Impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis : a systematic review and meta-analysis of randomized controlled trials
Bricca, Alessio ; Struglics, André LU ; Larsson, Staffan LU
; Steultjens, Martijn
; Juhl, Carsten B
and Roos, Ewa M
LU
(2019)
In Arthritis care and research : the official journal of the Arthritis Health Professions Association
71(11).
p.1504-1515
- Abstract
OBJECTIVE: To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).
METHODS: Literature search up to September 2017 in five major databases with no restriction on publication year or language. Data were extracted from the first available follow-up time point and we performed a narrative synthesis for the effect of exercise therapy on molecular biomarkers related to cartilage and inflammation. A subset of studies reporting sufficient data was combined in a meta-analysis, using an adjusted random effects model.
RESULTS: Twelve RCTs, involving... (More)
OBJECTIVE: To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).
METHODS: Literature search up to September 2017 in five major databases with no restriction on publication year or language. Data were extracted from the first available follow-up time point and we performed a narrative synthesis for the effect of exercise therapy on molecular biomarkers related to cartilage and inflammation. A subset of studies reporting sufficient data was combined in a meta-analysis, using an adjusted random effects model.
RESULTS: Twelve RCTs, involving 57 study comparisons at 4 to 24 weeks following an exercise therapy intervention were included. Exercise therapy decreased molecular biomarkers in 17 (30%) study comparisons, had no effect in 36 (63%), and increased molecular biomarkers in four (7%) study comparisons. Meta-analyses of nine biomarkers showed that exercise therapy was associated with non-significant reductions of C-reactive protein, C-terminal crosslinking telopeptide of type II collagen, tumor necrosis factor alpha (TNF-α), soluble TNF-α receptor-1 and -2, C2C neoepitope of type II collagen and cartilage oligomeric matrix protein compared to non-exercising control groups and had no effect on interleukin-6 and soluble interleukin 6 receptor.
CONCLUSIONS: Exercise therapy is not harmful, as it does not increase the concentration of molecular biomarkers related to cartilage turnover and inflammation, implicated in osteoarthritis progression. The overall quality of evidence was downgraded to low because of the limited number of RCTs available. This article is protected by copyright. All rights reserved.
(Less)
- author
- Bricca, Alessio
; Struglics, André
LU
; Larsson, Staffan
LU
; Steultjens, Martijn
; Juhl, Carsten B
and Roos, Ewa M
LU
- organization
- publishing date
- 2019-11
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arthritis care and research : the official journal of the Arthritis Health Professions Association
- volume
- 71
- issue
- 11
- pages
- 12 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:30320965
- scopus:85065979152
- ISSN
- 2151-4658
- DOI
- 10.1002/acr.23786
- language
- English
- LU publication?
- yes
- id
- 7eebf9f3-9ed1-4812-b688-50f34abe7869
- date added to LUP
- 2019-01-31 14:17:43
- date last changed
- 2024-03-18 23:48:23
@article{7eebf9f3-9ed1-4812-b688-50f34abe7869,
abstract = {{<p>OBJECTIVE: To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).</p><p>METHODS: Literature search up to September 2017 in five major databases with no restriction on publication year or language. Data were extracted from the first available follow-up time point and we performed a narrative synthesis for the effect of exercise therapy on molecular biomarkers related to cartilage and inflammation. A subset of studies reporting sufficient data was combined in a meta-analysis, using an adjusted random effects model.</p><p>RESULTS: Twelve RCTs, involving 57 study comparisons at 4 to 24 weeks following an exercise therapy intervention were included. Exercise therapy decreased molecular biomarkers in 17 (30%) study comparisons, had no effect in 36 (63%), and increased molecular biomarkers in four (7%) study comparisons. Meta-analyses of nine biomarkers showed that exercise therapy was associated with non-significant reductions of C-reactive protein, C-terminal crosslinking telopeptide of type II collagen, tumor necrosis factor alpha (TNF-α), soluble TNF-α receptor-1 and -2, C2C neoepitope of type II collagen and cartilage oligomeric matrix protein compared to non-exercising control groups and had no effect on interleukin-6 and soluble interleukin 6 receptor.</p><p>CONCLUSIONS: Exercise therapy is not harmful, as it does not increase the concentration of molecular biomarkers related to cartilage turnover and inflammation, implicated in osteoarthritis progression. The overall quality of evidence was downgraded to low because of the limited number of RCTs available. This article is protected by copyright. All rights reserved.</p>}},
author = {{Bricca, Alessio and Struglics, André and Larsson, Staffan and Steultjens, Martijn and Juhl, Carsten B and Roos, Ewa M}},
issn = {{2151-4658}},
language = {{eng}},
number = {{11}},
pages = {{1504--1515}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Arthritis care and research : the official journal of the Arthritis Health Professions Association}},
title = {{Impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis : a systematic review and meta-analysis of randomized controlled trials}},
url = {{http://dx.doi.org/10.1002/acr.23786}},
doi = {{10.1002/acr.23786}},
volume = {{71}},
year = {{2019}},
}