RNA in cancer
(2020) p.251-274- Abstract
RNA based processes are in the limelight due to the current technological advances from the fields of high throughput sequencing, structural probing and super-high resolution imaging. RNA biology is implicated in wide range of processes including embryonal development, maintenance of tissue homeostasis or tumor development and progression. We now gain insights at the unprecedented level on how RNAs are modified epitranscriptionally, what are elements regulating translation, how they are dynamically folded, processed to shorter fragments or spliced to elicit tumorigenic effects. Herein, we discuss the implications of the regulation of different RNA species including messenger, non-coding, transfer and ribosomal RNAs and their downstream... (More)
RNA based processes are in the limelight due to the current technological advances from the fields of high throughput sequencing, structural probing and super-high resolution imaging. RNA biology is implicated in wide range of processes including embryonal development, maintenance of tissue homeostasis or tumor development and progression. We now gain insights at the unprecedented level on how RNAs are modified epitranscriptionally, what are elements regulating translation, how they are dynamically folded, processed to shorter fragments or spliced to elicit tumorigenic effects. Herein, we discuss the implications of the regulation of different RNA species including messenger, non-coding, transfer and ribosomal RNAs and their downstream effector pathways for regulation of cancerogenesis.
(Less)
- author
- Cieśla, Maciej LU
- organization
- publishing date
- 2020-01-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Epitranscriptomics, Long non-coding RNAs, RNA in cancer, RNA modifications, Splicing, TRNA-derived fragments
- host publication
- RNA-Based Regulation in Human Health and Disease
- pages
- 24 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85147599997
- ISBN
- 9780128171936
- DOI
- 10.1016/B978-0-12-817193-6.00011-X
- language
- English
- LU publication?
- yes
- id
- 7ee306bd-cdcd-469f-b213-a8257a162c96
- date added to LUP
- 2023-02-20 15:34:13
- date last changed
- 2024-09-17 11:07:38
@inbook{7ee306bd-cdcd-469f-b213-a8257a162c96, abstract = {{<p>RNA based processes are in the limelight due to the current technological advances from the fields of high throughput sequencing, structural probing and super-high resolution imaging. RNA biology is implicated in wide range of processes including embryonal development, maintenance of tissue homeostasis or tumor development and progression. We now gain insights at the unprecedented level on how RNAs are modified epitranscriptionally, what are elements regulating translation, how they are dynamically folded, processed to shorter fragments or spliced to elicit tumorigenic effects. Herein, we discuss the implications of the regulation of different RNA species including messenger, non-coding, transfer and ribosomal RNAs and their downstream effector pathways for regulation of cancerogenesis.</p>}}, author = {{Cieśla, Maciej}}, booktitle = {{RNA-Based Regulation in Human Health and Disease}}, isbn = {{9780128171936}}, keywords = {{Epitranscriptomics; Long non-coding RNAs; RNA in cancer; RNA modifications; Splicing; TRNA-derived fragments}}, language = {{eng}}, month = {{01}}, pages = {{251--274}}, publisher = {{Elsevier}}, title = {{RNA in cancer}}, url = {{http://dx.doi.org/10.1016/B978-0-12-817193-6.00011-X}}, doi = {{10.1016/B978-0-12-817193-6.00011-X}}, year = {{2020}}, }