Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Cytotoxic sesquiterpenes and diterpenes from the rhizomes of Curcuma zedoaroides Chaveer. & Tanee

Nguyen, Thi Thu ; Tran, Thi Hien LU ; Nguyen, Tuan Hoang and Do, Thi Ha (2024) In Biochemical Systematics and Ecology 112.
Abstract

A phytochemical investigation of Curcuma zedoaroides rhizomes resulted in the isolation of ten sesquiterpenes (1–10) and two diterpenes (11−12). The structure of compounds 1–12 was identified as phaeocaulisin E (1), zedoarondiol (2), isozedoarondiol (3), isoprocurcumenol (4), neoprocurcumenol (5), procurcumenol (6), 1-epi-procurcumenol (7), aerugidiol (8), curcumenol (9), curcumenone (10), curcuminol E (11), and zerumin A (12) using MS and NMR methods. Remarkably, all these compounds were found in C. zedoaroides for the first time and their chemotaxonomic significance was also discussed. Moreover, the fractionated extracts of C. zedoaroides (n-hexane, ethyl acetate, and water) were demonstrated to have effects on eight cancer cell lines... (More)

A phytochemical investigation of Curcuma zedoaroides rhizomes resulted in the isolation of ten sesquiterpenes (1–10) and two diterpenes (11−12). The structure of compounds 1–12 was identified as phaeocaulisin E (1), zedoarondiol (2), isozedoarondiol (3), isoprocurcumenol (4), neoprocurcumenol (5), procurcumenol (6), 1-epi-procurcumenol (7), aerugidiol (8), curcumenol (9), curcumenone (10), curcuminol E (11), and zerumin A (12) using MS and NMR methods. Remarkably, all these compounds were found in C. zedoaroides for the first time and their chemotaxonomic significance was also discussed. Moreover, the fractionated extracts of C. zedoaroides (n-hexane, ethyl acetate, and water) were demonstrated to have effects on eight cancer cell lines (A549, MCF-7, HT-29, MB49, HepG2, MDA-MB231, JB6-C141, and K562), exhibiting IC50 values ranging from 5.43 to 11.96 μg/mL. Compounds 1–9 and 11−12 displayed significant activity against five cancer cell lines (A549, MCF-7, MDA-MB231, HL-60, and HepG2), with IC50 values ranging from 3.13 μM to 30.10 μM. The most potent effect was observed in the A549 cell line (IC50: 3.13–13.54 μM).

(Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Curcuma zedoaroides, Cytotoxicity, Diterpenes, Sesquiterpenes, Zingiberaceae
in
Biochemical Systematics and Ecology
volume
112
article number
104781
publisher
Elsevier
external identifiers
  • scopus:85181744218
ISSN
0305-1978
DOI
10.1016/j.bse.2023.104781
language
English
LU publication?
yes
id
7d87af51-df32-40fb-a0aa-2d30bc56b1dc
date added to LUP
2024-02-13 11:53:03
date last changed
2024-02-19 11:24:08
@article{7d87af51-df32-40fb-a0aa-2d30bc56b1dc,
  abstract     = {{<p>A phytochemical investigation of Curcuma zedoaroides rhizomes resulted in the isolation of ten sesquiterpenes (1–10) and two diterpenes (11−12). The structure of compounds 1–12 was identified as phaeocaulisin E (1), zedoarondiol (2), isozedoarondiol (3), isoprocurcumenol (4), neoprocurcumenol (5), procurcumenol (6), 1-epi-procurcumenol (7), aerugidiol (8), curcumenol (9), curcumenone (10), curcuminol E (11), and zerumin A (12) using MS and NMR methods. Remarkably, all these compounds were found in C. zedoaroides for the first time and their chemotaxonomic significance was also discussed. Moreover, the fractionated extracts of C. zedoaroides (n-hexane, ethyl acetate, and water) were demonstrated to have effects on eight cancer cell lines (A549, MCF-7, HT-29, MB49, HepG2, MDA-MB231, JB6-C141, and K562), exhibiting IC<sub>50</sub> values ranging from 5.43 to 11.96 μg/mL. Compounds 1–9 and 11−12 displayed significant activity against five cancer cell lines (A549, MCF-7, MDA-MB231, HL-60, and HepG2), with IC<sub>50</sub> values ranging from 3.13 μM to 30.10 μM. The most potent effect was observed in the A549 cell line (IC<sub>50</sub>: 3.13–13.54 μM).</p>}},
  author       = {{Nguyen, Thi Thu and Tran, Thi Hien and Nguyen, Tuan Hoang and Do, Thi Ha}},
  issn         = {{0305-1978}},
  keywords     = {{Curcuma zedoaroides; Cytotoxicity; Diterpenes; Sesquiterpenes; Zingiberaceae}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Biochemical Systematics and Ecology}},
  title        = {{Cytotoxic sesquiterpenes and diterpenes from the rhizomes of Curcuma zedoaroides Chaveer. & Tanee}},
  url          = {{http://dx.doi.org/10.1016/j.bse.2023.104781}},
  doi          = {{10.1016/j.bse.2023.104781}},
  volume       = {{112}},
  year         = {{2024}},
}