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Midnight salivary cortisol secretion associated with high systolic blood pressure in type 1 diabetes

Melin, Eva Olga LU ; Hillman, Magnus LU and Landin-Olsson, Mona LU (2019) In Endocrine Connections 8(11). p.1520-1528
Abstract

Objective: To explore associations between high midnight salivary cortisol (MSC) secretion and high blood pressure (BP) in type 1 diabetes (T1D). Methods: Cross-sectional study of 196 adult patients with T1D (54% men). Associations between high MSC (≥9.3 nmol/L) and high systolic BP (>130 mmHg), and high diastolic BP (>80 mmHg) were explored for all patients, users and non-users of antihypertensive drugs (AHD). Adjustments were performed for age, sex, diabetes-related variables, p-creatinine, smoking, physical inactivity, depression and medication. Results: The prevalence of high MSC differed between patients with high and low systolic BP in all 196 patients: 39 vs 13% (P = 0.001); in 60 users of AHD: 37 vs 12% (P = 0.039), and in... (More)

Objective: To explore associations between high midnight salivary cortisol (MSC) secretion and high blood pressure (BP) in type 1 diabetes (T1D). Methods: Cross-sectional study of 196 adult patients with T1D (54% men). Associations between high MSC (≥9.3 nmol/L) and high systolic BP (>130 mmHg), and high diastolic BP (>80 mmHg) were explored for all patients, users and non-users of antihypertensive drugs (AHD). Adjustments were performed for age, sex, diabetes-related variables, p-creatinine, smoking, physical inactivity, depression and medication. Results: The prevalence of high MSC differed between patients with high and low systolic BP in all 196 patients: 39 vs 13% (P = 0.001); in 60 users of AHD: 37 vs 12% (P = 0.039), and in 136 non-users of AHD: 43 vs 13% (P = 0.012). Significant associations with high systolic BP were for all patients: physical inactivity (adjusted odds ratio (AOR) 6.5), high MSC (AOR 3.9), abdominal obesity (AOR 3.7), AHD (AOR 2.9), age (per year) (AOR 1.07), and p-creatinine (per µmol/L) (AOR 1.03); for 60 users of AHD: high MSC (AOR 4.1) and age (per year) (AOR 1.11); for 136 non-users of AHD: abdominal obesity (AOR 27.4), physical inactivity (AOR 14.7), male sex (AOR 9.0), smoking (AOR 7.9), and age (per year) (AOR 1.08). High MSC was not associated with high DBP. Conclusions: In adult patients with T1D, high systolic BP was associated with physical inactivity, high MSC secretion, abdominal obesity, p-creatinine, age, and AHD, the latter indicating treatment failure.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antihypertensive drugs, Cortisol, Hypertension, Obesity, Physical inactivity, Sex differences, Smoking, Treatment failure, Type 1 diabetes
in
Endocrine Connections
volume
8
issue
11
pages
1520 - 1528
publisher
BioScientifica
external identifiers
  • scopus:85076344012
ISSN
2049-3614
DOI
10.1530/EC-19-0407
language
English
LU publication?
yes
additional info
Funding Information: This research was supported by the Research and Development Fund of Region Kronoberg, Växjö, Sweden, and by the Research Council of South Eastern Sweden (FORSS), Linköping, Sweden. The funding sources were not involved in the collection, analysis and interpretation of data, in the writing of the report, or in the decision to submit the article for publication. Funding Information: The authors are grateful to Anna Lindgren, PhD, Lund University, Centre of Mathematics, Lund, Sweden, for her statistical skills. They are also grateful to the specialist diabetes nurses and doctors who recruited the patients included in this study. Funding This research was supported by the Research and Development Fund of Region Kronoberg, V?xj?, Sweden, and by the Research Council of South Eastern Sweden (FORSS), Link?ping, Sweden. The funding sources were not involved in the collection, analysis and interpretation of data, in the writing of the report, or in the decision to submit the article for publication. Publisher Copyright: © 2019 The authors.
id
7bbcc4d9-98f4-45de-8d5e-96ddd4c20838
date added to LUP
2023-08-22 09:47:12
date last changed
2024-02-03 16:44:15
@article{7bbcc4d9-98f4-45de-8d5e-96ddd4c20838,
  abstract     = {{<p>Objective: To explore associations between high midnight salivary cortisol (MSC) secretion and high blood pressure (BP) in type 1 diabetes (T1D). Methods: Cross-sectional study of 196 adult patients with T1D (54% men). Associations between high MSC (≥9.3 nmol/L) and high systolic BP (&gt;130 mmHg), and high diastolic BP (&gt;80 mmHg) were explored for all patients, users and non-users of antihypertensive drugs (AHD). Adjustments were performed for age, sex, diabetes-related variables, p-creatinine, smoking, physical inactivity, depression and medication. Results: The prevalence of high MSC differed between patients with high and low systolic BP in all 196 patients: 39 vs 13% (P = 0.001); in 60 users of AHD: 37 vs 12% (P = 0.039), and in 136 non-users of AHD: 43 vs 13% (P = 0.012). Significant associations with high systolic BP were for all patients: physical inactivity (adjusted odds ratio (AOR) 6.5), high MSC (AOR 3.9), abdominal obesity (AOR 3.7), AHD (AOR 2.9), age (per year) (AOR 1.07), and p-creatinine (per µmol/L) (AOR 1.03); for 60 users of AHD: high MSC (AOR 4.1) and age (per year) (AOR 1.11); for 136 non-users of AHD: abdominal obesity (AOR 27.4), physical inactivity (AOR 14.7), male sex (AOR 9.0), smoking (AOR 7.9), and age (per year) (AOR 1.08). High MSC was not associated with high DBP. Conclusions: In adult patients with T1D, high systolic BP was associated with physical inactivity, high MSC secretion, abdominal obesity, p-creatinine, age, and AHD, the latter indicating treatment failure.</p>}},
  author       = {{Melin, Eva Olga and Hillman, Magnus and Landin-Olsson, Mona}},
  issn         = {{2049-3614}},
  keywords     = {{Antihypertensive drugs; Cortisol; Hypertension; Obesity; Physical inactivity; Sex differences; Smoking; Treatment failure; Type 1 diabetes}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1520--1528}},
  publisher    = {{BioScientifica}},
  series       = {{Endocrine Connections}},
  title        = {{Midnight salivary cortisol secretion associated with high systolic blood pressure in type 1 diabetes}},
  url          = {{http://dx.doi.org/10.1530/EC-19-0407}},
  doi          = {{10.1530/EC-19-0407}},
  volume       = {{8}},
  year         = {{2019}},
}