Selective synthesis of 2-substituted pyridine N-oxides via directed ortho-metallation using Grignard reagents
Andersson, Hans ; Gustafsson, Magnus LU ; Olsson, Roger LU
and Almqvist, Fredrik
(2008)
In Tetrahedron Letters
49(48).
p.6901-6903
- Abstract
Addition of i-PrMgCl to pyridine N-oxides in THF at -78 °C generates selectively an ortho-metallated species, which can be trapped with various electrophiles to generate 2-substituted pyridine N-oxides. Furthermore, by applying a double metal-catalyzed cross-coupling, direct arylation of the pyridine N-oxides is achieved.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7bf47b1c-0112-4427-bfb4-852811b29ba3
- author
- Andersson, Hans
; Gustafsson, Magnus
LU
; Olsson, Roger
LU
and Almqvist, Fredrik
- publishing date
- 2008-11-24
- type
- Contribution to journal
- publication status
- published
- in
- Tetrahedron Letters
- volume
- 49
- issue
- 48
- pages
- 6901 - 6903
- publisher
- Elsevier
- external identifiers
-
- scopus:53549097051
- ISSN
- 0040-4039
- DOI
- 10.1016/j.tetlet.2008.09.104
- language
- English
- LU publication?
- no
- id
- 7bf47b1c-0112-4427-bfb4-852811b29ba3
- date added to LUP
- 2019-10-02 10:20:43
- date last changed
- 2022-02-16 00:20:15
@article{7bf47b1c-0112-4427-bfb4-852811b29ba3,
abstract = {{<p>Addition of i-PrMgCl to pyridine N-oxides in THF at -78 °C generates selectively an ortho-metallated species, which can be trapped with various electrophiles to generate 2-substituted pyridine N-oxides. Furthermore, by applying a double metal-catalyzed cross-coupling, direct arylation of the pyridine N-oxides is achieved.</p>}},
author = {{Andersson, Hans and Gustafsson, Magnus and Olsson, Roger and Almqvist, Fredrik}},
issn = {{0040-4039}},
language = {{eng}},
month = {{11}},
number = {{48}},
pages = {{6901--6903}},
publisher = {{Elsevier}},
series = {{Tetrahedron Letters}},
title = {{Selective synthesis of 2-substituted pyridine N-oxides via directed ortho-metallation using Grignard reagents}},
url = {{http://dx.doi.org/10.1016/j.tetlet.2008.09.104}},
doi = {{10.1016/j.tetlet.2008.09.104}},
volume = {{49}},
year = {{2008}},
}