Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Bioadhesive Lipid Compositions: Self-Assembly Structures, Functionality, and Medical Applications.

Barauskas, Justas ; Christerson, Lars ; Wadsäter, Maria LU ; Lindström, Fredrick ; Lindqvist, Anna-Karin and Tiberg, Fredrik LU (2014) In Molecular Pharmaceutics 11(3). p.895-903
Abstract
Lipid-based liquid crystalline compositions of phospholipids and diglycerides have unique bioadhesive properties with several medical applications, as exemplified by a lipid-based medical device indicated for management and relief of intraoral pain. The present paper describes the relation between self-assembly properties of phosphatidyl choline (PC) and glycerol dioleate (GDO) mixtures in the presence of aqueous fluids and functional attributes of the system, including: film formation and bioadhesion, intraoral coverage, acceptance by patients, and potential as a drug delivery system. The phase behavior of PC/GDO was characterized using synchrotron small-angle X-ray scattering. Functional properties, including the presence of study... (More)
Lipid-based liquid crystalline compositions of phospholipids and diglycerides have unique bioadhesive properties with several medical applications, as exemplified by a lipid-based medical device indicated for management and relief of intraoral pain. The present paper describes the relation between self-assembly properties of phosphatidyl choline (PC) and glycerol dioleate (GDO) mixtures in the presence of aqueous fluids and functional attributes of the system, including: film formation and bioadhesion, intraoral coverage, acceptance by patients, and potential as a drug delivery system. The phase behavior of PC/GDO was characterized using synchrotron small-angle X-ray scattering. Functional properties, including the presence of study formulations at intraoral surfaces, ease of attachment, taste, and degree of and intraoral pain, were assessed in a crossover clinical pilot study in head and neck cancer patients. An optimum in functional properties was indicated for formulations with a PC/GDO weight ratio of about 35/65, where the lipids form a reversed cubic liquid crystalline micellar phase structure (Fd3m space group) over the relevant temperature range (25-40 °C). (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Pharmaceutics
volume
11
issue
3
pages
895 - 903
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000332348600023
  • pmid:24422996
  • scopus:84901743911
  • pmid:24422996
ISSN
1543-8392
DOI
10.1021/mp400552u
language
English
LU publication?
yes
id
7eb3cd1c-c8f1-4559-854a-f2e7246d5452 (old id 4291466)
date added to LUP
2016-04-01 10:38:25
date last changed
2022-04-27 23:59:59
@article{7eb3cd1c-c8f1-4559-854a-f2e7246d5452,
  abstract     = {{Lipid-based liquid crystalline compositions of phospholipids and diglycerides have unique bioadhesive properties with several medical applications, as exemplified by a lipid-based medical device indicated for management and relief of intraoral pain. The present paper describes the relation between self-assembly properties of phosphatidyl choline (PC) and glycerol dioleate (GDO) mixtures in the presence of aqueous fluids and functional attributes of the system, including: film formation and bioadhesion, intraoral coverage, acceptance by patients, and potential as a drug delivery system. The phase behavior of PC/GDO was characterized using synchrotron small-angle X-ray scattering. Functional properties, including the presence of study formulations at intraoral surfaces, ease of attachment, taste, and degree of and intraoral pain, were assessed in a crossover clinical pilot study in head and neck cancer patients. An optimum in functional properties was indicated for formulations with a PC/GDO weight ratio of about 35/65, where the lipids form a reversed cubic liquid crystalline micellar phase structure (Fd3m space group) over the relevant temperature range (25-40 °C).}},
  author       = {{Barauskas, Justas and Christerson, Lars and Wadsäter, Maria and Lindström, Fredrick and Lindqvist, Anna-Karin and Tiberg, Fredrik}},
  issn         = {{1543-8392}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{895--903}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Molecular Pharmaceutics}},
  title        = {{Bioadhesive Lipid Compositions: Self-Assembly Structures, Functionality, and Medical Applications.}},
  url          = {{http://dx.doi.org/10.1021/mp400552u}},
  doi          = {{10.1021/mp400552u}},
  volume       = {{11}},
  year         = {{2014}},
}