The prevalence of having coeliac disease in children with type 1 diabetes was not significantly higher during the Swedish coeliac epidemic
Bybrant, Mara Cerqueiro LU ; Palmkvist, Elsa LU
; Söderström, Hanna
LU
; Lindgren, Marie
LU
; Hildebrand, Hans
; Norström, Fredrik
and Carlsson, Annelie
LU
(2023)
In Acta Paediatrica, International Journal of Paediatrics
112(10).
p.2175-2181
- Abstract
Aim: From 1986 to 1996, there was a four-fold increase in coeliac disease among young Swedish children, known as the Swedish coeliac epidemic. Children with type 1 diabetes have an increased risk of developing coeliac disease. We studied whether the prevalence of coeliac disease differed in children with type 1 diabetes born during and after this epidemic. Methods: We compared national birth cohorts of 240 844 children born in 1992–1993 during the coeliac disease epidemic and 179 530 children born in 1997–1998 after the epidemic. Children diagnosed with both type 1 diabetes and coeliac disease were identified by merging information from five national registers. Results: There was no statistically significant difference in the prevalence... (More)
Aim: From 1986 to 1996, there was a four-fold increase in coeliac disease among young Swedish children, known as the Swedish coeliac epidemic. Children with type 1 diabetes have an increased risk of developing coeliac disease. We studied whether the prevalence of coeliac disease differed in children with type 1 diabetes born during and after this epidemic. Methods: We compared national birth cohorts of 240 844 children born in 1992–1993 during the coeliac disease epidemic and 179 530 children born in 1997–1998 after the epidemic. Children diagnosed with both type 1 diabetes and coeliac disease were identified by merging information from five national registers. Results: There was no statistically significant difference in the prevalence of coeliac disease among children with type 1 diabetes between the two cohorts: 176/1642 (10.7%, 95% confidence interval 9.2%–12.2%) in the cohort born during the coeliac disease epidemic versus 161/1380 (11.7%, 95% confidence interval 10.0%–13.5%) in the post-epidemic cohort. Conclusion: The prevalence of having both coeliac disease and type 1 diabetes was not significantly higher in children born during, than after, the Swedish coeliac epidemic. This may support a stronger genetic disposition in children who develop both conditions.
(Less)
- author
- Bybrant, Mara Cerqueiro
LU
; Palmkvist, Elsa
LU
; Söderström, Hanna
LU
; Lindgren, Marie
LU
; Hildebrand, Hans
; Norström, Fredrik
and Carlsson, Annelie
LU
- organization
- publishing date
- 2023-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- children and adolescents, coeliac disease12, epidemiology, register study, type 1 diabetes
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 112
- issue
- 10
- pages
- 7 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:37312596
- scopus:85164605811
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.16876
- language
- English
- LU publication?
- yes
- id
- 7c8e145d-f1e2-4eaf-8eb0-12b6da789056
- date added to LUP
- 2023-09-27 11:41:56
- date last changed
- 2024-04-19 01:44:23
@article{7c8e145d-f1e2-4eaf-8eb0-12b6da789056,
abstract = {{<p>Aim: From 1986 to 1996, there was a four-fold increase in coeliac disease among young Swedish children, known as the Swedish coeliac epidemic. Children with type 1 diabetes have an increased risk of developing coeliac disease. We studied whether the prevalence of coeliac disease differed in children with type 1 diabetes born during and after this epidemic. Methods: We compared national birth cohorts of 240 844 children born in 1992–1993 during the coeliac disease epidemic and 179 530 children born in 1997–1998 after the epidemic. Children diagnosed with both type 1 diabetes and coeliac disease were identified by merging information from five national registers. Results: There was no statistically significant difference in the prevalence of coeliac disease among children with type 1 diabetes between the two cohorts: 176/1642 (10.7%, 95% confidence interval 9.2%–12.2%) in the cohort born during the coeliac disease epidemic versus 161/1380 (11.7%, 95% confidence interval 10.0%–13.5%) in the post-epidemic cohort. Conclusion: The prevalence of having both coeliac disease and type 1 diabetes was not significantly higher in children born during, than after, the Swedish coeliac epidemic. This may support a stronger genetic disposition in children who develop both conditions.</p>}},
author = {{Bybrant, Mara Cerqueiro and Palmkvist, Elsa and Söderström, Hanna and Lindgren, Marie and Hildebrand, Hans and Norström, Fredrik and Carlsson, Annelie}},
issn = {{0803-5253}},
keywords = {{children and adolescents; coeliac disease12; epidemiology; register study; type 1 diabetes}},
language = {{eng}},
number = {{10}},
pages = {{2175--2181}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{The prevalence of having coeliac disease in children with type 1 diabetes was not significantly higher during the Swedish coeliac epidemic}},
url = {{http://dx.doi.org/10.1111/apa.16876}},
doi = {{10.1111/apa.16876}},
volume = {{112}},
year = {{2023}},
}