CARDIS (Cardiac ARrest DIgital Support) : study protocol for a randomised controlled trial of a web-based support intervention for cardiac arrest survivors
Waldemar, Annette ; Israelsson, Johan ; Heimburg, Katarina LU
; Blennow Nordström, Erik
LU
; Nordberg, Per
; Bremer, Anders
; Årestedt, Kristofer
and Thylén, Ingela
(2026)
In Resuscitation Plus
28.
p.1-11
- Abstract
Background: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported outcome measures of a co-created, web-based support programme designed to improve wellbeing, self management, and reintegration into everyday life for cardiac arrest survivors.
Methods: CARDIS is a multicentre, parallel-group, randomised controlled trial enrolling cardiac arrest survivors aged >18 years. Participants will be randomised... (More)
Background: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported outcome measures of a co-created, web-based support programme designed to improve wellbeing, self management, and reintegration into everyday life for cardiac arrest survivors.
Methods: CARDIS is a multicentre, parallel-group, randomised controlled trial enrolling cardiac arrest survivors aged >18 years. Participants will be randomised 1:1 to intervention or control. Both groups will receive standard post-cardiac arrest care, including a routine followup visit with screening and management of cognitive, physical and emotional health, as well as a printed booklet. The intervention group will additionally receive access to a webbased selfguided support programme for 3 months. After study completion, control participants will be offered the programme.
Outcomes: Primary outcome is overall wellbeing and health (QWB) at 3 months. Secondary outcomes include self-reported cognitive problems, HRQoL, life satisfaction, symptoms of depression and anxiety, post-traumatic stress, fatigue, and sleep disturbances. A process evaluation will evaluate social selection bias, adherence and participants experiences.
Discussion: The CARDIS trial will investigate the use of more accessible and standardised follow-up pathways by complementing existing care structures, thereby enhancing equity in long-term recovery and quality-of-life without requiring additional healthcare resources. The process evaluation will provide data on adherence, social selection, and engagement, essential for future implementation.
Trial registration: The trial is registered at clinicaltrials.gov (NCT07240714).
(Less)- Abstract (Swedish)
- Background: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported outcome measures of a co-created, web-based support programme designed to improve wellbeing, self management, and reintegration into everyday life for cardiac arrest survivors.
Methods: CARDIS is a multicentre, parallel-group, randomised controlled trial enrolling cardiac arrest survivors aged >18 years. Participants will be randomised... (More) - Background: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported outcome measures of a co-created, web-based support programme designed to improve wellbeing, self management, and reintegration into everyday life for cardiac arrest survivors.
Methods: CARDIS is a multicentre, parallel-group, randomised controlled trial enrolling cardiac arrest survivors aged >18 years. Participants will be randomised 1:1 to intervention or control. Both groups will receive standard post-cardiac arrest care, including a routine followup visit with screening and management of cognitive, physical and emotional health, as well as a printed booklet. The intervention group will additionally receive access to a webbased selfguided support programme for 3 months. After study completion, control participants will be offered the programme.
Outcomes: Primary outcome is overall wellbeing and health (QWB) at 3 months. Secondary outcomes include self-reported cognitive problems, HRQoL, life satisfaction, symptoms of depression and anxiety, post-traumatic stress, fatigue, and sleep disturbances. A process evaluation will evaluate social selection bias, adherence and participants experiences.
Discussion: The CARDIS trial will investigate the use of more accessible and standardised follow-up pathways by complementing existing care structures, thereby enhancing equity in long-term recovery and quality-of-life without requiring additional healthcare resources. The process evaluation will provide data on adherence, social selection, and engagement, essential for future implementation.
Trial registration: The trial is registered at clinicaltrials.gov (NCT07240714). (Less)
- author
- Waldemar, Annette
; Israelsson, Johan
; Heimburg, Katarina
LU
; Blennow Nordström, Erik
LU
; Nordberg, Per
; Bremer, Anders
; Årestedt, Kristofer
and Thylén, Ingela
- organization
- publishing date
- 2026-03
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Resuscitation Plus
- volume
- 28
- article number
- 101235
- pages
- 1 - 11
- publisher
- Elsevier
- external identifiers
-
- scopus:105029053838
- ISSN
- 2666-5204
- DOI
- 10.1016/j.resplu.2026.101235
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2026 The Author(s).
- id
- 7e7ff0ff-6012-4282-be22-c9382219e39f
- date added to LUP
- 2026-02-13 09:26:58
- date last changed
- 2026-02-13 10:10:02
@article{7e7ff0ff-6012-4282-be22-c9382219e39f,
abstract = {{<p>Background: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported outcome measures of a co-created, web-based support programme designed to improve wellbeing, self management, and reintegration into everyday life for cardiac arrest survivors.</p><p>Methods: CARDIS is a multicentre, parallel-group, randomised controlled trial enrolling cardiac arrest survivors aged >18 years. Participants will be randomised 1:1 to intervention or control. Both groups will receive standard post-cardiac arrest care, including a routine followup visit with screening and management of cognitive, physical and emotional health, as well as a printed booklet. The intervention group will additionally receive access to a webbased selfguided support programme for 3 months. After study completion, control participants will be offered the programme.</p><p>Outcomes: Primary outcome is overall wellbeing and health (QWB) at 3 months. Secondary outcomes include self-reported cognitive problems, HRQoL, life satisfaction, symptoms of depression and anxiety, post-traumatic stress, fatigue, and sleep disturbances. A process evaluation will evaluate social selection bias, adherence and participants experiences.</p><p>Discussion: The CARDIS trial will investigate the use of more accessible and standardised follow-up pathways by complementing existing care structures, thereby enhancing equity in long-term recovery and quality-of-life without requiring additional healthcare resources. The process evaluation will provide data on adherence, social selection, and engagement, essential for future implementation.</p><p>Trial registration: The trial is registered at clinicaltrials.gov (NCT07240714).</p>}},
author = {{Waldemar, Annette and Israelsson, Johan and Heimburg, Katarina and Blennow Nordström, Erik and Nordberg, Per and Bremer, Anders and Årestedt, Kristofer and Thylén, Ingela}},
issn = {{2666-5204}},
language = {{eng}},
pages = {{1--11}},
publisher = {{Elsevier}},
series = {{Resuscitation Plus}},
title = {{CARDIS (Cardiac ARrest DIgital Support) : study protocol for a randomised controlled trial of a web-based support intervention for cardiac arrest survivors}},
url = {{http://dx.doi.org/10.1016/j.resplu.2026.101235}},
doi = {{10.1016/j.resplu.2026.101235}},
volume = {{28}},
year = {{2026}},
}