R5 HIV-1 with efficient DC-SIGN use is not selected for early after birth in vertically infected children.
(2013) In Journal of General Virology 94(Dec.,05). p.767-773- Abstract
- Binding of HIV to C-type lectin receptors may either result in enhanced trans-infection of T cells or virus degradation. We have investigated the efficacy of HIV-1 utilization of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN), a C-type lectin receptor, in the setting of intrauterine or intrapartum mother-to-child transmission. Viruses isolated from HIV-1 infected mothers, at delivery, and from their vertically infected children, early after birth and later in disease, were analysed for use of DC-SIGN, binding and ability to mediate trans-infection. DC-SIGN-use of the child's early virus tended to be reduced as compared with the corresponding maternal isolate. Furthermore, the children's late... (More)
- Binding of HIV to C-type lectin receptors may either result in enhanced trans-infection of T cells or virus degradation. We have investigated the efficacy of HIV-1 utilization of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN), a C-type lectin receptor, in the setting of intrauterine or intrapartum mother-to-child transmission. Viruses isolated from HIV-1 infected mothers, at delivery, and from their vertically infected children, early after birth and later in disease, were analysed for use of DC-SIGN, binding and ability to mediate trans-infection. DC-SIGN-use of the child's early virus tended to be reduced as compared with the corresponding maternal isolate. Furthermore, the children's late isolate displayed enhanced DC-SIGN utilization compared with the corresponding early virus. These results were also supported in head-to-head competition assays and suggest that HIV-1 variants displaying efficient DC-SIGN-use are not selected for during intrauterine or intrapartum mother-to-child transmission. However, viruses with increased DC-SIGN-use may evolve later in paediatric HIV-1 infections. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3347429
- author
- Borggren, Marie LU ; Navér, Lars ; Casper, Charlotte ; Ehrnst, Anneka and Jansson, Marianne LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of General Virology
- volume
- 94
- issue
- Dec.,05
- pages
- 767 - 773
- publisher
- Microbiology Society
- external identifiers
-
- wos:000317995200009
- pmid:23223619
- scopus:84875638044
- pmid:23223619
- ISSN
- 1465-2099
- DOI
- 10.1099/vir.0.043620-0
- language
- English
- LU publication?
- yes
- id
- 7c59fc4d-087f-4392-8b74-e1bdce2b95f3 (old id 3347429)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23223619?dopt=Abstract
- date added to LUP
- 2016-04-01 11:17:24
- date last changed
- 2022-02-18 01:34:07
@article{7c59fc4d-087f-4392-8b74-e1bdce2b95f3, abstract = {{Binding of HIV to C-type lectin receptors may either result in enhanced trans-infection of T cells or virus degradation. We have investigated the efficacy of HIV-1 utilization of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN), a C-type lectin receptor, in the setting of intrauterine or intrapartum mother-to-child transmission. Viruses isolated from HIV-1 infected mothers, at delivery, and from their vertically infected children, early after birth and later in disease, were analysed for use of DC-SIGN, binding and ability to mediate trans-infection. DC-SIGN-use of the child's early virus tended to be reduced as compared with the corresponding maternal isolate. Furthermore, the children's late isolate displayed enhanced DC-SIGN utilization compared with the corresponding early virus. These results were also supported in head-to-head competition assays and suggest that HIV-1 variants displaying efficient DC-SIGN-use are not selected for during intrauterine or intrapartum mother-to-child transmission. However, viruses with increased DC-SIGN-use may evolve later in paediatric HIV-1 infections.}}, author = {{Borggren, Marie and Navér, Lars and Casper, Charlotte and Ehrnst, Anneka and Jansson, Marianne}}, issn = {{1465-2099}}, language = {{eng}}, number = {{Dec.,05}}, pages = {{767--773}}, publisher = {{Microbiology Society}}, series = {{Journal of General Virology}}, title = {{R5 HIV-1 with efficient DC-SIGN use is not selected for early after birth in vertically infected children.}}, url = {{http://dx.doi.org/10.1099/vir.0.043620-0}}, doi = {{10.1099/vir.0.043620-0}}, volume = {{94}}, year = {{2013}}, }