Novel insights into the emerging roles of tRNA-derived fragments in mammalian development
(2020) In RNA Biology 17(8). p.1214-1222- Abstract
ABTRACT: tRNA-derived fragments or tRFs were long considered merely degradation intermediates of full-length tRNAs; however, emerging research is highlighting unanticipated new and highly distinct functions in epigenetic control, metabolism, immune activity and stem cell fate commitment. Importantly, recent studies suggest that RNA epitranscriptomic modifications may provide an additional regulatory layer that dynamically directs tRF activity in stem and cancer cells. In this review, we explore current work illustrating unanticipated roles of tRFs in mammalian stem cells with a focus on the impact of post-transcriptional RNA modifications for the biogenesis and function of this growing class of small noncoding RNAs.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7b8ab872-c2f9-4fbf-a3bb-5206302b5d51
- author
- Guzzi, Nicola LU and Bellodi, Cristian LU
- organization
- publishing date
- 2020-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 5-methylcytosine, development, hematopoiesis, pseudouridine, RNA epitranscriptomics, RNA modifications, stem cells, translation control, tRNA fragments
- in
- RNA Biology
- volume
- 17
- issue
- 8
- pages
- 9 pages
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:85080932385
- pmid:32116113
- ISSN
- 1547-6286
- DOI
- 10.1080/15476286.2020.1732694
- language
- English
- LU publication?
- yes
- id
- 7b8ab872-c2f9-4fbf-a3bb-5206302b5d51
- date added to LUP
- 2020-03-20 15:31:15
- date last changed
- 2024-07-24 15:12:32
@article{7b8ab872-c2f9-4fbf-a3bb-5206302b5d51, abstract = {{<p>ABTRACT: tRNA-derived fragments or tRFs were long considered merely degradation intermediates of full-length tRNAs; however, emerging research is highlighting unanticipated new and highly distinct functions in epigenetic control, metabolism, immune activity and stem cell fate commitment. Importantly, recent studies suggest that RNA epitranscriptomic modifications may provide an additional regulatory layer that dynamically directs tRF activity in stem and cancer cells. In this review, we explore current work illustrating unanticipated roles of tRFs in mammalian stem cells with a focus on the impact of post-transcriptional RNA modifications for the biogenesis and function of this growing class of small noncoding RNAs.</p>}}, author = {{Guzzi, Nicola and Bellodi, Cristian}}, issn = {{1547-6286}}, keywords = {{5-methylcytosine; development; hematopoiesis; pseudouridine; RNA epitranscriptomics; RNA modifications; stem cells; translation control; tRNA fragments}}, language = {{eng}}, month = {{03}}, number = {{8}}, pages = {{1214--1222}}, publisher = {{Taylor & Francis}}, series = {{RNA Biology}}, title = {{Novel insights into the emerging roles of tRNA-derived fragments in mammalian development}}, url = {{http://dx.doi.org/10.1080/15476286.2020.1732694}}, doi = {{10.1080/15476286.2020.1732694}}, volume = {{17}}, year = {{2020}}, }