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Visual Evaluation of Ultrafast MRI in the Assessment of Residual Breast Cancer after Neoadjuvant Systemic Therapy : A Preliminary Study Association with Subtype

Honda, Maya ; Kataoka, Masako ; Iima, Mami ; Ota, Rie ; Ohashi, Akane LU ; Kishimoto, Ayami Ohno ; Miyake, Kanae Kawai ; Nickel, Marcel Dominik ; Yamada, Yosuke and Toi, Masakazu , et al. (2022) In Tomography 8(3). p.1522-1533
Abstract

The purpose of this study was to investigate the diagnostic performance of ultrafast DCE (UF-DCE) MRI after the completion of neoadjuvant systemic therapy (NST) in breast cancer. In this study, MR examinations of 55 post-NST breast cancers were retrospectively analyzed. Residual tumor sizes were measured in the 20th phase of UF-DCE MRI, early and delayed phases of conventional DCE MRI, and high spatial-resolution CE MRI (UF, early, delayed, and HR, respectively). The diagnostic performance for the detection of residual invasive cancer was calculated by ROC analysis. The size difference between MRI and pathological findings was analyzed using the Wilcoxon signed-rank test with the Bonferroni correction. The overall AUC was highest for UF... (More)

The purpose of this study was to investigate the diagnostic performance of ultrafast DCE (UF-DCE) MRI after the completion of neoadjuvant systemic therapy (NST) in breast cancer. In this study, MR examinations of 55 post-NST breast cancers were retrospectively analyzed. Residual tumor sizes were measured in the 20th phase of UF-DCE MRI, early and delayed phases of conventional DCE MRI, and high spatial-resolution CE MRI (UF, early, delayed, and HR, respectively). The diagnostic performance for the detection of residual invasive cancer was calculated by ROC analysis. The size difference between MRI and pathological findings was analyzed using the Wilcoxon signed-rank test with the Bonferroni correction. The overall AUC was highest for UF (0.86 and 0.88 for readers 1 and 2, respectively). The difference in imaging and pathological sizes for UF (5.7 ± 8.2 mm) was significantly smaller than those for early, delayed, and HR (p < 0.01). For luminal subtype breast cancer, the size difference was significantly smaller for UF and early than for delayed (p < 0.01). UF-DCE MRI demonstrated higher AUC and specificity for the more accurate detection of residual cancer and the visualization of tumor extent than conventional DCE MRI.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast neoplasm, magnetic resonance imaging, treatment
in
Tomography
volume
8
issue
3
pages
12 pages
publisher
Grapho Publications LLC
external identifiers
  • pmid:35736873
  • scopus:85132189081
ISSN
2379-1381
DOI
10.3390/tomography8030125
language
English
LU publication?
yes
id
7cfd4737-bd41-467c-ade6-77fe9c3541f0
date added to LUP
2022-09-30 13:32:54
date last changed
2024-04-14 12:59:21
@article{7cfd4737-bd41-467c-ade6-77fe9c3541f0,
  abstract     = {{<p>The purpose of this study was to investigate the diagnostic performance of ultrafast DCE (UF-DCE) MRI after the completion of neoadjuvant systemic therapy (NST) in breast cancer. In this study, MR examinations of 55 post-NST breast cancers were retrospectively analyzed. Residual tumor sizes were measured in the 20th phase of UF-DCE MRI, early and delayed phases of conventional DCE MRI, and high spatial-resolution CE MRI (UF, early, delayed, and HR, respectively). The diagnostic performance for the detection of residual invasive cancer was calculated by ROC analysis. The size difference between MRI and pathological findings was analyzed using the Wilcoxon signed-rank test with the Bonferroni correction. The overall AUC was highest for UF (0.86 and 0.88 for readers 1 and 2, respectively). The difference in imaging and pathological sizes for UF (5.7 ± 8.2 mm) was significantly smaller than those for early, delayed, and HR (p &lt; 0.01). For luminal subtype breast cancer, the size difference was significantly smaller for UF and early than for delayed (p &lt; 0.01). UF-DCE MRI demonstrated higher AUC and specificity for the more accurate detection of residual cancer and the visualization of tumor extent than conventional DCE MRI.</p>}},
  author       = {{Honda, Maya and Kataoka, Masako and Iima, Mami and Ota, Rie and Ohashi, Akane and Kishimoto, Ayami Ohno and Miyake, Kanae Kawai and Nickel, Marcel Dominik and Yamada, Yosuke and Toi, Masakazu and Nakamoto, Yuji}},
  issn         = {{2379-1381}},
  keywords     = {{breast neoplasm; magnetic resonance imaging; treatment}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1522--1533}},
  publisher    = {{Grapho Publications LLC}},
  series       = {{Tomography}},
  title        = {{Visual Evaluation of Ultrafast MRI in the Assessment of Residual Breast Cancer after Neoadjuvant Systemic Therapy : A Preliminary Study Association with Subtype}},
  url          = {{http://dx.doi.org/10.3390/tomography8030125}},
  doi          = {{10.3390/tomography8030125}},
  volume       = {{8}},
  year         = {{2022}},
}