Artery blood pressure oscillation after active standing up: an indicator of sympathetic function in diabetic patients
Lindqvist, A ; Torffvit, Ole LU ; Rittner, Ralf LU
; Agardh, Carl-David
LU
and Pahlm, Olle
LU
(1997)
In Clinical Physiology
17(2).
p.159-169
- Abstract
- Dynamic artery blood pressure (Finapres) response to active standing up, normally consisting of initial rise, fall and recovery above the baseline (overshoot), was compared with the early steady-state artery blood pressure level to measure sympathetic vasomotor function in healthy subjects (n = 23, age 35 +/- 9 years; mean +/-SD) and in type I diabetic patients without autonomic neuropathy (AN) (group 1: n = 18, 38 +/- 13 years), with AN but no cardiovascular drugs (group 2a: n = 7, 44 +/- 11 years) and with both AN and cardiovascular drugs (group 2b: n = 10, 47 +/- 7 years). Systolic and diastolic overshoot were similar in the control (15 +/- 13/15 +/- 11 mmHg) and group 1 subjects. Systolic overshoot disappeared in 57% of patients in... (More)
- Dynamic artery blood pressure (Finapres) response to active standing up, normally consisting of initial rise, fall and recovery above the baseline (overshoot), was compared with the early steady-state artery blood pressure level to measure sympathetic vasomotor function in healthy subjects (n = 23, age 35 +/- 9 years; mean +/-SD) and in type I diabetic patients without autonomic neuropathy (AN) (group 1: n = 18, 38 +/- 13 years), with AN but no cardiovascular drugs (group 2a: n = 7, 44 +/- 11 years) and with both AN and cardiovascular drugs (group 2b: n = 10, 47 +/- 7 years). Systolic and diastolic overshoot were similar in the control (15 +/- 13/15 +/- 11 mmHg) and group 1 subjects. Systolic overshoot disappeared in 57% of patients in group 2a (-1 +/- 9 mmHg; P < 0.03), whereas artery blood pressure still overshot in diastole (8 +/- 7 mmHg; NS). Systolic overshoot disappeared in all patients in group 2b (-22 +/- 22 mmHg; P < 0.0006) and diastolic overshoot disappeared in 60% of these patients (-6 +/- 16 mmHg; P = 0.0006). Systolic early steady-state level was not lower in group 2a than in group 1 (NS), but it was impaired in group 2b (P < 0.006), in which six diabetic patients had a pathological response beyond the age-related reference values. There was a strong association between the overshoot and steady-state levels (P for chi 2 < 0.001, n = 58). Overshoot of the control subjects and patients in group 2b correlated to their respective steady-state blood pressure levels (r > or = 0.76; P < or = 0.001). In conclusion, baroreceptor reflex-dependent overshoot of the artery blood pressure after active standing up diminishes with the development of AN and it is associated with the early steady-state level of the artery blood pressure. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111713
- author
- Lindqvist, A
; Torffvit, Ole
LU
; Rittner, Ralf
LU
; Agardh, Carl-David
LU
and Pahlm, Olle
LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- artery blood pressure, asympathicotonic response, autonomic neuropathy, diabetes mellitus, baroreflex, blood pressure overshoot, Finapres, orthostatic test
- in
- Clinical Physiology
- volume
- 17
- issue
- 2
- pages
- 159 - 169
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:9156962
- scopus:0030993862
- ISSN
- 1365-2281
- DOI
- 10.1046/j.1365-2281.1997.02222.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510), Department of Clinical Physiology (Lund) (013013000), Division of Occupational and Environmental Medicine (013078001), Medicine (Lund) (013230025)
- id
- 7e0c647e-9deb-4fdc-80b4-51b6ae813f06 (old id 1111713)
- date added to LUP
- 2016-04-01 11:55:15
- date last changed
- 2024-01-08 01:31:16
@article{7e0c647e-9deb-4fdc-80b4-51b6ae813f06,
abstract = {{Dynamic artery blood pressure (Finapres) response to active standing up, normally consisting of initial rise, fall and recovery above the baseline (overshoot), was compared with the early steady-state artery blood pressure level to measure sympathetic vasomotor function in healthy subjects (n = 23, age 35 +/- 9 years; mean +/-SD) and in type I diabetic patients without autonomic neuropathy (AN) (group 1: n = 18, 38 +/- 13 years), with AN but no cardiovascular drugs (group 2a: n = 7, 44 +/- 11 years) and with both AN and cardiovascular drugs (group 2b: n = 10, 47 +/- 7 years). Systolic and diastolic overshoot were similar in the control (15 +/- 13/15 +/- 11 mmHg) and group 1 subjects. Systolic overshoot disappeared in 57% of patients in group 2a (-1 +/- 9 mmHg; P < 0.03), whereas artery blood pressure still overshot in diastole (8 +/- 7 mmHg; NS). Systolic overshoot disappeared in all patients in group 2b (-22 +/- 22 mmHg; P < 0.0006) and diastolic overshoot disappeared in 60% of these patients (-6 +/- 16 mmHg; P = 0.0006). Systolic early steady-state level was not lower in group 2a than in group 1 (NS), but it was impaired in group 2b (P < 0.006), in which six diabetic patients had a pathological response beyond the age-related reference values. There was a strong association between the overshoot and steady-state levels (P for chi 2 < 0.001, n = 58). Overshoot of the control subjects and patients in group 2b correlated to their respective steady-state blood pressure levels (r > or = 0.76; P < or = 0.001). In conclusion, baroreceptor reflex-dependent overshoot of the artery blood pressure after active standing up diminishes with the development of AN and it is associated with the early steady-state level of the artery blood pressure.}},
author = {{Lindqvist, A and Torffvit, Ole and Rittner, Ralf and Agardh, Carl-David and Pahlm, Olle}},
issn = {{1365-2281}},
keywords = {{artery blood pressure; asympathicotonic response; autonomic neuropathy; diabetes mellitus; baroreflex; blood pressure overshoot; Finapres; orthostatic test}},
language = {{eng}},
number = {{2}},
pages = {{159--169}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Clinical Physiology}},
title = {{Artery blood pressure oscillation after active standing up: an indicator of sympathetic function in diabetic patients}},
url = {{http://dx.doi.org/10.1046/j.1365-2281.1997.02222.x}},
doi = {{10.1046/j.1365-2281.1997.02222.x}},
volume = {{17}},
year = {{1997}},
}