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CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis

Howlin, Jillian LU ; McBryan, J ; Napoletano, S ; Lambe, T ; McArdle, E ; Shioda, T and Martin, F (2006) In Oncogene 25(10). p.1532-1542
Abstract
Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed that homozygous null mutants exhibit retarded mammary ductal growth at puberty and, in addition, dilated ductal structures with a lack of spatial restriction of the subtending branches. Analysis of CITED1 homozygous null and heterozygous null mammary gland gene expression using microarrays suggested that the mammary-specific phenotype seen in the homozygous null females is due to a disturbance in the transcription of a number... (More)
Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed that homozygous null mutants exhibit retarded mammary ductal growth at puberty and, in addition, dilated ductal structures with a lack of spatial restriction of the subtending branches. Analysis of CITED1 homozygous null and heterozygous null mammary gland gene expression using microarrays suggested that the mammary-specific phenotype seen in the homozygous null females is due to a disturbance in the transcription of a number of key mediators of pubertal ductal morphogenesis. These include estrogen and TGFbeta responsive genes, such as the EGFR/ErbB2 ligand, amphiregulin, whose transcription we suggest is directly or indirectly regulated by CITED1. (Less)
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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Oncogene
volume
25
issue
10
pages
1532 - 1542
publisher
Nature Publishing Group
external identifiers
  • wos:000235890400010
  • scopus:33644844822
ISSN
1476-5594
DOI
10.1038/sj.onc.1209183
language
English
LU publication?
no
id
7ceaba1d-40c2-41ef-a402-e8bafeb85fdd (old id 1298313)
date added to LUP
2016-04-01 12:12:10
date last changed
2022-04-13 07:38:22
@article{7ceaba1d-40c2-41ef-a402-e8bafeb85fdd,
  abstract     = {{Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed that homozygous null mutants exhibit retarded mammary ductal growth at puberty and, in addition, dilated ductal structures with a lack of spatial restriction of the subtending branches. Analysis of CITED1 homozygous null and heterozygous null mammary gland gene expression using microarrays suggested that the mammary-specific phenotype seen in the homozygous null females is due to a disturbance in the transcription of a number of key mediators of pubertal ductal morphogenesis. These include estrogen and TGFbeta responsive genes, such as the EGFR/ErbB2 ligand, amphiregulin, whose transcription we suggest is directly or indirectly regulated by CITED1.}},
  author       = {{Howlin, Jillian and McBryan, J and Napoletano, S and Lambe, T and McArdle, E and Shioda, T and Martin, F}},
  issn         = {{1476-5594}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1532--1542}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Oncogene}},
  title        = {{CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis}},
  url          = {{http://dx.doi.org/10.1038/sj.onc.1209183}},
  doi          = {{10.1038/sj.onc.1209183}},
  volume       = {{25}},
  year         = {{2006}},
}