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R5 HIV-1 with efficient DC-SIGN use is not selected for early after birth in vertically infected children.

Borggren, Marie LU ; Navér, Lars ; Casper, Charlotte ; Ehrnst, Anneka and Jansson, Marianne LU (2013) In Journal of General Virology 94(Dec.,05). p.767-773
Abstract
Binding of HIV to C-type lectin receptors may either result in enhanced trans-infection of T cells or virus degradation. We have investigated the efficacy of HIV-1 utilization of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN), a C-type lectin receptor, in the setting of intrauterine or intrapartum mother-to-child transmission. Viruses isolated from HIV-1 infected mothers, at delivery, and from their vertically infected children, early after birth and later in disease, were analysed for use of DC-SIGN, binding and ability to mediate trans-infection. DC-SIGN-use of the child's early virus tended to be reduced as compared with the corresponding maternal isolate. Furthermore, the children's late... (More)
Binding of HIV to C-type lectin receptors may either result in enhanced trans-infection of T cells or virus degradation. We have investigated the efficacy of HIV-1 utilization of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN), a C-type lectin receptor, in the setting of intrauterine or intrapartum mother-to-child transmission. Viruses isolated from HIV-1 infected mothers, at delivery, and from their vertically infected children, early after birth and later in disease, were analysed for use of DC-SIGN, binding and ability to mediate trans-infection. DC-SIGN-use of the child's early virus tended to be reduced as compared with the corresponding maternal isolate. Furthermore, the children's late isolate displayed enhanced DC-SIGN utilization compared with the corresponding early virus. These results were also supported in head-to-head competition assays and suggest that HIV-1 variants displaying efficient DC-SIGN-use are not selected for during intrauterine or intrapartum mother-to-child transmission. However, viruses with increased DC-SIGN-use may evolve later in paediatric HIV-1 infections. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of General Virology
volume
94
issue
Dec.,05
pages
767 - 773
publisher
Microbiology Society
external identifiers
  • wos:000317995200009
  • pmid:23223619
  • scopus:84875638044
  • pmid:23223619
ISSN
1465-2099
DOI
10.1099/vir.0.043620-0
language
English
LU publication?
yes
id
7c59fc4d-087f-4392-8b74-e1bdce2b95f3 (old id 3347429)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23223619?dopt=Abstract
date added to LUP
2016-04-01 11:17:24
date last changed
2022-02-18 01:34:07
@article{7c59fc4d-087f-4392-8b74-e1bdce2b95f3,
  abstract     = {{Binding of HIV to C-type lectin receptors may either result in enhanced trans-infection of T cells or virus degradation. We have investigated the efficacy of HIV-1 utilization of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN), a C-type lectin receptor, in the setting of intrauterine or intrapartum mother-to-child transmission. Viruses isolated from HIV-1 infected mothers, at delivery, and from their vertically infected children, early after birth and later in disease, were analysed for use of DC-SIGN, binding and ability to mediate trans-infection. DC-SIGN-use of the child's early virus tended to be reduced as compared with the corresponding maternal isolate. Furthermore, the children's late isolate displayed enhanced DC-SIGN utilization compared with the corresponding early virus. These results were also supported in head-to-head competition assays and suggest that HIV-1 variants displaying efficient DC-SIGN-use are not selected for during intrauterine or intrapartum mother-to-child transmission. However, viruses with increased DC-SIGN-use may evolve later in paediatric HIV-1 infections.}},
  author       = {{Borggren, Marie and Navér, Lars and Casper, Charlotte and Ehrnst, Anneka and Jansson, Marianne}},
  issn         = {{1465-2099}},
  language     = {{eng}},
  number       = {{Dec.,05}},
  pages        = {{767--773}},
  publisher    = {{Microbiology Society}},
  series       = {{Journal of General Virology}},
  title        = {{R5 HIV-1 with efficient DC-SIGN use is not selected for early after birth in vertically infected children.}},
  url          = {{http://dx.doi.org/10.1099/vir.0.043620-0}},
  doi          = {{10.1099/vir.0.043620-0}},
  volume       = {{94}},
  year         = {{2013}},
}