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Endocannabinoid System Biomarkers in Alzheimer's Disease

Ferreira, Pâmela C.L. ; Bellaver, Bruna ; Povala, Guilherme ; Brum, Wagner S. ; Tissot, Cécile ; Badji, Atef ; Sloan, Matthew E. ; Benedet, Andréa L. ; Rosa-Neto, Pedro and Ashton, Nicholas J. , et al. (2023) In Cannabis and Cannabinoid Research 8(1). p.77-91
Abstract

Background: Alterations in the endocannabinoid system (ES) have been described in Alzheimer's disease (AD) pathophysiology. In the past years, multiple ES biomarkers have been developed, promising to advance our understanding of ES changes in AD. Discussion: ES biomarkers, including positron emission tomography with cannabinoid receptors tracers and biofluid-based endocannabinoids, are associated with AD disease progression and pathological features. Conclusion: Although not specific enough for AD diagnosis, ES biomarkers hold promise for prognosis, drug-target engagement, and a better understanding of the disease. Here, we summarize currently available ES biomarker findings and discuss their potential applications in the AD research... (More)

Background: Alterations in the endocannabinoid system (ES) have been described in Alzheimer's disease (AD) pathophysiology. In the past years, multiple ES biomarkers have been developed, promising to advance our understanding of ES changes in AD. Discussion: ES biomarkers, including positron emission tomography with cannabinoid receptors tracers and biofluid-based endocannabinoids, are associated with AD disease progression and pathological features. Conclusion: Although not specific enough for AD diagnosis, ES biomarkers hold promise for prognosis, drug-target engagement, and a better understanding of the disease. Here, we summarize currently available ES biomarker findings and discuss their potential applications in the AD research field.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, biomarkers, dementia, endocannabinoid
in
Cannabis and Cannabinoid Research
volume
8
issue
1
pages
15 pages
publisher
Mary Ann Liebert, Inc.
external identifiers
  • scopus:85148737104
  • pmid:36394442
ISSN
2378-8763
DOI
10.1089/can.2022.0151
language
English
LU publication?
yes
id
7c95b1e3-6897-4008-ae82-951cfc650b65
date added to LUP
2023-03-16 10:32:32
date last changed
2024-02-17 19:59:02
@article{7c95b1e3-6897-4008-ae82-951cfc650b65,
  abstract     = {{<p>Background: Alterations in the endocannabinoid system (ES) have been described in Alzheimer's disease (AD) pathophysiology. In the past years, multiple ES biomarkers have been developed, promising to advance our understanding of ES changes in AD. Discussion: ES biomarkers, including positron emission tomography with cannabinoid receptors tracers and biofluid-based endocannabinoids, are associated with AD disease progression and pathological features. Conclusion: Although not specific enough for AD diagnosis, ES biomarkers hold promise for prognosis, drug-target engagement, and a better understanding of the disease. Here, we summarize currently available ES biomarker findings and discuss their potential applications in the AD research field.</p>}},
  author       = {{Ferreira, Pâmela C.L. and Bellaver, Bruna and Povala, Guilherme and Brum, Wagner S. and Tissot, Cécile and Badji, Atef and Sloan, Matthew E. and Benedet, Andréa L. and Rosa-Neto, Pedro and Ashton, Nicholas J. and Pascoal, Tharick A. and Leuzy, Antoine and Zimmer, Eduardo R.}},
  issn         = {{2378-8763}},
  keywords     = {{Alzheimer's disease; biomarkers; dementia; endocannabinoid}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{77--91}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{Cannabis and Cannabinoid Research}},
  title        = {{Endocannabinoid System Biomarkers in Alzheimer's Disease}},
  url          = {{http://dx.doi.org/10.1089/can.2022.0151}},
  doi          = {{10.1089/can.2022.0151}},
  volume       = {{8}},
  year         = {{2023}},
}