Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome.
(2002) In Scandinavian Journal of Rheumatology 31(2). p.72-79- Abstract
- Objective: To evaluate the eYcacy of the essential omega-6 fatty acid Gammalinolenic acid (GLA) on fatigue associated with primary
Sjo¨ gren’s syndrome.
Methods: Ninety patients with primary Sjo¨ gren’s syndrome (with or without signs of autoimmunity) entered a 6-month double blind
placebo-controlled randomised trial with high dose GLA (extracted from Evening Primrose Oil ) or corn oil. The primary outcome
parameter was fatigue; secondary endpoints were eye dryness, mouth dryness, muscle and joint pain.
Results: No statistically signiŽ cant improvement was found in fatigue assessed by Visual Analogue Scale (VAS) or in the time needed for
sleeping/resting during a 24-hour period. No... (More) - Objective: To evaluate the eYcacy of the essential omega-6 fatty acid Gammalinolenic acid (GLA) on fatigue associated with primary
Sjo¨ gren’s syndrome.
Methods: Ninety patients with primary Sjo¨ gren’s syndrome (with or without signs of autoimmunity) entered a 6-month double blind
placebo-controlled randomised trial with high dose GLA (extracted from Evening Primrose Oil ) or corn oil. The primary outcome
parameter was fatigue; secondary endpoints were eye dryness, mouth dryness, muscle and joint pain.
Results: No statistically signiŽ cant improvement was found in fatigue assessed by Visual Analogue Scale (VAS) or in the time needed for
sleeping/resting during a 24-hour period. No diVerences were found between the treatment and placebo group. The same applies to the
secondary endpoints: no diVerences in VAS for eye and mouth dryness or pain, no signiŽ cant changes in Schirmer-1-test, van Bijsterveld
score, unstimulated whole sialometry (UWS), or use of artiŽ cial tears or analgesics. Only mild side eVects were observed.
Conclusion: According to our study results GLA (Evening Primrose oil ) treatment for fatigue in primary Sjo¨gren’s syndrome is ineVective. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/115120
- author
- Theander, Elke LU ; Horrobin, David F ; Jacobsson, Lennart LU and Manthorpe, Rolf LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Non-U.S. Gov't, Treatment Outcome, gamma-Linolenic Acid: administration & dosage, Fatigue: etiology, Fatty Acids, Aged, Dermatologic Agents, Double-Blind Method, Fatigue: drug therapy, gamma-Linolenic Acid: adverse effects, Essential, Female, Human, Male, Middle Age, Patient Compliance, Sjogren's Syndrome: complications, Sjogren's Syndrome: drug therapy, Support
- in
- Scandinavian Journal of Rheumatology
- volume
- 31
- issue
- 2
- pages
- 72 - 79
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000175867000004
- pmid:12109650
- scopus:0036094653
- ISSN
- 1502-7732
- DOI
- 10.1080/03009740252937577
- language
- English
- LU publication?
- yes
- id
- 7bf983e8-d155-44cf-bcb1-d1a1434da82d (old id 115120)
- date added to LUP
- 2016-04-01 11:42:59
- date last changed
- 2025-10-14 11:41:03
@article{7bf983e8-d155-44cf-bcb1-d1a1434da82d,
abstract = {{Objective: To evaluate the eYcacy of the essential omega-6 fatty acid Gammalinolenic acid (GLA) on fatigue associated with primary<br/><br>
Sjo¨ gren’s syndrome.<br/><br>
Methods: Ninety patients with primary Sjo¨ gren’s syndrome (with or without signs of autoimmunity) entered a 6-month double blind<br/><br>
placebo-controlled randomised trial with high dose GLA (extracted from Evening Primrose Oil ) or corn oil. The primary outcome<br/><br>
parameter was fatigue; secondary endpoints were eye dryness, mouth dryness, muscle and joint pain.<br/><br>
Results: No statistically signiŽ cant improvement was found in fatigue assessed by Visual Analogue Scale (VAS) or in the time needed for<br/><br>
sleeping/resting during a 24-hour period. No diVerences were found between the treatment and placebo group. The same applies to the<br/><br>
secondary endpoints: no diVerences in VAS for eye and mouth dryness or pain, no signiŽ cant changes in Schirmer-1-test, van Bijsterveld<br/><br>
score, unstimulated whole sialometry (UWS), or use of artiŽ cial tears or analgesics. Only mild side eVects were observed.<br/><br>
Conclusion: According to our study results GLA (Evening Primrose oil ) treatment for fatigue in primary Sjo¨gren’s syndrome is ineVective.}},
author = {{Theander, Elke and Horrobin, David F and Jacobsson, Lennart and Manthorpe, Rolf}},
issn = {{1502-7732}},
keywords = {{Non-U.S. Gov't; Treatment Outcome; gamma-Linolenic Acid: administration & dosage; Fatigue: etiology; Fatty Acids; Aged; Dermatologic Agents; Double-Blind Method; Fatigue: drug therapy; gamma-Linolenic Acid: adverse effects; Essential; Female; Human; Male; Middle Age; Patient Compliance; Sjogren's Syndrome: complications; Sjogren's Syndrome: drug therapy; Support}},
language = {{eng}},
number = {{2}},
pages = {{72--79}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Rheumatology}},
title = {{Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome.}},
url = {{http://dx.doi.org/10.1080/03009740252937577}},
doi = {{10.1080/03009740252937577}},
volume = {{31}},
year = {{2002}},
}