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Survivin Inhibition by Piperine Sensitizes Glioblastoma Cancer Stem Cells and Leads to Better Drug Response

Warrier, Neerada Meenakshi ; Krishnan, Ramesh Kumar ; Prabhu, Vijendra ; Hariharapura, Raghu Chandrashekhar ; Agarwal, Prasoon LU orcid and Kumar, Praveen (2022) In International Journal of Molecular Sciences 23(14).
Abstract

Glioblastoma multiforme (GBM) cancer stem cells (GSCs) are one of the strongest contributing factors to treatment resistance in GBM. Identification of biomarkers capable of directly affecting these cells within the bulk tumor is a major challenge associated with the development of new targeting strategies. In this study, we focus on understanding the potential of the multifunctional extraordinaire survivin as a biomarker for GSCs. We analyzed the expression profiles of this gene using various publicly available datasets to understand its importance in stemness and other cancer processes. The findings from these studies were further validated using human GSCs isolated from a GBM cell line. In these GSCs, survivin was inhibited using the... (More)

Glioblastoma multiforme (GBM) cancer stem cells (GSCs) are one of the strongest contributing factors to treatment resistance in GBM. Identification of biomarkers capable of directly affecting these cells within the bulk tumor is a major challenge associated with the development of new targeting strategies. In this study, we focus on understanding the potential of the multifunctional extraordinaire survivin as a biomarker for GSCs. We analyzed the expression profiles of this gene using various publicly available datasets to understand its importance in stemness and other cancer processes. The findings from these studies were further validated using human GSCs isolated from a GBM cell line. In these GSCs, survivin was inhibited using the dietary phytochemical piperine (PIP) and the subsequent effects on stemness, cancer processes and Temozolomide were investigated. In silico analysis identified survivin to be one of the most significant differentially regulated gene in GSCs, in comparison to common stemness markers. Further validation studies on the isolated GSCs showed the importance of survivin in stemness, cancer progression and therapy resistance. Taken together, our study identifies survivin as a more consistent GSC marker and also suggests the possibility of using survivin inhibitors along with standard of care drugs for better therapeutic outcomes.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glioblastoma cancer stem cells, integrative analysis, piperine, survivin, temozolomide, therapeutic targeting
in
International Journal of Molecular Sciences
volume
23
issue
14
article number
7604
publisher
MDPI AG
external identifiers
  • pmid:35886952
  • scopus:85135100984
ISSN
1661-6596
DOI
10.3390/ijms23147604
language
English
LU publication?
yes
id
7bedf48d-38c0-4b19-91cf-7c1b3efafb24
date added to LUP
2022-10-06 10:22:25
date last changed
2024-04-18 14:42:23
@article{7bedf48d-38c0-4b19-91cf-7c1b3efafb24,
  abstract     = {{<p>Glioblastoma multiforme (GBM) cancer stem cells (GSCs) are one of the strongest contributing factors to treatment resistance in GBM. Identification of biomarkers capable of directly affecting these cells within the bulk tumor is a major challenge associated with the development of new targeting strategies. In this study, we focus on understanding the potential of the multifunctional extraordinaire survivin as a biomarker for GSCs. We analyzed the expression profiles of this gene using various publicly available datasets to understand its importance in stemness and other cancer processes. The findings from these studies were further validated using human GSCs isolated from a GBM cell line. In these GSCs, survivin was inhibited using the dietary phytochemical piperine (PIP) and the subsequent effects on stemness, cancer processes and Temozolomide were investigated. In silico analysis identified survivin to be one of the most significant differentially regulated gene in GSCs, in comparison to common stemness markers. Further validation studies on the isolated GSCs showed the importance of survivin in stemness, cancer progression and therapy resistance. Taken together, our study identifies survivin as a more consistent GSC marker and also suggests the possibility of using survivin inhibitors along with standard of care drugs for better therapeutic outcomes.</p>}},
  author       = {{Warrier, Neerada Meenakshi and Krishnan, Ramesh Kumar and Prabhu, Vijendra and Hariharapura, Raghu Chandrashekhar and Agarwal, Prasoon and Kumar, Praveen}},
  issn         = {{1661-6596}},
  keywords     = {{glioblastoma cancer stem cells; integrative analysis; piperine; survivin; temozolomide; therapeutic targeting}},
  language     = {{eng}},
  number       = {{14}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Survivin Inhibition by Piperine Sensitizes Glioblastoma Cancer Stem Cells and Leads to Better Drug Response}},
  url          = {{http://dx.doi.org/10.3390/ijms23147604}},
  doi          = {{10.3390/ijms23147604}},
  volume       = {{23}},
  year         = {{2022}},
}