Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection
Sternberg, J and McGuigan, F LU
(1992)
In European Journal of Immunology
22(10).
p.4-2741
- Abstract
African trypanosomes induce a generalized state of immunosuppression in their mammalian hosts. One characteristic of this is a suppression of lymphocyte responses to mitogen, which is mediated by suppressor macrophages. We investigated the involvement of nitric oxide in this phenomenon. Both peritoneal and splenic cell cultures from infected mice released nitrite and this was inhibitable by NG-monomethyl L-arginine (L-NMMA). The release of nitrite correlated with suppressed splenic T cell proliferative responses to concanavalin A. It was shown that adherent spleen cells from infected mice mediate suppression, which could be abrogated by L-NMMA. These results suggest that in T. brucei infection, the activation of macrophages to produce... (More)
African trypanosomes induce a generalized state of immunosuppression in their mammalian hosts. One characteristic of this is a suppression of lymphocyte responses to mitogen, which is mediated by suppressor macrophages. We investigated the involvement of nitric oxide in this phenomenon. Both peritoneal and splenic cell cultures from infected mice released nitrite and this was inhibitable by NG-monomethyl L-arginine (L-NMMA). The release of nitrite correlated with suppressed splenic T cell proliferative responses to concanavalin A. It was shown that adherent spleen cells from infected mice mediate suppression, which could be abrogated by L-NMMA. These results suggest that in T. brucei infection, the activation of macrophages to produce nitric oxide leads to impaired lymphocyte responses and immunosuppression.
(Less)
- author
- Sternberg, J
and McGuigan, F
LU
- publishing date
- 1992-10
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Arginine, Concanavalin A, Immune Tolerance, Lymphocyte Activation, Mice, Mice, Inbred C3H, Nitric Oxide, Nitrites, Spleen, T-Lymphocytes, Trypanosoma brucei brucei, Trypanosomiasis, African, omega-N-Methylarginine, Journal Article, Research Support, Non-U.S. Gov't
- in
- European Journal of Immunology
- volume
- 22
- issue
- 10
- pages
- 4 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0026788352
- pmid:1396977
- ISSN
- 0014-2980
- DOI
- 10.1002/eji.1830221041
- language
- English
- LU publication?
- no
- id
- 7c6049fd-eb80-4755-9963-45002131dc3e
- date added to LUP
- 2018-01-02 11:07:24
- date last changed
- 2024-01-14 10:15:15
@article{7c6049fd-eb80-4755-9963-45002131dc3e,
abstract = {{<p>African trypanosomes induce a generalized state of immunosuppression in their mammalian hosts. One characteristic of this is a suppression of lymphocyte responses to mitogen, which is mediated by suppressor macrophages. We investigated the involvement of nitric oxide in this phenomenon. Both peritoneal and splenic cell cultures from infected mice released nitrite and this was inhibitable by NG-monomethyl L-arginine (L-NMMA). The release of nitrite correlated with suppressed splenic T cell proliferative responses to concanavalin A. It was shown that adherent spleen cells from infected mice mediate suppression, which could be abrogated by L-NMMA. These results suggest that in T. brucei infection, the activation of macrophages to produce nitric oxide leads to impaired lymphocyte responses and immunosuppression.</p>}},
author = {{Sternberg, J and McGuigan, F}},
issn = {{0014-2980}},
keywords = {{Animals; Arginine; Concanavalin A; Immune Tolerance; Lymphocyte Activation; Mice; Mice, Inbred C3H; Nitric Oxide; Nitrites; Spleen; T-Lymphocytes; Trypanosoma brucei brucei; Trypanosomiasis, African; omega-N-Methylarginine; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
number = {{10}},
pages = {{4--2741}},
publisher = {{John Wiley & Sons Inc.}},
series = {{European Journal of Immunology}},
title = {{Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection}},
url = {{http://dx.doi.org/10.1002/eji.1830221041}},
doi = {{10.1002/eji.1830221041}},
volume = {{22}},
year = {{1992}},
}