Microalbuminuria and retinopathy in adolescents and young adults with type 1 and type 2 diabetes
Ek, Anna E. ; Samuelsson, Ulf ; Janson, Annika ; Carlsson, Annelie LU
; Elimam, Amira
and Marcus, Claude
(2020)
In Pediatric Diabetes
21(7).
p.1310-1321
- Abstract
Aim: To estimate the occurrence of complications related to early-onset type 2 diabetes compared with type 1 diabetes. Methods: All individuals registered in the Swedish Pediatric Quality Diabetes Register and the Swedish National Diabetes Register with type 2 diabetes diagnosis at 10 to 25 years of age between 1996 and 2014 (n = 1413) were included. As controls, individuals with type 1 diabetes were randomly selected from the same registers and were matched for age, sex, and year-of-onset (n = 3748). Results: Of the adolescents with type 2 diabetes in the pediatric register, 7.7% had microalbuminuria and 24.6% had signs of retinopathy 5 years after diagnosis, whereas the adolescents with type 1 diabetes 3.8% had microalbuminuria and... (More)
Aim: To estimate the occurrence of complications related to early-onset type 2 diabetes compared with type 1 diabetes. Methods: All individuals registered in the Swedish Pediatric Quality Diabetes Register and the Swedish National Diabetes Register with type 2 diabetes diagnosis at 10 to 25 years of age between 1996 and 2014 (n = 1413) were included. As controls, individuals with type 1 diabetes were randomly selected from the same registers and were matched for age, sex, and year-of-onset (n = 3748). Results: Of the adolescents with type 2 diabetes in the pediatric register, 7.7% had microalbuminuria and 24.6% had signs of retinopathy 5 years after diagnosis, whereas the adolescents with type 1 diabetes 3.8% had microalbuminuria and 19.2% had retinopathy. Among the young adults with type 2 diabetes from the adult diabetes register 10 years after diagnosis 15.2% had microalbuminuria and 39.7% retinopathy, whereas the young adults with type 1 diabetes 4.8% had microalbuminuria and 43.8% retinopathy. After adjustment for established risk factors measured over time in the whole combined cohort, individuals with type 2 diabetes had significantly higher risk of microalbuminuria with a hazard ratio (HR) of 3.32 (95% confidence interval, CI 2.86-3.85, P <.001), and retinopathy with a HR of 1.17 (95% CI 1.06-1.30, P 0.04). Conclusions: The prevalence of complications and comorbidities was higher among those with type 2 diabetes compared with type 1 diabetes, although prevalent in both groups. Early monitoring and more active treatment of type 2 diabetes in young individuals is required.
(Less)
- author
- Ek, Anna E.
; Samuelsson, Ulf
; Janson, Annika
; Carlsson, Annelie
LU
; Elimam, Amira
and Marcus, Claude
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adolescents, microalbuminuria, retinopathy, type 2 diabetes
- in
- Pediatric Diabetes
- volume
- 21
- issue
- 7
- pages
- 12 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:32613727
- scopus:85088704738
- ISSN
- 1399-543X
- DOI
- 10.1111/pedi.13074
- language
- English
- LU publication?
- yes
- id
- 7e6387b8-1beb-4562-918a-7f5b6fc5540e
- date added to LUP
- 2021-01-07 14:54:35
- date last changed
- 2024-05-16 01:06:54
@article{7e6387b8-1beb-4562-918a-7f5b6fc5540e,
abstract = {{<p>Aim: To estimate the occurrence of complications related to early-onset type 2 diabetes compared with type 1 diabetes. Methods: All individuals registered in the Swedish Pediatric Quality Diabetes Register and the Swedish National Diabetes Register with type 2 diabetes diagnosis at 10 to 25 years of age between 1996 and 2014 (n = 1413) were included. As controls, individuals with type 1 diabetes were randomly selected from the same registers and were matched for age, sex, and year-of-onset (n = 3748). Results: Of the adolescents with type 2 diabetes in the pediatric register, 7.7% had microalbuminuria and 24.6% had signs of retinopathy 5 years after diagnosis, whereas the adolescents with type 1 diabetes 3.8% had microalbuminuria and 19.2% had retinopathy. Among the young adults with type 2 diabetes from the adult diabetes register 10 years after diagnosis 15.2% had microalbuminuria and 39.7% retinopathy, whereas the young adults with type 1 diabetes 4.8% had microalbuminuria and 43.8% retinopathy. After adjustment for established risk factors measured over time in the whole combined cohort, individuals with type 2 diabetes had significantly higher risk of microalbuminuria with a hazard ratio (HR) of 3.32 (95% confidence interval, CI 2.86-3.85, P <.001), and retinopathy with a HR of 1.17 (95% CI 1.06-1.30, P 0.04). Conclusions: The prevalence of complications and comorbidities was higher among those with type 2 diabetes compared with type 1 diabetes, although prevalent in both groups. Early monitoring and more active treatment of type 2 diabetes in young individuals is required.</p>}},
author = {{Ek, Anna E. and Samuelsson, Ulf and Janson, Annika and Carlsson, Annelie and Elimam, Amira and Marcus, Claude}},
issn = {{1399-543X}},
keywords = {{adolescents; microalbuminuria; retinopathy; type 2 diabetes}},
language = {{eng}},
number = {{7}},
pages = {{1310--1321}},
publisher = {{Wiley-Blackwell}},
series = {{Pediatric Diabetes}},
title = {{Microalbuminuria and retinopathy in adolescents and young adults with type 1 and type 2 diabetes}},
url = {{http://dx.doi.org/10.1111/pedi.13074}},
doi = {{10.1111/pedi.13074}},
volume = {{21}},
year = {{2020}},
}