An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves
(2017) In Biomicrofluidics 11(3).- Abstract
To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped dropletsplitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7dcca38d-a787-4e23-bd5f-37040240eb1d
- author
- Fornell, Anna LU ; Ohlin, Mathias ; Garofalo, Fabio LU ; Nilsson, Johan LU and Tenje, Maria LU
- organization
- publishing date
- 2017-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biomicrofluidics
- volume
- 11
- issue
- 3
- article number
- 031101
- publisher
- American Institute of Physics (AIP)
- external identifiers
-
- pmid:28580044
- wos:000404340600001
- scopus:85019714138
- ISSN
- 1932-1058
- DOI
- 10.1063/1.4984131
- language
- English
- LU publication?
- yes
- id
- 7dcca38d-a787-4e23-bd5f-37040240eb1d
- date added to LUP
- 2017-06-13 15:46:59
- date last changed
- 2024-09-17 02:37:14
@article{7dcca38d-a787-4e23-bd5f-37040240eb1d, abstract = {{<p>To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped dropletsplitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.</p>}}, author = {{Fornell, Anna and Ohlin, Mathias and Garofalo, Fabio and Nilsson, Johan and Tenje, Maria}}, issn = {{1932-1058}}, language = {{eng}}, month = {{05}}, number = {{3}}, publisher = {{American Institute of Physics (AIP)}}, series = {{Biomicrofluidics}}, title = {{An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves}}, url = {{http://dx.doi.org/10.1063/1.4984131}}, doi = {{10.1063/1.4984131}}, volume = {{11}}, year = {{2017}}, }