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Molecularly imprinted monodisperse microspheres for competitive radioassay

Ye, Lei LU orcid ; Cormack, Peter A.G. and Mosbach, Klaus LU (1999) In Analytical Communications 36(2). p.35-38
Abstract

In the present study, molecularly imprinted affinity sorbents against theophylline and 17β-estradiol are synthesised via precipitation polymerisation, a synthetic method that yields monodisperse, spherical polymer particles in the micronscale range, quickly, cleanly and in good yield. The specific binding sites that are created during the imprinting process are analysed via radioligand binding analysis. The molecularly imprinted microspheres are highly specific and have higher load capacities compared to the 'classical' particles obtained by grinding the imprinted monolith. The successful imprinting against model compounds with very different hydrophobicities demonstrates the generality of the current simple approach.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Communications
volume
36
issue
2
pages
4 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:0002791791
ISSN
1359-7337
DOI
10.1039/a809014i
language
English
LU publication?
yes
id
7da154d4-e5f2-47eb-bbb2-1b10f510494a
date added to LUP
2019-06-18 09:04:58
date last changed
2022-04-18 07:06:22
@article{7da154d4-e5f2-47eb-bbb2-1b10f510494a,
  abstract     = {{<p>In the present study, molecularly imprinted affinity sorbents against theophylline and 17β-estradiol are synthesised via precipitation polymerisation, a synthetic method that yields monodisperse, spherical polymer particles in the micronscale range, quickly, cleanly and in good yield. The specific binding sites that are created during the imprinting process are analysed via radioligand binding analysis. The molecularly imprinted microspheres are highly specific and have higher load capacities compared to the 'classical' particles obtained by grinding the imprinted monolith. The successful imprinting against model compounds with very different hydrophobicities demonstrates the generality of the current simple approach.</p>}},
  author       = {{Ye, Lei and Cormack, Peter A.G. and Mosbach, Klaus}},
  issn         = {{1359-7337}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{2}},
  pages        = {{35--38}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Analytical Communications}},
  title        = {{Molecularly imprinted monodisperse microspheres for competitive radioassay}},
  url          = {{http://dx.doi.org/10.1039/a809014i}},
  doi          = {{10.1039/a809014i}},
  volume       = {{36}},
  year         = {{1999}},
}