Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.
(2016) In Brain Behavior and Immunity 52(oct 26). p.153-160- Abstract
- Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has been proposed as a reliable approximation of NO synthetic capacity in vivo. The objectives of the present study were to test the hypotheses that (i) subjects with combat-related PTSD have lower GABR scores than combat controls, (ii) GABR score is inversely associated with the severity of psychopathological measures, (iii) GABR score is inversely... (More)
- Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has been proposed as a reliable approximation of NO synthetic capacity in vivo. The objectives of the present study were to test the hypotheses that (i) subjects with combat-related PTSD have lower GABR scores than combat controls, (ii) GABR score is inversely associated with the severity of psychopathological measures, (iii) GABR score is inversely associated with markers of inflammation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8147816
- author
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Brain Behavior and Immunity
- volume
- 52
- issue
- oct 26
- pages
- 153 - 160
- publisher
- Elsevier
- external identifiers
-
- pmid:26515034
- wos:000368317400018
- scopus:84953245769
- pmid:26515034
- ISSN
- 1090-2139
- DOI
- 10.1016/j.bbi.2015.10.015
- language
- English
- LU publication?
- yes
- id
- 7cc430f2-a8fe-4ed1-94f0-0b31976e43b3 (old id 8147816)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26515034?dopt=Abstract
- date added to LUP
- 2016-04-01 10:47:27
- date last changed
- 2022-04-28 01:23:25
@article{7cc430f2-a8fe-4ed1-94f0-0b31976e43b3, abstract = {{Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has been proposed as a reliable approximation of NO synthetic capacity in vivo. The objectives of the present study were to test the hypotheses that (i) subjects with combat-related PTSD have lower GABR scores than combat controls, (ii) GABR score is inversely associated with the severity of psychopathological measures, (iii) GABR score is inversely associated with markers of inflammation.}}, author = {{Bersani, Francesco Saverio and Wolkowitz, Owen M and Lindqvist, Daniel and Yehuda, Rachel and Flory, Janine and Bierer, Linda M and Makotine, Iouri and Abu-Amara, Duna and Coy, Michelle and Reus, Victor I and Epel, Elissa S and Marmar, Charles and Mellon, Synthia H}}, issn = {{1090-2139}}, language = {{eng}}, number = {{oct 26}}, pages = {{153--160}}, publisher = {{Elsevier}}, series = {{Brain Behavior and Immunity}}, title = {{Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.}}, url = {{http://dx.doi.org/10.1016/j.bbi.2015.10.015}}, doi = {{10.1016/j.bbi.2015.10.015}}, volume = {{52}}, year = {{2016}}, }