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Targeting Integrin α4β7 in Steroid-Refractory Intestinal Graft-versus-Host Disease

Fløisand, Yngvar ; Lundin, Knut E A ; Lazarevic, Vladimir LU ; Kristiansen, Jørn Dehli ; Osnes, Liv T N ; Tjønnfjord, Geir E. ; Reims, Henrik Mikael and Gedde-Dahl, Tobias (2017) In Biology of Blood and Marrow Transplantation 23(1). p.172-175
Abstract

Steroid refractory acute graft-versus-host-disease of the gut is a serious complication associated with high mortality after allogeneic stem cell transplantation. Treatment options are limited and not predictably effective. We describe the treatment of steroid-refractory acute graft-versus-host-disease with vedolizumab, an antibody directed against integrin α4β7, in 6 patients. All patients responded, and 4 of 6 patients are alive with a median follow-up of 10 months.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Graft-versus-host disease, Gut GVHD, Integrin, Stem cell transplant, Steroid refractory, Vedolizumab
in
Biology of Blood and Marrow Transplantation
volume
23
issue
1
pages
4 pages
publisher
Elsevier
external identifiers
  • pmid:27777142
  • scopus:85006351875
ISSN
1083-8791
DOI
10.1016/j.bbmt.2016.10.009
language
English
LU publication?
no
id
7f11bab7-3356-4615-82e4-48cb033ebcc8
date added to LUP
2017-01-16 09:57:02
date last changed
2024-04-05 14:29:01
@article{7f11bab7-3356-4615-82e4-48cb033ebcc8,
  abstract     = {{<p>Steroid refractory acute graft-versus-host-disease of the gut is a serious complication associated with high mortality after allogeneic stem cell transplantation. Treatment options are limited and not predictably effective. We describe the treatment of steroid-refractory acute graft-versus-host-disease with vedolizumab, an antibody directed against integrin α4β7, in 6 patients. All patients responded, and 4 of 6 patients are alive with a median follow-up of 10 months.</p>}},
  author       = {{Fløisand, Yngvar and Lundin, Knut E A and Lazarevic, Vladimir and Kristiansen, Jørn Dehli and Osnes, Liv T N and Tjønnfjord, Geir E. and Reims, Henrik Mikael and Gedde-Dahl, Tobias}},
  issn         = {{1083-8791}},
  keywords     = {{Graft-versus-host disease; Gut GVHD; Integrin; Stem cell transplant; Steroid refractory; Vedolizumab}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{172--175}},
  publisher    = {{Elsevier}},
  series       = {{Biology of Blood and Marrow Transplantation}},
  title        = {{Targeting Integrin α4β7 in Steroid-Refractory Intestinal Graft-versus-Host Disease}},
  url          = {{http://dx.doi.org/10.1016/j.bbmt.2016.10.009}},
  doi          = {{10.1016/j.bbmt.2016.10.009}},
  volume       = {{23}},
  year         = {{2017}},
}