Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Continuous downstream processing

Jungbauer, Alois ; Satzer, Peter ; Duerauer, Astrid ; Azevedo, Ana ; Aires-Barros, Raquel ; Nilsson, Bernt LU ; Farid, Suzy ; Goldrick, Stephen ; Ottens, Marcel and Sponchioni, Mattia , et al. (2024) In Separation and Purification Technology 338.
Abstract

The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity mandate a reduction in the environmental footprint of bioprocesses and production facilities. In the biopharmaceutical industry, two extreme production scenarios are applied: a fully disposable factory with the characteristics of full flexibility and speed, or a fixed large-scale plant with high capacity. Forward-looking solutions and ideas will be discussed how to combine new processes and environmental... (More)

The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity mandate a reduction in the environmental footprint of bioprocesses and production facilities. In the biopharmaceutical industry, two extreme production scenarios are applied: a fully disposable factory with the characteristics of full flexibility and speed, or a fixed large-scale plant with high capacity. Forward-looking solutions and ideas will be discussed how to combine new processes and environmental friendliness for the benefit of the patient, security of supply and profitability. The concept will be extended to large scale production of proteins for food and non-pharma applications, e.g., in material science and a roadmap towards a future plant will be laid out.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Continuous integrated biomanufacturing, Economics, Environmental footprint, Microfluidics, Scale down
in
Separation and Purification Technology
volume
338
article number
126439
publisher
Elsevier
external identifiers
  • scopus:85184072929
ISSN
1383-5866
DOI
10.1016/j.seppur.2024.126439
language
English
LU publication?
yes
id
7d23015b-9c11-455b-95f7-1f2ecc335056
date added to LUP
2024-02-26 14:35:34
date last changed
2024-02-29 13:03:48
@article{7d23015b-9c11-455b-95f7-1f2ecc335056,
  abstract     = {{<p>The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity mandate a reduction in the environmental footprint of bioprocesses and production facilities. In the biopharmaceutical industry, two extreme production scenarios are applied: a fully disposable factory with the characteristics of full flexibility and speed, or a fixed large-scale plant with high capacity. Forward-looking solutions and ideas will be discussed how to combine new processes and environmental friendliness for the benefit of the patient, security of supply and profitability. The concept will be extended to large scale production of proteins for food and non-pharma applications, e.g., in material science and a roadmap towards a future plant will be laid out.</p>}},
  author       = {{Jungbauer, Alois and Satzer, Peter and Duerauer, Astrid and Azevedo, Ana and Aires-Barros, Raquel and Nilsson, Bernt and Farid, Suzy and Goldrick, Stephen and Ottens, Marcel and Sponchioni, Mattia and Marcelo Fernandez Lahore, Hector}},
  issn         = {{1383-5866}},
  keywords     = {{Continuous integrated biomanufacturing; Economics; Environmental footprint; Microfluidics; Scale down}},
  language     = {{eng}},
  month        = {{06}},
  publisher    = {{Elsevier}},
  series       = {{Separation and Purification Technology}},
  title        = {{Continuous downstream processing}},
  url          = {{http://dx.doi.org/10.1016/j.seppur.2024.126439}},
  doi          = {{10.1016/j.seppur.2024.126439}},
  volume       = {{338}},
  year         = {{2024}},
}