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Targeting Integrin α4β7 in Steroid-Refractory Intestinal Graft-versus-Host Disease

Fløisand, Yngvar; Lundin, Knut E A; Lazarevic, Vladimir LU ; Kristiansen, Jørn Dehli; Osnes, Liv T N; Tjønnfjord, Geir E.; Reims, Henrik Mikael and Gedde-Dahl, Tobias (2017) In Biology of Blood and Marrow Transplantation 23(1). p.172-175
Abstract

Steroid refractory acute graft-versus-host-disease of the gut is a serious complication associated with high mortality after allogeneic stem cell transplantation. Treatment options are limited and not predictably effective. We describe the treatment of steroid-refractory acute graft-versus-host-disease with vedolizumab, an antibody directed against integrin α4β7, in 6 patients. All patients responded, and 4 of 6 patients are alive with a median follow-up of 10 months.

Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Graft-versus-host disease, Gut GVHD, Integrin, Stem cell transplant, Steroid refractory, Vedolizumab
in
Biology of Blood and Marrow Transplantation
volume
23
issue
1
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:85006351875
ISSN
1083-8791
DOI
10.1016/j.bbmt.2016.10.009
language
English
LU publication?
no
id
7f11bab7-3356-4615-82e4-48cb033ebcc8
date added to LUP
2017-01-16 09:57:02
date last changed
2018-01-07 11:45:10
@article{7f11bab7-3356-4615-82e4-48cb033ebcc8,
  abstract     = {<p>Steroid refractory acute graft-versus-host-disease of the gut is a serious complication associated with high mortality after allogeneic stem cell transplantation. Treatment options are limited and not predictably effective. We describe the treatment of steroid-refractory acute graft-versus-host-disease with vedolizumab, an antibody directed against integrin α4β7, in 6 patients. All patients responded, and 4 of 6 patients are alive with a median follow-up of 10 months.</p>},
  author       = {Fløisand, Yngvar and Lundin, Knut E A and Lazarevic, Vladimir and Kristiansen, Jørn Dehli and Osnes, Liv T N and Tjønnfjord, Geir E. and Reims, Henrik Mikael and Gedde-Dahl, Tobias},
  issn         = {1083-8791},
  keyword      = {Graft-versus-host disease,Gut GVHD,Integrin,Stem cell transplant,Steroid refractory,Vedolizumab},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {172--175},
  publisher    = {Elsevier},
  series       = {Biology of Blood and Marrow Transplantation},
  title        = {Targeting Integrin α4β7 in Steroid-Refractory Intestinal Graft-versus-Host Disease},
  url          = {http://dx.doi.org/10.1016/j.bbmt.2016.10.009},
  volume       = {23},
  year         = {2017},
}