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eGFR, cystatin C and creatinine in shrunken pore syndrome

Zhou, Hua; Yang, Min; He, Xiaozhou and Xu, Ning LU (2019) In Clinica Chimica Acta 498(Nov). p.1-5
Abstract

Shrunken pore syndrome (SPS) is a condition in which the estimated glomerular filtration rate (eGFR) based on serum/plasma cystatin C concentration is significantly lower than the eGFR based on creatinine. According to the literatures, the diagnosis of SPS could be defined when the eGFRcystatin C is <70% of eGFRcreatinine. Although the incidence of SPS varies in different patient populations and healthy seniors, it has been demonstrated that patients with SPS have poor prognosis. The present review has summarized its diagnosis, epidemiology, prognosis and possible pathophysiology basis. Moreover, we discuss the prevention and treatment of SPS in clinical practice as future challenges.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Creatinine, Cystatin C, Glomerular filtration rate, Shrunken pore syndrome
in
Clinica Chimica Acta
volume
498
issue
Nov
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:85070267771
ISSN
0009-8981
DOI
10.1016/j.cca.2019.08.001
language
English
LU publication?
yes
id
7dce4221-4712-484b-a04b-52a520e346bd
date added to LUP
2019-08-29 13:03:32
date last changed
2019-09-11 04:23:03
@article{7dce4221-4712-484b-a04b-52a520e346bd,
  abstract     = {<p>Shrunken pore syndrome (SPS) is a condition in which the estimated glomerular filtration rate (eGFR) based on serum/plasma cystatin C concentration is significantly lower than the eGFR based on creatinine. According to the literatures, the diagnosis of SPS could be defined when the eGFR<sub>cystatin C</sub> is &lt;70% of eGFR<sub>creatinine</sub>. Although the incidence of SPS varies in different patient populations and healthy seniors, it has been demonstrated that patients with SPS have poor prognosis. The present review has summarized its diagnosis, epidemiology, prognosis and possible pathophysiology basis. Moreover, we discuss the prevention and treatment of SPS in clinical practice as future challenges.</p>},
  author       = {Zhou, Hua and Yang, Min and He, Xiaozhou and Xu, Ning},
  issn         = {0009-8981},
  keyword      = {Creatinine,Cystatin C,Glomerular filtration rate,Shrunken pore syndrome},
  language     = {eng},
  number       = {Nov},
  pages        = {1--5},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {eGFR, cystatin C and creatinine in shrunken pore syndrome},
  url          = {http://dx.doi.org/10.1016/j.cca.2019.08.001},
  volume       = {498},
  year         = {2019},
}