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TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells

Brattås, Per Ludvik LU ; Jönsson, Marie E. LU ; Fasching, Liana LU ; Nelander Wahlestedt, Jenny LU orcid ; Shahsavani, Mansoureh ; Falk, Ronny ; Falk, Anna Helena LU orcid ; Jern, Patric ; Parmar, Malin LU orcid and Jakobsson, Johan LU orcid (2017) In Cell Reports 18(1). p.1-11
Abstract

Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of... (More)

Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epigenetics, gene regulation, human development, neural stem cells, transposable elements
in
Cell Reports
volume
18
issue
1
pages
11 pages
publisher
Cell Press
external identifiers
  • pmid:28052240
  • wos:000396465300001
  • scopus:85009112234
ISSN
2211-1247
DOI
10.1016/j.celrep.2016.12.010
language
English
LU publication?
yes
id
7dfdf7ef-b5b6-4f47-8690-eb1aa2f46ed6
date added to LUP
2017-03-03 08:27:05
date last changed
2025-01-07 08:59:39
@article{7dfdf7ef-b5b6-4f47-8690-eb1aa2f46ed6,
  abstract     = {{<p>Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.</p>}},
  author       = {{Brattås, Per Ludvik and Jönsson, Marie E. and Fasching, Liana and Nelander Wahlestedt, Jenny and Shahsavani, Mansoureh and Falk, Ronny and Falk, Anna Helena and Jern, Patric and Parmar, Malin and Jakobsson, Johan}},
  issn         = {{2211-1247}},
  keywords     = {{epigenetics; gene regulation; human development; neural stem cells; transposable elements}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{1--11}},
  publisher    = {{Cell Press}},
  series       = {{Cell Reports}},
  title        = {{TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells}},
  url          = {{http://dx.doi.org/10.1016/j.celrep.2016.12.010}},
  doi          = {{10.1016/j.celrep.2016.12.010}},
  volume       = {{18}},
  year         = {{2017}},
}