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TRPV1 har viktig roll i hjärnan

Zygmunt, Peter LU orcid (2021) In Lakartidningen 118.
Abstract

The discovery of TRPV1 as a receptor for capsaicin, the pungent ingredient in chili pepper, and noxious heat has triggered immense research on the role of TRP channels as polymodal receptors in sensory neuronal signaling. The rich abundance of TRPV1 in nociceptive primary afferents and its involvement in inflammatory and neuropathic pain encouraged the development of analgesics acting on TRPV1. However, the development of TRPV1 antagonists has been hampered by hyperthermia and insensitivity to noxious hot temperatures. Notably, the involvement of TRPV1 and endovanilloids in CNS signaling has opened up the possibility to develop TRPV1 drug therapies for treatment of pain alongside various CNS diseases and mental health conditions.

Please use this url to cite or link to this publication:
author
organization
alternative title
Involvement of TRPV1 in CNS signaling has opened up the possibility to develop TRPV1 drug therapies
publishing date
type
Contribution to journal
publication status
published
subject
in
Lakartidningen
volume
118
publisher
Swedish Medical Association
external identifiers
  • scopus:85122550122
  • pmid:34894399
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
7f18b662-2053-4738-a4f6-fd959e6f609c
date added to LUP
2022-03-10 12:50:18
date last changed
2024-05-30 10:38:52
@article{7f18b662-2053-4738-a4f6-fd959e6f609c,
  abstract     = {{<p>The discovery of TRPV1 as a receptor for capsaicin, the pungent ingredient in chili pepper, and noxious heat has triggered immense research on the role of TRP channels as polymodal receptors in sensory neuronal signaling. The rich abundance of TRPV1 in nociceptive primary afferents and its involvement in inflammatory and neuropathic pain encouraged the development of analgesics acting on TRPV1. However, the development of TRPV1 antagonists has been hampered by hyperthermia and insensitivity to noxious hot temperatures. Notably, the involvement of TRPV1 and endovanilloids in CNS signaling has opened up the possibility to develop TRPV1 drug therapies for treatment of pain alongside various CNS diseases and mental health conditions.</p>}},
  author       = {{Zygmunt, Peter}},
  issn         = {{0023-7205}},
  language     = {{swe}},
  month        = {{12}},
  publisher    = {{Swedish Medical Association}},
  series       = {{Lakartidningen}},
  title        = {{TRPV1 har viktig roll i hjärnan}},
  volume       = {{118}},
  year         = {{2021}},
}