Alpha-adrenoceptors and benign prostatic hyperplasia: basic principles for treatment with alpha-adrenoceptor antagonists.
Andersson, Karl-Erik LU
(2002)
In World Journal of Urology
19(6).
p.390-396
- Abstract
- The selective blockade of alpha1-adrenoceptors (ARs) is now a well-accepted and widely used treatment for patients presenting with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and bladder outlet obstruction. The sites of action of the currently used alpha1-AR antagonists when relieving LUTS have not yet been established, but it seems clear that effects on prostatic as well as non-prostatic tissues are important. Alpha1-ARs in the bladder, urethra, and vas deferens, on ganglia and nerve terminals, and in the central nervous system (CNS) may all influence LUTS and the clinical effects of alpha1-AR antagonists. The relevance of alpha1-AR subtype selectivity for the clinical usefulness of existing drug... (More)
- The selective blockade of alpha1-adrenoceptors (ARs) is now a well-accepted and widely used treatment for patients presenting with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and bladder outlet obstruction. The sites of action of the currently used alpha1-AR antagonists when relieving LUTS have not yet been established, but it seems clear that effects on prostatic as well as non-prostatic tissues are important. Alpha1-ARs in the bladder, urethra, and vas deferens, on ganglia and nerve terminals, and in the central nervous system (CNS) may all influence LUTS and the clinical effects of alpha1-AR antagonists. The relevance of alpha1-AR subtype selectivity for the clinical usefulness of existing drug therapy has still not been clarified, but it cannot be dismissed that blockading both alpha1A- and alpha1D-ARs is necessary for optimal clinical effect. Despite the above uncertainties, there seems to be a consensus that clinically available alpha1-AR antagonists provide a safe, effective and generally well-tolerated therapy for patients with LUTS. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/108363
- author
- Andersson, Karl-Erik
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- World Journal of Urology
- volume
- 19
- issue
- 6
- pages
- 390 - 396
- publisher
- Springer
- external identifiers
-
- wos:000175498900002
- pmid:12022707
- scopus:0036545439
- ISSN
- 1433-8726
- DOI
- 10.1007/s00345-001-0237-0
- language
- English
- LU publication?
- yes
- id
- 7ddceeb5-aef8-4f04-af84-4cfe09be6e26 (old id 108363)
- date added to LUP
- 2016-04-01 15:42:38
- date last changed
- 2022-01-28 06:43:55
@article{7ddceeb5-aef8-4f04-af84-4cfe09be6e26,
abstract = {{The selective blockade of alpha1-adrenoceptors (ARs) is now a well-accepted and widely used treatment for patients presenting with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and bladder outlet obstruction. The sites of action of the currently used alpha1-AR antagonists when relieving LUTS have not yet been established, but it seems clear that effects on prostatic as well as non-prostatic tissues are important. Alpha1-ARs in the bladder, urethra, and vas deferens, on ganglia and nerve terminals, and in the central nervous system (CNS) may all influence LUTS and the clinical effects of alpha1-AR antagonists. The relevance of alpha1-AR subtype selectivity for the clinical usefulness of existing drug therapy has still not been clarified, but it cannot be dismissed that blockading both alpha1A- and alpha1D-ARs is necessary for optimal clinical effect. Despite the above uncertainties, there seems to be a consensus that clinically available alpha1-AR antagonists provide a safe, effective and generally well-tolerated therapy for patients with LUTS.}},
author = {{Andersson, Karl-Erik}},
issn = {{1433-8726}},
language = {{eng}},
number = {{6}},
pages = {{390--396}},
publisher = {{Springer}},
series = {{World Journal of Urology}},
title = {{Alpha-adrenoceptors and benign prostatic hyperplasia: basic principles for treatment with alpha-adrenoceptor antagonists.}},
url = {{http://dx.doi.org/10.1007/s00345-001-0237-0}},
doi = {{10.1007/s00345-001-0237-0}},
volume = {{19}},
year = {{2002}},
}