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Inhibitory effects of BCG on adenovirus tumorigenesis : Dependence on administration schedule

Ankerst, Jaro LU orcid and Jonsson, Nils LU (1972) In International Journal of Cancer 10(2). p.351-356
Abstract

The cumulative incidence of tumours was registered in CBA mice inoculated with adenovirus type 12 when newborn and treated with BCG in different ways during the latency period. A single subcutaneous dose of BCG at 3–4 weeks of age had a preventive effect, while no prevention could be recorded after a single BCG dose at 9 weeks of age or eight BCG injections at intervals of 1 week. Sera obtained during the latency period were tested for capacity to block lymph‐node cell‐mediated tumour immunity. Blocking activity was detectable in pooled serum of the mice which had been infected with BCG at 9 weeks of age, already at 10 weeks, i.e. 1 to 2 weeks before the appearance of palpable tumours. Blocking activity could not be demonstrated in a... (More)

The cumulative incidence of tumours was registered in CBA mice inoculated with adenovirus type 12 when newborn and treated with BCG in different ways during the latency period. A single subcutaneous dose of BCG at 3–4 weeks of age had a preventive effect, while no prevention could be recorded after a single BCG dose at 9 weeks of age or eight BCG injections at intervals of 1 week. Sera obtained during the latency period were tested for capacity to block lymph‐node cell‐mediated tumour immunity. Blocking activity was detectable in pooled serum of the mice which had been infected with BCG at 9 weeks of age, already at 10 weeks, i.e. 1 to 2 weeks before the appearance of palpable tumours. Blocking activity could not be demonstrated in a serum pool from control mice until 14 weeks after virus inoculation, at which time sera from mice inoculated with BCG at the age of 3 weeks were still negative. The results indicate that the effect of BCG upon tumour development is dependent upon the point of time of BCG treatment and further suggest that BCG treatment initiated at a stage when serum blocking activity is already present can further stimulate the production of blocking factors and tentatively promote tumour development.

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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
10
issue
2
pages
351 - 356
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:4661094
  • scopus:0015510458
ISSN
0020-7136
DOI
10.1002/ijc.2910100217
language
English
LU publication?
yes
id
7dcb36e0-1541-4c95-8b1a-9499cc44df8b
date added to LUP
2021-01-28 17:31:43
date last changed
2024-01-03 05:50:36
@article{7dcb36e0-1541-4c95-8b1a-9499cc44df8b,
  abstract     = {{<p>The cumulative incidence of tumours was registered in CBA mice inoculated with adenovirus type 12 when newborn and treated with BCG in different ways during the latency period. A single subcutaneous dose of BCG at 3–4 weeks of age had a preventive effect, while no prevention could be recorded after a single BCG dose at 9 weeks of age or eight BCG injections at intervals of 1 week. Sera obtained during the latency period were tested for capacity to block lymph‐node cell‐mediated tumour immunity. Blocking activity was detectable in pooled serum of the mice which had been infected with BCG at 9 weeks of age, already at 10 weeks, i.e. 1 to 2 weeks before the appearance of palpable tumours. Blocking activity could not be demonstrated in a serum pool from control mice until 14 weeks after virus inoculation, at which time sera from mice inoculated with BCG at the age of 3 weeks were still negative. The results indicate that the effect of BCG upon tumour development is dependent upon the point of time of BCG treatment and further suggest that BCG treatment initiated at a stage when serum blocking activity is already present can further stimulate the production of blocking factors and tentatively promote tumour development.</p>}},
  author       = {{Ankerst, Jaro and Jonsson, Nils}},
  issn         = {{0020-7136}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{351--356}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Inhibitory effects of BCG on adenovirus tumorigenesis : Dependence on administration schedule}},
  url          = {{http://dx.doi.org/10.1002/ijc.2910100217}},
  doi          = {{10.1002/ijc.2910100217}},
  volume       = {{10}},
  year         = {{1972}},
}