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An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves

Fornell, Anna LU ; Ohlin, Mathias; Garofalo, Fabio LU ; Nilsson, Johan LU and Tenje, Maria LU (2017) In Biomicrofluidics 11(3).
Abstract

To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped dropletsplitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomicrofluidics
volume
11
issue
3
publisher
American Institute of Physics
external identifiers
  • scopus:85019714138
  • wos:000404340600001
ISSN
1932-1058
DOI
10.1063/1.4984131
language
English
LU publication?
yes
id
7dcca38d-a787-4e23-bd5f-37040240eb1d
date added to LUP
2017-06-13 15:46:59
date last changed
2018-01-21 04:22:13
@article{7dcca38d-a787-4e23-bd5f-37040240eb1d,
  abstract     = {<p>To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped dropletsplitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.</p>},
  articleno    = {031101},
  author       = {Fornell, Anna and Ohlin, Mathias and Garofalo, Fabio and Nilsson, Johan and Tenje, Maria},
  issn         = {1932-1058},
  language     = {eng},
  month        = {05},
  number       = {3},
  publisher    = {American Institute of Physics},
  series       = {Biomicrofluidics},
  title        = {An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves},
  url          = {http://dx.doi.org/10.1063/1.4984131},
  volume       = {11},
  year         = {2017},
}