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Ag−Polymer nanocomposites for capture, detection, and destruction of bacteria

Gong, Haiyue LU ; Zhang, Ka LU ; Dicko, Cedric LU orcid ; Buelow, Leif LU and Ye, Lei LU orcid (2019) In ACS Applied Nano Materials 2. p.1655-1663
Abstract
Bacterial infection is one of the major problems for human health. To prevent outbreak of bacteria-caused diseases, early diagnosis of bacterial pathogen and effective destruction of pathogenic microorganisms are in urgent need. In this work, we developed a new multifunctional nanocomposite material that can effectively capture and destroy bacteria. Epoxide-modified nanoparticles were synthesized by microemulsion polymerization and precipitation polymerization. The epoxide groups on the particle surface were reacted with polyethylenimine to introduce cationic amine groups. The amine groups on the nanoparticle surface enhanced the colloidal stability of the particles’ suspension and provided multivalent interactions to bind and destroy the... (More)
Bacterial infection is one of the major problems for human health. To prevent outbreak of bacteria-caused diseases, early diagnosis of bacterial pathogen and effective destruction of pathogenic microorganisms are in urgent need. In this work, we developed a new multifunctional nanocomposite material that can effectively capture and destroy bacteria. Epoxide-modified nanoparticles were synthesized by microemulsion polymerization and precipitation polymerization. The epoxide groups on the particle surface were reacted with polyethylenimine to introduce cationic amine groups. The amine groups on the nanoparticle surface enhanced the colloidal stability of the particles’ suspension and provided multivalent interactions to bind and destroy the bacteria. After further modification with Ag nanoparticles, the final composite nanomaterial was able to not only capture and destroy Gram-negative bacteria but also allow the bacteria’s fingerprint spectra to be obtained through surface-enhanced Raman scattering.
The multifunctional nanoparticles developed in this work offer a new approach toward fast capture, detection, and destruction of pathogenic bacteria. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Raman enhancement, Ag nanoparticles, nanocomposites, antibacterial, polymer nanoparticles, polyethylenimine
in
ACS Applied Nano Materials
volume
2
pages
1655 - 1663
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85077445559
ISSN
2574-0970
DOI
10.1021/acsanm.9b00112
language
English
LU publication?
yes
id
7eb758a4-aefb-4e84-bde8-db03f1438cee
date added to LUP
2019-05-06 11:11:07
date last changed
2022-04-25 23:01:56
@article{7eb758a4-aefb-4e84-bde8-db03f1438cee,
  abstract     = {{Bacterial infection is one of the major problems for human health. To prevent outbreak of bacteria-caused diseases, early diagnosis of bacterial pathogen and effective destruction of pathogenic microorganisms are in urgent need. In this work, we developed a new multifunctional nanocomposite material that can effectively capture and destroy bacteria. Epoxide-modified nanoparticles were synthesized by microemulsion polymerization and precipitation polymerization. The epoxide groups on the particle surface were reacted with polyethylenimine to introduce cationic amine groups. The amine groups on the nanoparticle surface enhanced the colloidal stability of the particles’ suspension and provided multivalent interactions to bind and destroy the bacteria. After further modification with Ag nanoparticles, the final composite nanomaterial was able to not only capture and destroy Gram-negative bacteria but also allow the bacteria’s fingerprint spectra to be obtained through surface-enhanced Raman scattering.<br/>The multifunctional nanoparticles developed in this work offer a new approach toward fast capture, detection, and destruction of pathogenic bacteria.}},
  author       = {{Gong, Haiyue and Zhang, Ka and Dicko, Cedric and Buelow, Leif and Ye, Lei}},
  issn         = {{2574-0970}},
  keywords     = {{Raman enhancement, Ag nanoparticles, nanocomposites, antibacterial, polymer nanoparticles, polyethylenimine}},
  language     = {{eng}},
  pages        = {{1655--1663}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{ACS Applied Nano Materials}},
  title        = {{Ag−Polymer nanocomposites for capture, detection, and destruction of bacteria}},
  url          = {{https://lup.lub.lu.se/search/files/63823288/2019_Ag_polymer_nanocomposites_ACS_Appl_Nano_Mater.pdf}},
  doi          = {{10.1021/acsanm.9b00112}},
  volume       = {{2}},
  year         = {{2019}},
}