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Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection

Sternberg, J and McGuigan, F LU (1992) In European Journal of Immunology 22(10). p.4-2741
Abstract

African trypanosomes induce a generalized state of immunosuppression in their mammalian hosts. One characteristic of this is a suppression of lymphocyte responses to mitogen, which is mediated by suppressor macrophages. We investigated the involvement of nitric oxide in this phenomenon. Both peritoneal and splenic cell cultures from infected mice released nitrite and this was inhibitable by NG-monomethyl L-arginine (L-NMMA). The release of nitrite correlated with suppressed splenic T cell proliferative responses to concanavalin A. It was shown that adherent spleen cells from infected mice mediate suppression, which could be abrogated by L-NMMA. These results suggest that in T. brucei infection, the activation of macrophages to produce... (More)

African trypanosomes induce a generalized state of immunosuppression in their mammalian hosts. One characteristic of this is a suppression of lymphocyte responses to mitogen, which is mediated by suppressor macrophages. We investigated the involvement of nitric oxide in this phenomenon. Both peritoneal and splenic cell cultures from infected mice released nitrite and this was inhibitable by NG-monomethyl L-arginine (L-NMMA). The release of nitrite correlated with suppressed splenic T cell proliferative responses to concanavalin A. It was shown that adherent spleen cells from infected mice mediate suppression, which could be abrogated by L-NMMA. These results suggest that in T. brucei infection, the activation of macrophages to produce nitric oxide leads to impaired lymphocyte responses and immunosuppression.

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published
keywords
Animals, Arginine, Concanavalin A, Immune Tolerance, Lymphocyte Activation, Mice, Mice, Inbred C3H, Nitric Oxide, Nitrites, Spleen, T-Lymphocytes, Trypanosoma brucei brucei, Trypanosomiasis, African, omega-N-Methylarginine, Journal Article, Research Support, Non-U.S. Gov't
in
European Journal of Immunology
volume
22
issue
10
pages
4 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:0026788352
ISSN
0014-2980
DOI
10.1002/eji.1830221041
language
English
LU publication?
no
id
7c6049fd-eb80-4755-9963-45002131dc3e
date added to LUP
2018-01-02 11:07:24
date last changed
2018-11-21 21:36:56
@article{7c6049fd-eb80-4755-9963-45002131dc3e,
  abstract     = {<p>African trypanosomes induce a generalized state of immunosuppression in their mammalian hosts. One characteristic of this is a suppression of lymphocyte responses to mitogen, which is mediated by suppressor macrophages. We investigated the involvement of nitric oxide in this phenomenon. Both peritoneal and splenic cell cultures from infected mice released nitrite and this was inhibitable by NG-monomethyl L-arginine (L-NMMA). The release of nitrite correlated with suppressed splenic T cell proliferative responses to concanavalin A. It was shown that adherent spleen cells from infected mice mediate suppression, which could be abrogated by L-NMMA. These results suggest that in T. brucei infection, the activation of macrophages to produce nitric oxide leads to impaired lymphocyte responses and immunosuppression.</p>},
  author       = {Sternberg, J and McGuigan, F},
  issn         = {0014-2980},
  keyword      = {Animals,Arginine,Concanavalin A,Immune Tolerance,Lymphocyte Activation,Mice,Mice, Inbred C3H,Nitric Oxide,Nitrites,Spleen,T-Lymphocytes,Trypanosoma brucei brucei,Trypanosomiasis, African,omega-N-Methylarginine,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {10},
  pages        = {4--2741},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection},
  url          = {http://dx.doi.org/10.1002/eji.1830221041},
  volume       = {22},
  year         = {1992},
}