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Is there an association between alcohol intake or smoking and small bowel adenocarcinoma? Results from a European multi-center case-control study

Kaerlev, L. ; Teglbjaerg, P. S. ; Sabroe, S. ; Kolstad, H. A. ; Ahrens, W. ; Eriksson, M. LU orcid ; Guenel, P. ; Hardell, L. ; Launoy, G. and Merler, E. , et al. (2000) In Cancer Causes and Control 11(9). p.791-797
Abstract

Objective: To discover whether tobacco smoking and intake of different types of alcoholic drinks are associated with small bowel adenocarcinoma (SBA). Methods: A population-based European multi-center case-control study was conducted from 1995 to 1997. Results: After a histological review using uniform diagnostic criteria, 47 (33%) of the 142 identified cases of SBA were excluded due to reclassification as either tumors of the papilla of Vater (n = 22), stromal tumors, or metastases; 95 cases were accepted for study. In all, 70 cases of SBA together with 2070 controls matched by age, sex, and region were interviewed. A high intake (more than 24 g alcohol per day) of beer or spirits was associated with SBA, an odds ratio (OR) of 3.5 and... (More)

Objective: To discover whether tobacco smoking and intake of different types of alcoholic drinks are associated with small bowel adenocarcinoma (SBA). Methods: A population-based European multi-center case-control study was conducted from 1995 to 1997. Results: After a histological review using uniform diagnostic criteria, 47 (33%) of the 142 identified cases of SBA were excluded due to reclassification as either tumors of the papilla of Vater (n = 22), stromal tumors, or metastases; 95 cases were accepted for study. In all, 70 cases of SBA together with 2070 controls matched by age, sex, and region were interviewed. A high intake (more than 24 g alcohol per day) of beer or spirits was associated with SBA, an odds ratio (OR) of 3.5 and 95% confidence intervals (CI) of 1.5-8.0 and 3.4 (95% CI 1.3-9.2), respectively). There was no association with wine intake or total alcohol intake. Tobacco smoking was probably unrelated to SBA. Conclusions: A high intake of beer or spirits seems to be a risk factor for SBA. Since this association was not seen for wine drinkers, protective components of wine may counterbalance a carcinogenic effect of alcohol on the small bowel. Alternatively, the result may be confounded by other factors, e.g. dietary factors.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adenocarcinoma, Alcohol, Epidemiology, Small intestine, Tobacco
in
Cancer Causes and Control
volume
11
issue
9
pages
791 - 797
publisher
Springer
external identifiers
  • scopus:0033789496
  • pmid:11075867
ISSN
0957-5243
DOI
10.1023/A:1008920502888
language
English
LU publication?
no
id
7bf2a92a-924f-4285-87e7-144ee1da9ce7
date added to LUP
2020-02-21 16:28:49
date last changed
2024-05-29 09:45:17
@article{7bf2a92a-924f-4285-87e7-144ee1da9ce7,
  abstract     = {{<p>Objective: To discover whether tobacco smoking and intake of different types of alcoholic drinks are associated with small bowel adenocarcinoma (SBA). Methods: A population-based European multi-center case-control study was conducted from 1995 to 1997. Results: After a histological review using uniform diagnostic criteria, 47 (33%) of the 142 identified cases of SBA were excluded due to reclassification as either tumors of the papilla of Vater (n = 22), stromal tumors, or metastases; 95 cases were accepted for study. In all, 70 cases of SBA together with 2070 controls matched by age, sex, and region were interviewed. A high intake (more than 24 g alcohol per day) of beer or spirits was associated with SBA, an odds ratio (OR) of 3.5 and 95% confidence intervals (CI) of 1.5-8.0 and 3.4 (95% CI 1.3-9.2), respectively). There was no association with wine intake or total alcohol intake. Tobacco smoking was probably unrelated to SBA. Conclusions: A high intake of beer or spirits seems to be a risk factor for SBA. Since this association was not seen for wine drinkers, protective components of wine may counterbalance a carcinogenic effect of alcohol on the small bowel. Alternatively, the result may be confounded by other factors, e.g. dietary factors.</p>}},
  author       = {{Kaerlev, L. and Teglbjaerg, P. S. and Sabroe, S. and Kolstad, H. A. and Ahrens, W. and Eriksson, M. and Guenel, P. and Hardell, L. and Launoy, G. and Merler, E. and Merletti, F. and Stang, A. and Olsen, J.}},
  issn         = {{0957-5243}},
  keywords     = {{Adenocarcinoma; Alcohol; Epidemiology; Small intestine; Tobacco}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{9}},
  pages        = {{791--797}},
  publisher    = {{Springer}},
  series       = {{Cancer Causes and Control}},
  title        = {{Is there an association between alcohol intake or smoking and small bowel adenocarcinoma? Results from a European multi-center case-control study}},
  url          = {{http://dx.doi.org/10.1023/A:1008920502888}},
  doi          = {{10.1023/A:1008920502888}},
  volume       = {{11}},
  year         = {{2000}},
}