Advanced

Association of the haptoglobin phenotype (1-1) with falciparum malaria in Sudan

Elagib, A A; Kider, A O; Åkerström, B LU and Elbashir, M I (1998) In Transactions of the Royal Society of Tropical Medicine and Hygiene 92(3). p.11-309
Abstract

The haptoglobin phenotypes of Sudanese patients with complicated and uncomplicated falciparum malaria, and those of uninfected randomly selected individuals, were determined by electrophoresis of sera on polyacrylamide gels followed by benzidine staining of the gels. Among 273 malaria patients, the proportions with haptoglobin phenotypes (1-1), (2-1) and (2-2) were 60.8%, 29.7% and 9.5%, respectively, and in 72 cerebral malaria patients the proportions were 63.9%, 29.2%, and 6.9%. The distribution among 208 control individuals was 26.0%, 55.8% and 18.3%, respectively. The difference between patients and controls was highly significant (P < 0.001). The distribution of the different haptoglobin phenotypes among the randomly selected... (More)

The haptoglobin phenotypes of Sudanese patients with complicated and uncomplicated falciparum malaria, and those of uninfected randomly selected individuals, were determined by electrophoresis of sera on polyacrylamide gels followed by benzidine staining of the gels. Among 273 malaria patients, the proportions with haptoglobin phenotypes (1-1), (2-1) and (2-2) were 60.8%, 29.7% and 9.5%, respectively, and in 72 cerebral malaria patients the proportions were 63.9%, 29.2%, and 6.9%. The distribution among 208 control individuals was 26.0%, 55.8% and 18.3%, respectively. The difference between patients and controls was highly significant (P < 0.001). The distribution of the different haptoglobin phenotypes among the randomly selected group of 208 Sudanese individuals was comparable to that in many other populations. The results suggests that the haptoglobin phenotype (1-1) is associated with susceptibility to falciparum malaria and the development of severe complications; alternatively, the other phenotypes may confer resistance.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Animals, Biomarkers/analysis, Child, Child, Preschool, Electrophoresis, Polyacrylamide Gel/methods, Haptoglobins/analysis, Humans, Immunoblotting/methods, Malaria, Cerebral/blood, Parasitology/methods, Sudan
in
Transactions of the Royal Society of Tropical Medicine and Hygiene
volume
92
issue
3
pages
11 - 309
publisher
Elsevier
ISSN
0035-9203
DOI
10.1016/s0035-9203(98)91025-2
language
English
LU publication?
yes
id
7be7193a-6fc5-43a2-bca8-d772c93a25b7
date added to LUP
2019-05-22 10:12:53
date last changed
2019-09-25 10:27:36
@article{7be7193a-6fc5-43a2-bca8-d772c93a25b7,
  abstract     = {<p>The haptoglobin phenotypes of Sudanese patients with complicated and uncomplicated falciparum malaria, and those of uninfected randomly selected individuals, were determined by electrophoresis of sera on polyacrylamide gels followed by benzidine staining of the gels. Among 273 malaria patients, the proportions with haptoglobin phenotypes (1-1), (2-1) and (2-2) were 60.8%, 29.7% and 9.5%, respectively, and in 72 cerebral malaria patients the proportions were 63.9%, 29.2%, and 6.9%. The distribution among 208 control individuals was 26.0%, 55.8% and 18.3%, respectively. The difference between patients and controls was highly significant (P &lt; 0.001). The distribution of the different haptoglobin phenotypes among the randomly selected group of 208 Sudanese individuals was comparable to that in many other populations. The results suggests that the haptoglobin phenotype (1-1) is associated with susceptibility to falciparum malaria and the development of severe complications; alternatively, the other phenotypes may confer resistance.</p>},
  author       = {Elagib, A A and Kider, A O and Åkerström, B and Elbashir, M I},
  issn         = {0035-9203},
  keyword      = {Adult,Animals,Biomarkers/analysis,Child,Child, Preschool,Electrophoresis, Polyacrylamide Gel/methods,Haptoglobins/analysis,Humans,Immunoblotting/methods,Malaria, Cerebral/blood,Parasitology/methods,Sudan},
  language     = {eng},
  month        = {12},
  number       = {3},
  pages        = {11--309},
  publisher    = {Elsevier},
  series       = {Transactions of the Royal Society of Tropical Medicine and Hygiene},
  title        = {Association of the haptoglobin phenotype (1-1) with falciparum malaria in Sudan},
  url          = {http://dx.doi.org/10.1016/s0035-9203(98)91025-2},
  volume       = {92},
  year         = {1998},
}