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RNA in cancer

Cieśla, Maciej LU (2020) p.251-274
Abstract

RNA based processes are in the limelight due to the current technological advances from the fields of high throughput sequencing, structural probing and super-high resolution imaging. RNA biology is implicated in wide range of processes including embryonal development, maintenance of tissue homeostasis or tumor development and progression. We now gain insights at the unprecedented level on how RNAs are modified epitranscriptionally, what are elements regulating translation, how they are dynamically folded, processed to shorter fragments or spliced to elicit tumorigenic effects. Herein, we discuss the implications of the regulation of different RNA species including messenger, non-coding, transfer and ribosomal RNAs and their downstream... (More)

RNA based processes are in the limelight due to the current technological advances from the fields of high throughput sequencing, structural probing and super-high resolution imaging. RNA biology is implicated in wide range of processes including embryonal development, maintenance of tissue homeostasis or tumor development and progression. We now gain insights at the unprecedented level on how RNAs are modified epitranscriptionally, what are elements regulating translation, how they are dynamically folded, processed to shorter fragments or spliced to elicit tumorigenic effects. Herein, we discuss the implications of the regulation of different RNA species including messenger, non-coding, transfer and ribosomal RNAs and their downstream effector pathways for regulation of cancerogenesis.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Epitranscriptomics, Long non-coding RNAs, RNA in cancer, RNA modifications, Splicing, TRNA-derived fragments
host publication
RNA-Based Regulation in Human Health and Disease
pages
24 pages
publisher
Elsevier
external identifiers
  • scopus:85147599997
ISBN
9780128171936
DOI
10.1016/B978-0-12-817193-6.00011-X
language
English
LU publication?
yes
id
7ee306bd-cdcd-469f-b213-a8257a162c96
date added to LUP
2023-02-20 15:34:13
date last changed
2024-09-17 11:07:38
@inbook{7ee306bd-cdcd-469f-b213-a8257a162c96,
  abstract     = {{<p>RNA based processes are in the limelight due to the current technological advances from the fields of high throughput sequencing, structural probing and super-high resolution imaging. RNA biology is implicated in wide range of processes including embryonal development, maintenance of tissue homeostasis or tumor development and progression. We now gain insights at the unprecedented level on how RNAs are modified epitranscriptionally, what are elements regulating translation, how they are dynamically folded, processed to shorter fragments or spliced to elicit tumorigenic effects. Herein, we discuss the implications of the regulation of different RNA species including messenger, non-coding, transfer and ribosomal RNAs and their downstream effector pathways for regulation of cancerogenesis.</p>}},
  author       = {{Cieśla, Maciej}},
  booktitle    = {{RNA-Based Regulation in Human Health and Disease}},
  isbn         = {{9780128171936}},
  keywords     = {{Epitranscriptomics; Long non-coding RNAs; RNA in cancer; RNA modifications; Splicing; TRNA-derived fragments}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{251--274}},
  publisher    = {{Elsevier}},
  title        = {{RNA in cancer}},
  url          = {{http://dx.doi.org/10.1016/B978-0-12-817193-6.00011-X}},
  doi          = {{10.1016/B978-0-12-817193-6.00011-X}},
  year         = {{2020}},
}