNA Biology 17(8). p.1214-1222
Abstract

ABTRACT: tRNA-derived fragments or tRFs were long considered merely degradation intermediates of full-length tRNAs; however, emerging research is highlighting unanticipated new and highly distinct functions in epigenetic control, metabolism, immune activity and stem cell fate commitment. Importantly, recent studies suggest that RNA epitranscriptomic modifications may provide an additional regulatory layer that dynamically directs tRF activity in stem and cancer cells. In this review, we explore current work illustrating unanticipated roles of tRFs in mammalian stem cells with a focus on the impact of post-transcriptional RNA modifications for the biogenesis and function of this growing class of small noncoding RNAs.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
5-methylcytosine, development, hematopoiesis, pseudouridine, RNA epitranscriptomics, RNA modifications, stem cells, translation control, tRNA fragments
in
RNA Biology
volume
17
issue
8
pages
9 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85080932385
  • pmid:32116113
ISSN
1547-6286
DOI
10.1080/15476286.2020.1732694
language
English
LU publication?
yes
id
7b8ab872-c2f9-4fbf-a3bb-5206302b5d51
date added to LUP
2020-03-20 15:31:15
date last changed
2024-06-13 13:16:05
@article{7b8ab872-c2f9-4fbf-a3bb-5206302b5d51,
  abstract     = {{<p>ABTRACT: tRNA-derived fragments or tRFs were long considered merely degradation intermediates of full-length tRNAs; however, emerging research is highlighting unanticipated new and highly distinct functions in epigenetic control, metabolism, immune activity and stem cell fate commitment. Importantly, recent studies suggest that RNA epitranscriptomic modifications may provide an additional regulatory layer that dynamically directs tRF activity in stem and cancer cells. In this review, we explore current work illustrating unanticipated roles of tRFs in mammalian stem cells with a focus on the impact of post-transcriptional RNA modifications for the biogenesis and function of this growing class of small noncoding RNAs.</p>}},
  author       = {{Guzzi, Nicola and Bellodi, Cristian}},
  issn         = {{1547-6286}},
  keywords     = {{5-methylcytosine; development; hematopoiesis; pseudouridine; RNA epitranscriptomics; RNA modifications; stem cells; translation control; tRNA fragments}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{8}},
  pages        = {{1214--1222}},
  publisher    = {{Taylor & Francis}},
  series       = {{RNA Biology}},
  title        = {{Novel insights into the emerging roles of tRNA-derived fragments in mammalian development}},
  url          = {{http://dx.doi.org/10.1080/15476286.2020.1732694}},
  doi          = {{10.1080/15476286.2020.1732694}},
  volume       = {{17}},
  year         = {{2020}},
}