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The role of dopaminergic immune cell signalling in poststroke inflammation

Talhada, Daniela LU ; Rabenstein, Monika and Ruscher, Karsten LU (2018) In Therapeutic Advances in Neurological Disorders 11.
Abstract

Upon ischaemic stroke, brain-resident and peripheral immune cells accumulate in the central nervous system (CNS). Interestingly, these cells express pattern specific to neurotransmitter receptors and, therefore, seem to be susceptible to neurotransmitter stimulation, potentially modulating their properties and functions. One of the principal neurotransmitters in the CNS, dopamine, is involved in the regulation of processes of brain development, motor control and higher brain functions. It is constantly released in the brain and there is experimental and clinical evidence that dopaminergic signalling is involved in recovery of lost neurological function after stroke. Independent studies have revealed specific but different patterns of... (More)

Upon ischaemic stroke, brain-resident and peripheral immune cells accumulate in the central nervous system (CNS). Interestingly, these cells express pattern specific to neurotransmitter receptors and, therefore, seem to be susceptible to neurotransmitter stimulation, potentially modulating their properties and functions. One of the principal neurotransmitters in the CNS, dopamine, is involved in the regulation of processes of brain development, motor control and higher brain functions. It is constantly released in the brain and there is experimental and clinical evidence that dopaminergic signalling is involved in recovery of lost neurological function after stroke. Independent studies have revealed specific but different patterns of dopamine receptor subtypes on different populations of immune cells. Those patterns are dependent on the activation status of cells. Generally, exposure to dopamine or dopamine receptor agonists decreases detrimental actions of immune cells. In contrast, a reduction of dopaminergic inputs perpetuates a pro-inflammatory state associated with increased release of pro-inflammatory molecules. In addition, subsets of immune cells have been identified to synthesize and release dopamine, suggesting autoregulatory mechanisms. Evidence supports that inflammatory processes activated following ischaemic stroke are modulated by dopaminergic signalling.

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publication status
published
subject
keywords
dopamine, dopamine receptor, immune cell, immunodepression, inflammation, neurotransmission, stroke recovery
in
Therapeutic Advances in Neurological Disorders
volume
11
publisher
SAGE Publications
external identifiers
  • scopus:85054850501
  • pmid:29774058
ISSN
1756-2856
DOI
10.1177/1756286418774225
language
English
LU publication?
yes
id
7d9a4a8a-2ab2-42c7-b9ac-4cb52f310964
date added to LUP
2018-11-09 08:47:42
date last changed
2021-10-06 05:48:25
@article{7d9a4a8a-2ab2-42c7-b9ac-4cb52f310964,
  abstract     = {<p>Upon ischaemic stroke, brain-resident and peripheral immune cells accumulate in the central nervous system (CNS). Interestingly, these cells express pattern specific to neurotransmitter receptors and, therefore, seem to be susceptible to neurotransmitter stimulation, potentially modulating their properties and functions. One of the principal neurotransmitters in the CNS, dopamine, is involved in the regulation of processes of brain development, motor control and higher brain functions. It is constantly released in the brain and there is experimental and clinical evidence that dopaminergic signalling is involved in recovery of lost neurological function after stroke. Independent studies have revealed specific but different patterns of dopamine receptor subtypes on different populations of immune cells. Those patterns are dependent on the activation status of cells. Generally, exposure to dopamine or dopamine receptor agonists decreases detrimental actions of immune cells. In contrast, a reduction of dopaminergic inputs perpetuates a pro-inflammatory state associated with increased release of pro-inflammatory molecules. In addition, subsets of immune cells have been identified to synthesize and release dopamine, suggesting autoregulatory mechanisms. Evidence supports that inflammatory processes activated following ischaemic stroke are modulated by dopaminergic signalling.</p>},
  author       = {Talhada, Daniela and Rabenstein, Monika and Ruscher, Karsten},
  issn         = {1756-2856},
  language     = {eng},
  month        = {05},
  publisher    = {SAGE Publications},
  series       = {Therapeutic Advances in Neurological Disorders},
  title        = {The role of dopaminergic immune cell signalling in poststroke inflammation},
  url          = {http://dx.doi.org/10.1177/1756286418774225},
  doi          = {10.1177/1756286418774225},
  volume       = {11},
  year         = {2018},
}